| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
1Correspondence: Carl-Ludwig-Institute of Physiology, University of Leipzig, Liebigstrasse 27, D-04103 Leipzig, Germany. E-mail: wenr{at}medizin.uni-leipzig.de
Although it was known for a long time that oxygen deprivation leads to the transcriptional induction of the gene encoding erythropoietin, the molecular mechanisms behind this process remained enigmatic. The cloning of the hypoxia-inducible factors (HIFs), the finding that HIF-1 regulates the expression of many more genes apart from erythropoietin, and the elucidation of the oxygen-dependent mechanisms degrading the HIF 
subunits recently led to the spectacular discovery of the molecular principles of oxygen sensing. This review aims to summarize our current knowledge of oxygen-regulated gene expression.—Wenger, R. H. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression.
Key Words: environmental adaptation • erythropoietin • oxygen • transcriptional regulation • vascular endothelial growth factor
This article has been cited by other articles:
|
|
 |
|
  J. J. Lee, M. Natsuizaka, S. Ohashi, G. S. Wong, M. Takaoka, C. Z. Michaylira, D. Budo, J. W. Tobias, M. Kanai, Y. Shirakawa, et al. Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis Carcinogenesis, March 1, 2010; 31(3): 427 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Schietke, C. Warnecke, I. Wacker, J. Schodel, D. R. Mole, V. Campean, K. Amann, M. Goppelt-Struebe, J. Behrens, K.-U. Eckardt, et al. The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia: INSIGHTS INTO CELLULAR TRANSFORMATION PROCESSES MEDIATED BY HIF-1 J. Biol. Chem., February 26, 2010; 285(9): 6658 - 6669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E Forristal, K. L Wright, N. A Hanley, R. O C Oreffo, and F. D Houghton Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions Reproduction, January 1, 2010; 139(1): 85 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kojima, A. Kobayashi, D. Sakurai, Y. Kanno, H. Hase, R. Takahashi, Y. Totsuka, G. L. Semenza, M. V. Sitkovsky, and T. Kobata Differentiation Stage-Specific Requirement in Hypoxia-Inducible Factor-1{alpha}-Regulated Glycolytic Pathway during Murine B Cell Development in Bone Marrow J. Immunol., January 1, 2010; 184(1): 154 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Dong, Q. Wang, Y. Zhang, B. Jiang, X. Xu, and Z. Zhang Angiogenesis Induced by hVEGF165 Gene Controlled by Hypoxic Response Elements in Rabbit Ischemia Myocardium Exp Biol Med, December 1, 2009; 234(12): 1417 - 1424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-G. Ryou, D. C. Flaherty, B. Hoxha, J. Sun, H. Gurji, S. Rodriguez, G. Bell, A. H. Olivencia-Yurvati, and R. T. Mallet Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass Am J Physiol Heart Circ Physiol, November 1, 2009; 297(5): H1914 - H1922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pluteanu and L. L. Cribbs T-type calcium channels are regulated by hypoxia/reoxygenation in ventricular myocytes Am J Physiol Heart Circ Physiol, October 1, 2009; 297(4): H1304 - H1313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Poomthavorn, S. H X Wong, S. Higgins, G. A Werther, and V. C Russo Activation of a prometastatic gene expression program in hypoxic neuroblastoma cells Endocr. Relat. Cancer, September 1, 2009; 16(3): 991 - 1004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Rankin, J. Rha, M. A. Selak, T. L. Unger, B. Keith, Q. Liu, and V. H. Haase Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism Mol. Cell. Biol., August 15, 2009; 29(16): 4527 - 4538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Levy, M. R. Bonsignore, and J. Eckel Sleep, sleep-disordered breathing and metabolic consequences Eur. Respir. J., July 1, 2009; 34(1): 243 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Mole, C. Blancher, R. R. Copley, P. J. Pollard, J. M. Gleadle, J. Ragoussis, and P. J. Ratcliffe Genome-wide Association of Hypoxia-inducible Factor (HIF)-1{alpha} and HIF-2{alpha} DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts J. Biol. Chem., June 19, 2009; 284(25): 16767 - 16775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kudo, M. Ueda, Y. Kuge, T. Mukai, S. Tanaka, M. Masutani, Y. Kiyono, S. Kizaka-Kondoh, M. Hiraoka, and