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The FASEB Journal, Vol 2, 2584-2590, Copyright © 1988 by The Federation of American Societies for Experimental Biology

REVIEWS

T cell adhesion molecules

BE Bierer and SJ Burakoff
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

Cell adhesion or conjugate formation between T lymphocytes and other cells is an important early step in the generation of the immune response. Although the antigen-specific T cell receptor confers antigen recognition and specificity, a number of other molecules expressed on the T cell surface are involved in the regulation of lymphocyte adhesion. T cell molecules that function to strengthen adhesion include lymphocyte function-associated antigen (LFA)-1, CD2, CD4, and CD8. Their ligands have recently been identified. LFA-1 is a member of the integrin family of adhesion receptors and one of its ligands is intercellular adhesion molecule-1 (ICAM-1); a ligand for CD2 is LFA-3; and ligands for CD4 and CD8 appear to be major histocompatibility complex class II and class I molecules, respectively. In addition, T cells express a number of receptors thought to be involved in cell matrix adhesion. The function and significance of these T cell adhesion receptors and their ligands are reviewed.


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P Lenert, D Kroon, H Spiegelberg, E. Golub, and M Zanetti
Human CD4 binds immunoglobulins
Science, June 29, 1990; 248(4963): 1639 - 1643.
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Copyright © 1988 by The Federation of American Societies for Experimental Biology.