| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Biology, York University, Toronto, Canada;
* Integrative Physiology, Karolinska Institute, Stockholm, Sweden; and
Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
1Correspondence: Department of Biology, York University, Toronto, M3J 1P3 Ontario, Canada. E-mail: gsweeney{at}yorku.ca
Obesity is commonly associated with the development of insulin resistance and diabetes in humans and rodents. Insulin resistance and diabetes are observed in lipoatrophic individuals or rodent models of lipoatrophy. Here we focus on the role of leptin, the product of the obesity (ob) gene, in the development of insulin resistance and diabetes associated with obesity and lipoatrophy. We review the reported effects of leptin on whole body glucose metabolism and compare and contrast these with direct effects on skeletal muscle, fat and liver. This summary of paradoxical observations on the effects of leptin on glucose homeostasis and the ability of leptin to induce or improve insulin resistance suggests that a complex interplay exists between direct peripheral and centrally mediated effects of the hormone. Evidence suggesting that leptin acts as a mediator of insulin release from pancreatic ß cells is reviewed. Finally, intracellular signaling mechanisms stimulated by both leptin and insulin are discussed, with potential points of cross-talk suggested.—Ceddia, R. B., Koistinen, H. A., Zierath, J. R., Sweeney, G. Analysis of paradoxical observations on the association between leptin and insulin resistance.
Key Words: obesity • lipoatrophy • lipodystrophy • diabetes mellitus • glucose metabolism
This article has been cited by other articles:
|
|
 |
|
  Q. Sun, R. M. van Dam, J. B. Meigs, O. H. Franco, C. S. Mantzoros, and F. B. Hu Leptin and Soluble Leptin Receptor Levels in Plasma and Risk of Type 2 Diabetes in U.S. Women: A Prospective Study Diabetes, March 1, 2010; 59(3): 611 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ratke, F. Entschladen, B. Niggemann, K. S Zanker, and K. Lang Leptin stimulates the migration of colon carcinoma cells by multiple signaling pathways Endocr. Relat. Cancer, February 18, 2010; 17(1): 179 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delibegovic, D. Zimmer, C. Kauffman, K. Rak, E.-G. Hong, Y.-R. Cho, J. K. Kim, B. B. Kahn, B. G. Neel, and K. K. Bence Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress Diabetes, March 1, 2009; 58(3): 590 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Palanivel, V. Vu, M. Park, X. Fang, and G. Sweeney Differential impact of adipokines derived from primary adipocytes of wild-type versus streptozotocin-induced diabetic rats on glucose and fatty acid metabolism in cardiomyocytes J. Endocrinol., December 1, 2008; 199(3): 389 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Paz-Filho, K. Esposito, B. Hurwitz, A. Sharma, C. Dong, V. Andreev, T. Delibasi, H. Erol, A. Ayala, M.-L. Wong, et al. Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients Am J Physiol Endocrinol Metab, December 1, 2008; 295(6): E1401 - E1408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Ueland, T Dalsoren, N Voldner, K Godang, T Henriksen, and J Bollerslev Retinol-binding protein-4 is not strongly associated with insulin sensitivity in normal pregnancies. Eur. J. Endocrinol., July 1, 2008; 159(1): 49 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. F. Chehab Minireview: Obesity and LipOdystrophy--Where Do the Circles Intersect? Endocrinology, March 1, 2008; 149(3): 925 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Vu, W. Kim, X. Fang, Y.-T. Liu, A. Xu, and G. Sweeney Coculture with Primary Visceral Rat Adipocytes from Control But Not Streptozotocin-Induced Diabetic Animals Increases Glucose Uptake in Rat Skeletal Muscle Cells: Role of Adiponectin Endocrinology, September 1, 2007; 148(9): 4411 - 4419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Cohen, E. Kokkotou, S. B. Biddinger, T. Kondo, R. Gebhardt, J. Kratzsch, C. S. Mantzoros, and C. R. Kahn High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-specific Insulin Receptor Knock-out (LIRKO) Mice J. Biol. Chem., August 10, 2007; 282(32): 23672 - 23678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Dimitriadis, P. Mitrou, V. Lambadiari, E. Boutati, E. Maratou, D. B. Panagiotakos, E. Koukkou, M. Tzanela, N. Thalassinos, and