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(The FASEB Journal. 2002;16:1087-1092.)
© 2002 FASEB

Androgen-dependent expression of Fc{gamma}RIIB2 by thyrocytes from patients with autoimmune Graves’ disease: a possible molecular clue for sex dependence of autoimmune disease

VALÉRIE ESTIENNE*,{dagger}, CHRISTINE DUTHOIT{dagger}, MANUELA REICHERT*, ASJA PRAETOR*,{ddagger}, PIERRE CARAYON{dagger}, WALTER HUNZIKER*,{ddagger}1 and JEAN RUF{dagger}1

* Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland;
{dagger} U555 INSERM, Faculté de Médecine Timone, F-13385 Marseille Cedex 5, France; and
{ddagger} Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore

1Correspondence: U555 INSERM, Faculté de Médecine Timone, 27 Bd Jean Moulin, F-13385 Marseille Cedex 5, France (Jean.Ruf{at}medecine.univ-mrs.fr) and Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Republic of Singapore (Hunziker{at}imcb.nus.edu.sg).

ABSTRACT

Thyrocyte expression of HLA class I and class II antigens and related accessory molecules would convert these epithelial cells into functional antigen-presenting cells. Here we show that whereas normal thyrocytes express FcRn, Graves’ disease thyrocytes also express Fc{gamma}RIIB2. We further find that expression of Fc{gamma}RIIB2, but not FcRn, is repressed by dihydrotestosterone. By mediating the uptake and transport of autoantibodies, we suggest that these IgG Fc receptors contribute in various ways to the onset and/or progression of autoimmune thyroid diseases. The androgen-mediated decrease of Fc{gamma}RIIB2 expression in Graves’ disease thyrocytes also provides a rationale for the predominant susceptibility of women to develop an autoimmune thyroid disease. Our findings open up a new prospect to autoimmunity, linking the role of the target organ to the sex dependence in autoimmune disease.—Estienne, V., Duthoit, C., Reichert, M., Praetor, A., Carayon, P., Hunziker, W., Ruf, J. Androgen-dependent expression of Fc{gamma}RIIB2 by thyrocytes from patients with autoimmune Graves’ disease: a possible molecular clue for sex dependence of autoimmune disease.


Key Words: autoimmune diseases • IgG Fc receptors • sex dependence




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