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The FASEB Journal, Vol 2, 2722-2725, Copyright © 1988 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Glucocorticoids in muscular dystrophy: beneficial effects of dexamethasone on avian myopathy

RK Entrikin, RT Abresch, DP Bradford, DB Larson, KJ Longley and BW Wilson
Department of Physical Medicine and Rehabilitation, School of Medicine, University of California, Davis 95616.

A corticosteroid with mixed glucocorticoid-mineralocorticoid actions was previously shown to improve neuromuscular function in muscular dystrophic chickens. The significance of that finding was recently underscored by reports that a mixed-action corticosteroid improved muscle function in Duchenne dystrophy patients, albeit at high doses. In the present study a pure glucocorticoid improved function and retarded muscle histopathology in the chicken, but a pure mineralocorticoid did not. These observations suggest that elucidation of mechanisms by which glucocorticoids beneficially affect dystrophic muscle could lead to development of more effective therapies.




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Copyright © 1988 by The Federation of American Societies for Experimental Biology.