H. Saji Imaging of HIF-1-Active Tumor Hypoxia Using a Protein Effectively Delivered to and Specifically Stabilized in HIF-1-Active Tumor Cells J. Nucl. Med., June 1, 2009; 50(6): 942 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Paul, S. Teng, and P. T.K. Saunders A Single, Mild, Transient Scrotal Heat Stress Causes Hypoxia and Oxidative Stress in Mouse Testes, Which Induces Germ Cell Death Biol Reprod, May 1, 2009; 80(5): 913 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Schwartz, G. Powis, A. Thitai-Kumar, Y. He, J. Bankson, R. Williams, R. Lemos, J. Oh, A. Volgin, S. Soghomonyan, et al. The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects Mol. Cancer Ther., April 1, 2009; 8(4): 947 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Czibik, J. Sagave, V. Martinov, B. Ishaq, M. Sohl, I. Sefland, H. Carlsen, F. Farnebo, R. Blomhoff, and G. Valen Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice Cardiovasc Res, April 1, 2009; 82(1): 107 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Puri, D. A. Cano, and M. Hebrok A Role for von Hippel-Lindau Protein in Pancreatic {beta}-Cell Function Diabetes, February 1, 2009; 58(2): 433 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. X. Knaup, K. Jozefowski, R. Schmidt, W. M. Bernhardt, A. Weidemann, J. S. Juergensen, C. Warnecke, K.-U. Eckardt, and M. S. Wiesener Mutual Regulation of Hypoxia-Inducible Factor and Mammalian Target of Rapamycin as a Function of Oxygen Availability Mol. Cancer Res., January 1, 2009; 7(1): 88 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F M E Franssen, D E O'Donnell, G H Goossens, E E Blaak, and A M W J Schols Obesity and the lung: 5 {middle dot} Obesity and COPD Thorax, December 1, 2008; 63(12): 1110 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wirthner, S. Wrann, K. Balamurugan, R. H. Wenger, and D. P. Stiehl Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1{alpha}-deficient mouse embryonic fibroblasts Carcinogenesis, December 1, 2008; 29(12): 2306 - 2316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Shibata, K. Nakagawa, P. Sookwong, T. Tsuduki, S. Tomita, H. Shirakawa, M. Komai, and T. Miyazawa Tocotrienol Inhibits Secretion of Angiogenic Factors from Human Colorectal Adenocarcinoma Cells by Suppressing Hypoxia-Inducible Factor-1{alpha} J. Nutr., November 1, 2008; 138(11): 2136 - 2142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rabie and H. H. Marti Brain Protection by Erythropoietin: A Manifold Task Physiology, October 1, 2008; 23(5): 263 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Fitsialos, I. Bourget, S. Augier, A. Ginouves, R. Rezzonico, T. Odorisio, F. Cianfarani, T. Virolle, J. Pouyssegur, G. Meneguzzi, et al. HIF1 transcription factor regulates laminin-332 expression and keratinocyte migration J. Cell Sci., September 15, 2008; 121(18): 2992 - 3001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Klein, D. Flugel, and T. Kietzmann Transcriptional Regulation of Serine/Threonine Kinase-15 (STK15) Expression by Hypoxia and HIF-1 Mol. Biol. Cell, September 1, 2008; 19(9): 3667 - 3675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, L. Xiao, J. N. Rao, T. Zou, L. Liu, E. Bellavance, M. Gorospe, and J.-Y. Wang JunD Represses Transcription and Translation of the Tight Junction Protein Zona Occludens-1 Modulating Intestinal Epithelial Barrier Function Mol. Biol. Cell, September 1, 2008; 19(9): 3701 - 3712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ream, A. M. Ray, R. Chandra, and D. M. Chikaraishi Early fetal hypoxia leads to growth restriction and myocardial thinning Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R583 - R595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. A. Minamishima, J. Moslehi, N. Bardeesy, D. Cullen, R. T. Bronson, and W. G. Kaelin Jr Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure Blood, March 15, 2008; 111(6): 3236 - 3244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Walmsley, N. N. McGovern, M. K. B. Whyte, and E. R. Chilvers The HIF/VHL Pathway: From Oxygen Sensing to Innate Immunity Am. J. Respir. Cell Mol. Biol., March 1, 2008; 38(3): 251 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Casals-Pascual, R. Idro, N. Gicheru, S. Gwer, B. Kitsao, E. Gitau, R. Mwakesi, D. J. Roberts, and