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A postulated role for microRNA in cellular differentiation

Rosetta Genomics, 10 Plaut Street, Rehovot 76706, Israel

Correspondence: E-mail: bentwich{at}rosettagenomics.com

Over the past two decades a variety of mechanisms regulating cellular differentiation have been uncovered. These include signaling by morphogens or membrane-associated ligands and asymmetric segregation of cytoplasmic components. Most of these processes are driven by protein coding genes. Here I describe another possible cellular differentiation mechanism that involves asymmetric segregation of microRNAs, a group of recently discovered non-protein coding genes that have been shown to be involved in differentiation.—Bentwich, I. A postulated role for microRNA in cellular differentiation.

Key Words: embryogenesis • UTR • genomic module • protein coding genes • microRNA gene cluster

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