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The FASEB Journal, Vol 2, 2569-2574, Copyright © 1988 by The Federation of American Societies for Experimental Biology

REVIEWS

Evidence for involvement of guanine nucleotide-binding regulatory proteins in the activation of phospholipases by hormones

JN Fain, MA Wallace and RJ Wojcikiewicz
Department of Biochemistry, College of Medicine, University of Tennesse, Memphis 38163.

Guanine nucleotide-binding regulatory proteins similar to Gs and Gi may be involved in the activation of phospholipases C and A2 by hormones and other ligands. The binding of hormones to receptors that activate phospholipase C is decreased by guanine nucleotides and these hormones also stimulate a high-affinity GTPase activity in cell membranes. Effects of hormones on phospholipase C activity in cell-free preparations are dependent on the presence of guanine nucleotides. In addition, fluoride and nonhydrolyzable GTP analogs activate phospholipases in a manner that can be blocked by GDP beta S. The putative guanine nucleotide-binding regulatory protein that appears to be involved in activation of phospholipase C is sensitive to pertussis toxin in some cells but not in others.


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Copyright © 1988 by The Federation of American Societies for Experimental Biology.