C. R. J. C. Newton High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria PNAS, February 19, 2008; 105(7): 2634 - 2639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Ray, S. Arab, Y. Deng, P. Liu, L. Penn, D. W. Courtman, and M. E. Ward Oxygen regulation of arterial smooth muscle cell proliferation and survival Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H839 - H852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Lin, C. A. David, J. B. Donnelly, M. Michaelides, N. S. Chandel, X. Huang, U. Warrior, F. Weinberg, K. V. Tormos, S. W. Fesik, et al. A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation PNAS, January 8, 2008; 105(1): 174 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Charbonneau, K. Harper, F. Grondin, M. Pelmus, P. P. McDonald, and C. M. Dubois Hypoxia-inducible Factor Mediates Hypoxic and Tumor Necrosis Factor {alpha}-induced Increases in Tumor Necrosis Factor-{alpha} Converting Enzyme/ADAM17 Expression by Synovial Cells J. Biol. Chem., November 16, 2007; 282(46): 33714 - 33724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Essop Cardiac metabolic adaptations in response to chronic hypoxia J. Physiol., November 1, 2007; 584(3): 715 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Echevarria, A. M. Munoz-Cabello, R. Sanchez-Silva, J. J. Toledo-Aral, and J. Lopez-Barneo Development of Cytosolic Hypoxia and Hypoxia-inducible Factor Stabilization Are Facilitated by Aquaporin-1 Expression J. Biol. Chem., October 12, 2007; 282(41): 30207 - 30215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Natarajan, F. N. Salloum, B. J. Fisher, E. D. Ownby, R. C. Kukreja, and A. A. Fowler 3rd Activation of hypoxia-inducible factor-1 via prolyl-4 hydoxylase-2 gene silencing attenuates acute inflammatory responses in postischemic myocardium Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1571 - H1580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Fouassier, M. Beaussier, E. Schiffer, C. Rey, V. Barbu, M. Mergey, D. Wendum, P. Callard, J.-Y. Scoazec, E. Lasnier, et al. Hypoxia-induced changes in the expression of rat hepatobiliary transporter genes Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G25 - G35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Oh, J. K. Woo, Y. D. Yazici, J. N. Myers, W.-Y. Kim, Q. Jin, S. S. Hong, H.-J. Park, Y.-G. Suh, K.-W. Kim, et al. Structural Basis for Depletion of Heat Shock Protein 90 Client Proteins by Deguelin J Natl Cancer Inst, June 20, 2007; 99(12): 949 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nikinmaa and W. Waser Molecular and cellular studies in evolutionary physiology of natural vertebrate populations: influences of individual variation and genetic components on sampling and measurements J. Exp. Biol., June 1, 2007; 210(11): 1847 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Barth, J. Nesper, P. A. Hasgall, R. Wirthner, K. J. Nytko, F. Edlich, D. M. Katschinski, D. P. Stiehl, R. H. Wenger, and G. Camenisch The Peptidyl Prolyl cis/trans Isomerase FKBP38 Determines Hypoxia-Inducible Transcription Factor Prolyl-4-Hydroxylase PHD2 Protein Stability Mol. Cell. Biol., May 15, 2007; 27(10): 3758 - 3768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Flugel, A. Gorlach, C. Michiels, and T. Kietzmann Glycogen Synthase Kinase 3 Phosphorylates Hypoxia-Inducible Factor 1{alpha} and Mediates Its Destabilization in a VHL-Independent Manner Mol. Cell. Biol., May 1, 2007; 27(9): 3253 - 3265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Kazi and R. D. Koos Estrogen-Induced Activation of Hypoxia-Inducible Factor-1{alpha}, Vascular Endothelial Growth Factor Expression, and Edema in the Uterus Are Mediated by the Phosphatidylinositol 3-Kinase/Akt Pathway Endocrinology, May 1, 2007; 148(5): 2363 - 2374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, K. Uchida, A. Endler, and F. Shibasaki Mammalian Tumor Suppressor Int6 Specifically Targets Hypoxia Inducible Factor 2{alpha} for Degradation by Hypoxia- and pVHL-independent Regulation J. Biol. Chem., April 27, 2007; 282(17): 12707 - 12716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kojima, T. Tanaka, R. Inagi, H. Kato, T. Yamashita, A. Sakiyama, O. Ohneda, N. Takeda, M. Sata, T. Miyata, et al. Protective Role of Hypoxia-Inducible Factor-2{alpha} against Ischemic Damage and Oxidative Stress in the Kidney J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1218 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhou, D. K. Ann, X. Li, K.