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Dopamine receptors set the pattern of activity generated in subthalamic neurons

J. Baufreton^*,, Z.-T. Zhu, M. Garret^*, B. Bioulac^*, S. W. Johnson and A. I. Taupignon^*,1

^* UMR 5543, University Victor Segalen, Bordeaux, France;
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; and
Departments of Physiology and Pharmacology, and Neurology, Oregon Health and Science University, Portland, Oregon, USA

¹ Correspondence: University Victor Segalen, 146 rue Saignat, Bordeaux, 33076 cedx France. E-mail: anne.taupignon{at}umr5543.u-bordeaux2.fr

Information processing in the brain requires adequate background neuronal activity. As Parkinson’s disease progresses, patients typically become akinetic; the death of dopaminergic neurons leads to a dopamine-depleted state, which disrupts information processing related to movement in a brain area called the basal ganglia. Using agonists of dopamine receptors in the D1 and D2 families on rat brain slices, we show that dopamine receptors in these two families govern the firing pattern of neurons in the subthalamic nucleus, a crucial part of the basal ganglia. We propose a conceptual frame, based on specific properties of dopamine receptors, to account for the dominance of different background firing patterns in normal and dopamine-depleted states.— Baufreton, J., Zhu, Z.-T., Garret. M., Bioulac, B., Johnson, S. W., Taupignon, A. I. Dopamine receptors set the pattern of activity generated in subthalamic neurons.

Key Words: subthalamic nucleus • slow-wave sleep • burst-firing • basal ganglia

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