| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Laboratory of Tumor and Development Biology,
*
Laboratory of Connective Tissues Biology, University of Liège, Sart Tilman, B-4000 Liège, Belgium; and
Victorian Breast Cancer Research Consortium Invasion and Metastasis Unit, St Vincent’s Institute of Medical Research, Fitzroy, Australia
1Correspondence: Laboratory of Biology of Tumor and Development, University of Liège, 4000 Sart-Tilman, Liège, Belgium. E-mail: agnes.noel{at}ulg.ac.be
Membrane type 1 metalloprotease (MT1-MMP) is a transmembrane metalloprotease that plays a major role in the extracellular matrix remodeling, directly by degrading several of its components and indirectly by activating pro-MMP2. We investigated the effects of MT1-MMP overexpression on in vitro and in vivo properties of human breast adenocarcinoma MCF7 cells, which do not express MT1-MMP or MMP-2. MT1-MMP and MMP-2 cDNAs were either transfected alone or cotransfected. All clones overexpressing MT1-MMP 1) were able to activate endogenous or exogenous pro-MMP-2, 2) displayed an enhanced in vitro invasiveness through matrigel-coated filters independent of MMP-2 transfection, 3) induced the rapid development of highly vascularized tumors when injected subcutanously in nude mice, and 4) promoted blood vessels sprouting in the rat aortic ring assay. These effects were observed in all clones overexpressing MT1-MMP regardless of MMP-2 expression levels, suggesting that the production of MMP-2 by tumor cells themselves does not play a critical role in these events. The angiogenic phenotype of MT1-MMP-producing cells was associated with an up-regulation of VEGF expression. These results emphasize the importance of MT1-MMP during tumor angiogenesis and open new opportunities for the development of anti-angiogenic strategies combining inhibitors of MT1-MMP and VEGF antagonists.—Sounni, N. E., Devy, L., Hajitou, A., Frankenne, F., Munaut, C., Gilles, C., Deroanne, C., Thompson, E. W., Foidart, J. M., Noel, A. MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression.
Key Words: matrix metalloproteinases • MCF7 cells • MT1-MMP overexpression • VEGF
This article has been cited by other articles:
|
|
 |
|
  F. Bougatef, C. Quemener, S. Kellouche, B. Naimi, M.-P. Podgorniak, G. Millot, E. E. Gabison, F. Calvo, C. Dosquet, C. Lebbe, et al. EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2{alpha}-mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2 Blood, December 24, 2009; 114(27): 5547 - 5556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, M. J. Wilson, J. W. Slaton, A. A. Sinha, S. L. Ewing, and D. Pei Increased Aggressiveness of Human Prostate PC-3 Tumor Cells Expressing Cell Surface Localized Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) J Androl, May 1, 2009; 30(3): 259 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Devy, L. Huang, L. Naa, N. Yanamandra, H. Pieters, N. Frans, E. Chang, Q. Tao, M. Vanhove, A. Lejeune, et al. Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis Cancer Res., February 15, 2009; 69(4): 1517 - 1526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. G. Yu, X. Liu, S. Kiss, E. Connolly, E. S. Gragoudas, N. A. Michaud, O. V. Bulgakov, M. Adamian, M. M. DeAngelis, J. W. Miller, et al. Increased Choroidal Neovascularization following Laser Induction in Mice Lacking Lysyl Oxidase-like 1 Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2599 - 2605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Plaisier, P. Koolwijk, F. Willems, F. M. Helmerhorst, and V. W.M. van Hinsbergh Pericellular-acting proteases in human first trimester decidua Mol. Hum. Reprod., January 1, 2008; 14(1): 41 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mineur, A. C. Colige, Christophe. F. Deroanne, J. Dubail, F. Kesteloot, Y. Habraken, A. Noel, S. Voo, J. Waltenberger, C. M. Lapiere, et al. Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents J. Cell Biol., December 17, 2007; 179(6): 1261 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Hasaneen, S. Zucker, R. Z. Lin, G. G. Vaday, R. A. Panettieri, and H. D. Foda Angiogenesis is induced by airway smooth muscle strain Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L1059 - L1068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Bonfil, Z. Dong, J. C. Trindade Filho, A. Sabbota, P. Osenkowski, S. Nabha, H. Yamamoto, S. R. Chinni, H. Zhao, S. Mobashery, et al. Prostate Cancer-Associated Membrane Type 1-Matrix Metalloproteinase: A Pivotal Role in Bone Response and Intraosseous Tumor Growth Am. J. Pathol., June 1, 2007; 170(6): 2100 - 2111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Taniwaki, H. Fukamachi, K. Komori, Y. Ohtake, T. Nonaka, T. Sakamoto, T. Shiomi, Y. Okada, T. Itoh, S. Itohara, et al. Stroma-Derived Matrix Metalloproteinase (MMP)-2 Promotes Membrane Type 1-MMP-Dependent Tumor Growth in Mice Cancer Res., May 1, 2007; 67(9): 4311 - 4319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Yana, H. Sagara, S. Takaki, K. Takatsu, K. Nakamura, K. Nakao, M. Katsuki, S.-i. Taniguchi, T. Aoki, H. Sato, et al. Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells J. Cell Sci., May 1, 2007; 120(9): 1607 - 1614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Basile, K. Holmbeck, T. H. Bugge, and J. S. Gutkind MT1-MMP Controls Tumor-induced Angiogenesis through the Release of Semaphorin 4D J. Biol. Chem., March 2, 2007; 282(9): 6899 - 6905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takeda, A. R. Kazarov, C. E. Butterfield, B. D. Hopkins, L. E. Benjamin, A. Kaipainen, and M. E. Hemler Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro Blood, February 15, 2007; 109(4): 1524 - 1532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ramont, S. Brassart-Pasco, J. Thevenard, A. Deshorgue, L. Venteo, J. Y. Laronze, M. Pluot, J.-C. Monboisse, and F.-X. Maquart The NC1 domain of type XIX collagen inhibits in vivo melanoma growth Mol. Cancer Ther., February 1, 2007; 6(2): 506 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-S. Lee, S.-A. Yoo, C.-S. Cho, P.-G. Suh, W.-U. Kim, and S. H. Ryu Serum Amyloid A Binding to Formyl Peptide Receptor-Like 1 Induces Synovial Hyperplasia and Angiogenesis J. Immunol., October 15, 2006; 177(8): 5585 - 5594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Chabottaux, N. E. Sounni, C. J. Pennington, W. R. English, F. van den Brule, S. Blacher, C. Gilles, C. Munaut, E. Maquoi, C. Lopez-Otin, et al. Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases. Cancer Res., May 15, 2006; 66(10): 5165 - 5172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chakraborty, H. Rangaswami, S. Jain, and G. C. Kundu Hypoxia Regulates Cross-talk between Syk and Lck Leading to Breast Cancer Progression and Angiogenesis J. Biol. Chem., April 21, 2006; 281(16): 11322 - 11331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. W.M. van Hinsbergh, M. A. Engelse, and P. H.A. Quax Pericellular Proteases in Angiogenesis and Vasculogenesis Arterioscler Thromb Vasc Biol, April 1, 2006; 26(4): 716 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Plaisier, P. Koolwijk, R. Hanemaaijer, R. A. Verwey, R. M.F. van der Weiden, E. K.J. Risse, C. Jungerius, F. M. Helmerhorst, and V. W.M. van Hinsbergh Membrane-type matrix metalloproteinases and vascularization in human endometrium during the menstrual cycle Mol. Hum. Reprod., January 1, 2006; 12(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Polette, C. Gilles, B. Nawrocki-Raby, J. Lohi, W. Hunziker, J.-M. Foidart, and P. Birembaut Membrane-Type 1 Matrix Metalloproteinase Expression Is Regulated by Zonula Occludens-1 in Human Breast Cancer Cells Cancer Res., September 1, 2005; 65(17): 7691 - 7698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Smola-Hess, J. Pahne, C. Mauch, P. Zigrino, H. Smola, and H. J. Pfister Expression of membrane type 1 matrix metalloproteinase in papillomavirus-positive cells: role of the human papillomavirus (HPV) 16 and HPV8 E7 gene products J. Gen. Virol., May 1, 2005; 86(5): 1291 - 1296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Voskas, N. Jones, P. Van Slyke, C. Sturk, W. Chang, A. Haninec, Y. O. Babichev, J. Tran, Z. Master, S. Chen, et al. A Cyclosporine-Sensitive Psoriasis-Like Disease Produced in Tie2 Transgenic Mice Am. J. Pathol., March 1, 2005; 166(3): 843 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. McMahon, F. Grondin, P. P. McDonald, D. E. Richard, and C. M. Dubois Hypoxia-enhanced Expression of the Proprotein Convertase Furin Is Mediated by Hypoxia-inducible Factor-1: IMPACT ON THE BIOACTIVATION OF PROPROTEINS J. Biol. Chem., February 25, 2005; 280(8): 6561 - 