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The FASEB Journal, Vol 2, 48-51, Copyright © 1988 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Substance P and astrocytes: stimulation of the cyclooxygenase pathway of arachidonic acid metabolism

HP Hartung, K Heininger, B Schafer and KV Toyka
Department of Neurology, University of Dusseldorf, Federal Republic of Germany.

Substance P (SP) may play an important role in the interactions between the nervous system and the immune system. Astrocytes carry receptors for SP on their surfaces. We examined whether ligand-induced receptor activation would lead to the release of arachidonic acid metabolites. SP (10(-10)-10(-8) M) evokes the formation of prostaglandin E and thromboxane B2 in a dose-dependent manner. Structure-activity studies disclosed that the COOH-terminal peptide sequence of SP is primarily responsible for this biological activity. The generation by astrocytes of arachidonate-derived proinflammatory and immunoregulatory compounds in response to SP receptor activation may be relevant to immunoinflammatory responses within the central nervous system and emphasizes the concept of neuroimmunomodulation.


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Copyright © 1988 by The Federation of American Societies for Experimental Biology.