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Centre for Rheumatology, Department of Medicine, Royal Free & University College Medical School, Rowland Hill Street, London, UK NW3 2PF
1Correspondence: Centre for Rheumatology, Department of Medicine, Royal Free & University College Medical School, Rowland Hill St., London, UK NW3 2PF. E-mail: a.leask{at}rfc.ucl.ac.uk
The cause of fibrotic diseases, pathologies characterized by excessive production, deposition, and contraction of extracellular matrix, is unknown. To understand the molecular basis of fibrotic disease, it is essential to appreciate how matrix deposition is normally controlled and how this process is dysregulated in fibrogenesis. This review discusses the current state of knowledge concerning interactions among the profibrotic proteins transforming growth factor-ß (TGF-ß), connective tissue growth factor (CTGF, CCN2), and ED-A fibronectin (ED-A FN) and the antifibrotic proteins tumor necrosis factor-
(TNF-) and 
-interferon (IFN-).—Leask, A., Abraham, D. J. TGF-ß signaling and the fibrotic response.
Key Words: Smad • MAP kinase • CTGF • prostacyclin • TNF- • scleroderma • ED-A fibronectin
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
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|
|
|
|
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|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 H. Higashiyama, D. Yoshimoto, Y. Okamoto, H. Kikkawa, S. Asano, and M. Kinoshita Receptor-activated Smad localisation in Bleomycin-induced pulmonary fibrosis J. Clin. Pathol., March 1, 2007; 60(3): 283 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 X. Liu, S. Q. Sun, A. Hassid, and R. S. Ostrom cAMP Inhibits Transforming Growth Factor-beta-Stimulated Collagen Synthesis via Inhibition of Extracellular Signal-Regulated Kinase 1/2 and Smad Signaling in Cardiac Fibroblasts Mol. Pharmacol., December 1, 2006; 70(6): 1992 - 2003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 C. Neurohr, S. L. Nishimura, and D. Sheppard Activation of Transforming Growth Factor-beta by the Integrin {alpha}vbeta8 Delays Epithelial Wound Closure Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 252 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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