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MHC and MHC-related proteins as pleiotropic signal molecules

DAVID M. OJCIUS^*, CHRISTIANE DELARBRE, PHILIPPE KOURILSKY and GABRIEL GACHELIN¹

Unité de Biologie Moléculaire du Gène de l’Institut Pasteur,
^* Université Paris 7, and
INSERM U277, Institut Pasteur, 75724 Paris cedex 15, France

¹Correspondence: Unité de Biologie Moléculaire du Gène, Institut Pasteur, 25 rue du Dr. Roux, 75015 Paris. E-mail: ggachel{at}pasteur.fr

Class I molecules of the major histocompatibility complex (MHC) have been studied primarily for their role in presenting peptide antigens to conventional T lymphocytes. An increasing body of evidence suggests that MHC and newly characterized MHC-related molecules have a much more varied function in the body. Many of these molecules are involved in pleiotropic interactions with other proteins, which initiate signal transduction cascades and contribute to cellular and tissue homeostasis.—Ojcius, D. M., Delarbre, C., Kourilsky, P., Gachelin, G. MHC and MHC-related proteins as pleiotropic signal molecules.

Key Words: signal transduction • homeostasis • protein–protein interaction • MHC class I

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