FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weiss, L.
Right arrow Articles by Honn, K. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weiss, L.
Right arrow Articles by Honn, K. V.

The FASEB Journal, Vol 2, 12-21, Copyright © 1988 by The Federation of American Societies for Experimental Biology

REVIEWS

Interactions of cancer cells with the microvasculature during metastasis

L Weiss, FW Orr and KV Honn
Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, New York 14263.

Metastasis of cancer via the bloodstream is a major factor in the diagnosis, treatment, and prognosis of patients with cancer. Key events in hematogenous metastasis occur in the microvasculature. This is a brief, selective review of some interactions involving cancer cells and the microvasculature in pathological sequence, specifically: 1) intravasation of cancer cells; 2) the arrest of circulating cancer in the microvasculature; 3) cancer cell trauma associated with arrest; 4) microvascular trauma; 5) the inflammatory and 6) coagulative responses associated with arrest; and 7) the fate of arrested cancer cells. The evidence shows that in addition to providing routes for cancer cell dissemination and arrest sites for cancer cell emboli, the microvasculature, through a series of complex interactions with cancer cells, controls the efficiency of and acts as a rate regulator for the metastatic process.


This article has been cited by other articles:


Home page
 Cancer Res.Home page
O. Berezovskaya, A. D. Schimmer, A. B. Glinskii, C. Pinilla, R. M. Hoffman, J. C. Reed, and G. V. Glinsky
Increased Expression of Apoptosis Inhibitor Protein XIAP Contributes to Anoikis Resistance of Circulating Human Prostate Cancer Metastasis Precursor Cells
Cancer Res., March 15, 2005; 65(6): 2378 - 2386.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
Y. Refaely, S. Sadetzki, A. Chetrit, D. A. Simansky, M. Paley, B. Modan, and A. Yellin
The sequence of vessel interruption during lobectomy for non-small cell lung cancer: Is it indeed important?
J. Thorac. Cardiovasc. Surg., June 1, 2003; 125(6): 1313 - 1320.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
Y. Kimura
Carp Oil or Oleic Acid, but Not Linoleic Acid or Linolenic Acid, Inhibits Tumor Growth and Metastasis in Lewis Lung Carcinoma-Bearing Mice
J. Nutr., July 1, 2002; 132(7): 2069 - 2075.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. K. L. Woodward, C. E. Nichols, I. G. Rennie, M. A. Parsons, A. K. Murray, and K. Sisley
An In Vitro Assay to Assess Uveal Melanoma Invasion across Endothelial and Basement Membrane Barriers
Invest. Ophthalmol. Vis. Sci., June 1, 2002; 43(6): 1708 - 1714.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Li, M. Tondravi, J. Liu, E. Smith, C. C. Haudenschild, M. Kaczmarek, and X. Zhan
Cortactin Potentiates Bone Metastasis of Breast Cancer Cells
Cancer Res., September 1, 2001; 61(18): 6906 - 6911.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B.-K. Moon, Y. J. Lee, P. Battle, J. M. Jessup, A. Raz, and H.-R. C. Kim
Galectin-3 Protects Human Breast Carcinoma Cells against Nitric Oxide-Induced Apoptosis : Implication of Galectin-3 Function during Metastasis
Am. J. Pathol., September 1, 2001; 159(3): 1055 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
Y. Kimura and H. Okuda
Resveratrol Isolated from Polygonum cuspidatum Root Prevents Tumor Growth and Metastasis to Lung and Tumor-Induced Neovascularization in Lewis Lung Carcinoma-Bearing Mice
J. Nutr., June 1, 2001; 131(6): 1844 - 1849.
[Abstract] [Full Text]

Home page
 GlycobiologyHome page
L. A. Dempsey, T. B. Plummer, S. L. Coombes, and J. L. Platt
Heparanase expression in invasive trophoblasts and acute vascular damage
Glycobiology, May 1, 2000; 10(5): 467 - 475.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Yang, P. Jiang, Z. An, E. Baranov, L. Li, S. Hasegawa, M. Al-Tuwaijri, T. Chishima, H. Shimada, A. R. Moossa, et al.
Genetically Fluorescent Melanoma Bone and Organ Metastasis Models
Clin. Cancer Res., November 1, 1999; 5(11): 3549 - 3559.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. M. Jessup, P. Battle, H. Waller, K. H. Edmiston, D. B. Stolz, S. C. Watkins, J. Locker, and K. Skena
Reactive Nitrogen and Oxygen Radicals Formed during Hepatic Ischemia-Reperfusion Kill Weakly Metastatic Colorectal Cancer Cells
Cancer Res., April 1, 1999; 59(8): 1825 - 1829.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
G. Rice and M. Bevilacqua
An inducible endothelial cell surface glycoprotein mediates melanoma adhesion
Science, December 8, 1989; 246(4935): 1303 - 1306.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
J. Carretero, E. Obrador, J. M. Esteve, A. Ortega, J. A. Pellicer, F. V. Sempere, and J. M. Estrela
Tumoricidal Activity of Endothelial Cells. INHIBITION OF ENDOTHELIAL NITRIC OXIDE PRODUCTION ABROGATES TUMOR CYTOTOXICITY INDUCED BY HEPATIC SINUSOIDAL ENDOTHELIUM IN RESPONSE TO B16 MELANOMA ADHESION IN VITRO
J. Biol. Chem., July 6, 2001; 276(28): 25775 - 25782.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by The Federation of American Societies for Experimental Biology.