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(The FASEB Journal. 2002;16:849-856.)
© 2002 FASEB

Regional manifestations and control of the immune system

SOHEYLA SAADI*,{dagger}, LUCILE E. WRENSHALL{ddagger} and JEFFREY L. PLATT*,§1

Departments of
* Surgery,
{dagger} Molecular Biology and Biochemistry, Mayo Clinic, Rochester, Minnesota, USA;
{ddagger} Department of Surgery, University of Washington Seattle, Washington, USA; and
§ Transplantation Biology and Departments of Immunology and Pediatrics, Mayo Clinic, Rochester, Minnesota, USA

1Correspondence: Departments of Surgery and Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA. E-mail: Platt.jeffrey{at}mayo.edu

ABSTRACT

Although immune responses are generally considered to be systemic, local events such as interaction of complement products with blood vessels and with inflammatory cells play a pivotal role in determining the nature and manifestations of immune responses. This paper will discuss how blood vessel physiology and immunity influence one another to reach homeostasis upon exposure to an infectious agent. We review new insights into the mechanisms by which the microenvironment of tissues protects against microbial invasion yet facilitates migration of leukocytes and ‘decides’ whether immunity or tolerance ensues and whether, in the face of immunity, protective responses or tissue injury ensues. These ‘decisions’ are made based on interaction of components of normal tissues such as proteoglycans and injured tissues such as cell-associated cytokines with receptors on immune cells and blood vessels.—Saadi, S., Wrenshall, L. E., Platt, J. L. Regional manifestations and control of the immune system.


Key Words: immunity • vascular endothelium • heparan sulfate proteoglycan • complement • antigen-presenting cells




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