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The FASEB Journal, Vol 2, 2791-2796, Copyright © 1988 by The Federation of American Societies for Experimental Biology

REVIEWS

Resistance of multidrug-resistant lines to natural killer-like cell- mediated cytotoxicity

G Woods, LA Lund, M Naik, V Ling and A Ochi
Department of Immunology, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada.

Multidrug resistance (MDR) refers to a complex phenotype that describes a number of features characterized primarily by resistance to a wide range of structurally unrelated drugs. In this paper we investigated the relationship between drug resistance and resistance to NK-mediated cytotoxicity. Studies with two independently selected multidrug- resistant cell lines indicated that increased drug resistance was associated with both an increased resistance to NK-mediated cytotoxicity and increased levels of membrane P-glycoprotein expression. This resistance to cytotoxicity appears to result partly from an alteration in the membrane structure of the target cells inasmuch as there was a reduction in effector:target cell recognition. Resistance to NK-mediated cytotoxicity should be included with the numerous pleiotropic changes associated with the multidrug resistance phenotype.


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Copyright © 1988 by The Federation of American Societies for Experimental Biology.