6569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Rozanov, A. Y. Savinov, V. S. Golubkov, T. I. Postnova, A. Remacle, S. Tomlinson, and A. Y. Strongin Cellular Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Cleaves C3b, an Essential Component of the Complement System J. Biol. Chem., November 5, 2004; 279(45): 46551 - 46557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Plaisier, K. Kapiteijn, P. Koolwijk, C. Fijten, R. Hanemaaijer, J. M. Grimbergen, A. Mulder-Stapel, P. H. A. Quax, F. M. Helmerhorst, and V. W. M. van Hinsbergh Involvement of Membrane-Type Matrix Metalloproteinases (MT-MMPs) in Capillary Tube Formation by Human Endometrial Microvascular Endothelial Cells: Role of MT3-MMP J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5828 - 5836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Maquoi, N. E. Sounni, L. Devy, F. Olivier, F. Frankenne, H.-W. Krell, F. Grams, J.-M. Foidart, and A. Noel Anti-Invasive, Antitumoral, and Antiangiogenic Efficacy of a Pyrimidine-2,4,6-trione Derivative, an Orally Active and Selective Matrix Metalloproteinases Inhibitor Clin. Cancer Res., June 15, 2004; 10(12): 4038 - 4047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Noel, C Maillard, N Rocks, M Jost, V Chabottaux, N E Sounni, E Maquoi, D Cataldo, and J M Foidart Membrane associated proteases and their inhibitors in tumour angiogenesis J. Clin. Pathol., June 1, 2004; 57(6): 577 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Lee, M. Rapti, V. Knauper, and G. Murphy Threonine 98, the Pivotal Residue of Tissue Inhibitor of Metalloproteinases (TIMP)-1 in Metalloproteinase Recognition J. Biol. Chem., April 23, 2004; 279(17): 17562 - 17569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Sounni, C. Roghi, V. Chabottaux, M. Janssen, C. Munaut, E. Maquoi, B. G. Galvez, C. Gilles, F. Frankenne, G. Murphy, et al. Up-regulation of Vascular Endothelial Growth Factor-A by Active Membrane-type 1 Matrix Metalloproteinase through Activation of Src-Tyrosine Kinases J. Biol. Chem., April 2, 2004; 279(14): 13564 - 13574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Tester, M. Waltham, S.-J. Oh, S.-N. Bae, M. M. Bills, E. C. Walker, F. G. Kern, W. G. Stetler-Stevenson, M. E. Lippman, and E. W. Thompson Pro-Matrix Metalloproteinase-2 Transfection Increases Orthotopic Primary Growth and Experimental Metastasis of MDA-MB-231 Human Breast Cancer Cells in Nude Mice Cancer Res., January 15, 2004; 64(2): 652 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. N. Ye, E. S. L. Liu, V. Y. Shin, W. K. K. Wu, J. C. Luo, and C. H. Cho Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway J. Pharmacol. Exp. Ther., January 1, 2004; 308(1): 66 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Garvin and C. Dabrosin Tamoxifen Inhibits Secretion of Vascular Endothelial Growth Factor in Breast Cancer in Vivo Cancer Res., December 15, 2003; 63(24): 8742 - 8748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ohno-Matsui, T. Uetama, T. Yoshida, M. Hayano, T. Itoh, I. Morita, and M. Mochizuki Reduced Retinal Angiogenesis in MMP-2-Deficient Mice Invest. Ophthalmol. Vis. Sci., December 1, 2003; 44(12): 5370 - 5375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Remacle, G. Murphy, and C. Roghi Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface J. Cell Sci., October 1, 2003; 116(19): 3905 - 3916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-W. Wang, H. Chang, S. Lin, P. Kuan, and K.-G. Shyu Induction of matrix metalloproteinases-14 and -2 by cyclical mechanical stretch is mediated by tumor necrosis factor-{alpha} in cultured human umbilical vein endothelial cells Cardiovasc Res, August 1, 2003; 59(2): 460 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. SOMLYO, C. PHELPS, C. DIPIERRO, M. ETO, P. READ, M. BARRETT, J. J. GIBSON, M. C. BURNITZ, C. MYERS, and A. P. SOMLYO Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants FASEB J, February 1, 2003; 17(2): 223 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Arlt, C. Kopitz, C. Pennington, K. L. M. Watson, H.-W. Krell, W. Bode, B. Gansbacher, R. Khokha, D. R. Edwards, and A. Kruger Increase in Gelatinase-specificity of Matrix Metalloproteinase Inhibitors Correlates with Antimetastatic Efficacy in a T-Cell Lymphoma Model Cancer Res., October 1, 2002; 62(19): 5543 - 5550. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