S. A. Raptis Insulin Action in Adipose Tissue and Muscle in Hypothyroidism J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4930 - 4937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C Saleh, M. B Wheeler, and C. B Chan Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice. J. Endocrinol., September 1, 2006; 190(3): 659 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Fraenkel, J Caloyeras, S-G Ren, and S Melmed Sex-steroid milieu determines diabetes rescue in pttg-null mice. J. Endocrinol., June 1, 2006; 189(3): 519 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Hennige, N. Stefan, K. Kapp, R. Lehmann, C. Weigert, A. Beck, K. Moeschel, J. Mushack, E. Schleicher, and H.-U. Haring Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1 FASEB J, June 1, 2006; 20(8): 1206 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lopez-Soriano, C. Chiellini, M. Maffei, P. A. Grimaldi, and J. M. Argiles Roles of Skeletal Muscle and Peroxisome Proliferator-Activated Receptors in the Development and Treatment of Obesity Endocr. Rev., May 1, 2006; 27(3): 318 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Punjabi and V. Y. Polotsky Disorders of glucose metabolism in sleep apnea J Appl Physiol, November 1, 2005; 99(5): 1998 - 2007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Klebanov, C. M Astle, O. DeSimone, V. Ablamunits, and D. E Harrison Adipose tissue transplantation protects ob/ob mice from obesity, normalizes insulin sensitivity and restores fertility J. Endocrinol., July 1, 2005; 186(1): 203 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Perego, P. Pizzocri, D. Corradi, F. Maisano, M. Paganelli, P. Fiorina, M. Barbieri, A. Morabito, G. Paolisso, F. Folli, et al. Circulating Leptin Correlates with Left Ventricular Mass in Morbid (Grade III) Obesity before and after Weight Loss Induced by Bariatric Surgery: A Potential Role for Leptin in Mediating Human Left Ventricular Hypertrophy J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4087 - 4093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Kramer, L. Al-Khalili, S. Perrini, J. Skogsberg, P. Wretenberg, K. Kannisto, H. Wallberg-Henriksson, E. Ehrenborg, J. R. Zierath, and A. Krook Direct Activation of Glucose Transport in Primary Human Myotubes After Activation of Peroxisome Proliferator-Activated Receptor {delta} Diabetes, April 1, 2005; 54(4): 1157 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Barazzoni, M. Zanetti, A. Bosutti, G. Biolo, L. Vitali-Serdoz, M. Stebel, and G. Guarnieri Moderate Caloric Restriction, But Not Physiological Hyperleptinemia Per Se, Enhances Mitochondrial Oxidative Capacity in Rat Liver and Skeletal Muscle--Tissue-Specific Impact on Tissue Triglyceride Content and AKT Activation Endocrinology, April 1, 2005; 146(4): 2098 - 2106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Duivenvoorden, B. Teusink, P. C. Rensen, J. A. Romijn, L. M. Havekes, and P. J. Voshol Apolipoprotein C3 Deficiency Results in Diet-Induced Obesity and Aggravated Insulin Resistance in Mice Diabetes, March 1, 2005; 54(3): 664 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yu, K. Ohmori, Y. Chen, C. Sato, H. Kiyomoto, K. Shinomiya, H. Takeuchi, K. Mizushige, and M. Kohno Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model J. Am. Coll. Cardiol., August 18, 2004; 44(4): 904 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Perez, C. Fernandez-Galaz, T. Fernandez-Agullo, C. Arribas, A. Andres, M. Ros, and J. M. Carrascosa Leptin Impairs Insulin Signaling in Rat Adipocytes Diabetes, February 1, 2004; 53(2): 347 - 353. [Abstract] [Full Text]
|
|
|
|
 |
|
 V. Y Polotsky, J. Li, N. M Punjabi, A. E Rubin, P. L Smith, A. R Schwartz, and C. P O'Donnell Intermittent Hypoxia Increases Insulin Resistance in Genetically Obese Mice J. Physiol., October 1, 2003; 552(1): 253 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Barouch, D. E. Berkowitz, R. W. Harrison, C. P. O'Donnell, and J. M. Hare Disruption of Leptin Signaling Contributes to Cardiac Hypertrophy Independently of Body Weight in Mice Circulation, August 12, 2003; 108(6): 754 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Asante-Appiah and B. P. Kennedy Protein tyrosine phosphatases: the quest for negative regulators of insulin action Am J Physiol Endocrinol Metab, April 1, 2003; 284(4): E663 - E670. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