-J. Kim, H. Lin, P. Minoo, E. D. Crandall, and Z. Borok Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1{alpha} Am J Physiol Cell Physiol, April 1, 2007; 292(4): C1280 - C1290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Puppo, M. C. Bosco, M. Federico, S. Pastorino, and L. Varesio Hypoxia inhibits Moloney murine leukemia virus expression in activated macrophages J. Leukoc. Biol., February 1, 2007; 81(2): 528 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Milosevic, M. Maisel, F. Wegner, J. Leuchtenberger, R. H. Wenger, M. Gerlach, A. Storch, and J. Schwarz Lack of Hypoxia-Inducible Factor-1{alpha} Impairs Midbrain Neural Precursor Cells Involving Vascular Endothelial Growth Factor Signaling J. Neurosci., January 10, 2007; 27(2): 412 - 421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rosenberger, J. Pratschke, B. Rudolph, S. N. Heyman, R. Schindler, N. Babel, K.-U. Eckardt, U. Frei, S. Rosen, and P. Reinke Immunohistochemical Detection of Hypoxia-Inducible Factor-1{alpha} in Human Renal Allograft Biopsies J. Am. Soc. Nephrol., January 1, 2007; 18(1): 343 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Ke and M. Costa Hypoxia-Inducible Factor-1 (HIF-1) Mol. Pharmacol., November 1, 2006; 70(5): 1469 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Shen, Z. Shao, and J. A. Powell-Coffman The Caenorhabditis elegans rhy-1 Gene Inhibits HIF-1 Hypoxia-Inducible Factor Activity in a Negative Feedback Loop That Does Not Include vhl-1 Genetics, November 1, 2006; 174(3): 1205 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Walmsley, A. S. Cowburn, M. R. Clatworthy, N. W. Morrell, E. C. Roper, V. Singleton, P. Maxwell, M. K. B. Whyte, and E. R. Chilvers Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis Blood, November 1, 2006; 108(9): 3176 - 3178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kieda, R. Greferath, C. Crola Da Silva, K. C. Fylaktakidou, J.-M. Lehn, and C. Nicolau Suppression of hypoxia-induced HIF-1{alpha} and of angiogenesis in endothelial cells by myo-inositol trispyrophosphate-treated erythrocytes PNAS, October 17, 2006; 103(42): 15576 - 15581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cross, T. Barnes, R. C. Bucknall, S. W. Edwards, and R. J. Moots Neutrophil apoptosis in rheumatoid arthritis is regulated by local oxygen tensions within joints J. Leukoc. Biol., September 1, 2006; 80(3): 521 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nishimura, R. Sakumoto, Y. Tatsukawa, T. J. Acosta, and K. Okuda Oxygen Concentration Is an Important Factor for Modulating Progesterone Synthesis in Bovine Corpus Luteum Endocrinology, September 1, 2006; 147(9): 4273 - 4280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Stiehl, R. Wirthner, J. Koditz, P. Spielmann, G. Camenisch, and R. H. Wenger Increased Prolyl 4-Hydroxylase Domain Proteins Compensate for Decreased Oxygen Levels: EVIDENCE FOR AN AUTOREGULATORY OXYGEN-SENSING SYSTEM J. Biol. Chem., August 18, 2006; 281(33): 23482 - 23491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hubert, S. Paris, J.-P. Piret, N. Ninane, M. Raes, and C. Michiels Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level J. Cell Sci., August 15, 2006; 119(16): 3351 - 3362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tanaka, H. Kato, I. Kojima, T. Ohse, D. Son, T. Tawakami, T. Yatagawa, R. Inagi, T. Fujita, and M. Nangaku Hypoxia and Expression of Hypoxia-Inducible Factor in the Aging Kidney J Gerontol A Biol Sci Med Sci, August 1, 2006; 61(8): 795 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Acker, J. Fandrey, and H. Acker The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases Cardiovasc Res, July 15, 2006; 71(2): 195 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Trayhurn, C. Bing, and I. S. Wood Adipose Tissue and Adipokines--Energy Regulation from the Human Perspective J. Nutr., July 1, 2006; 136(7): 1935S - 1939S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, M. P. Biju, M.-H. Wang, V. H. Haase, and Z. Dong Cytoprotective Effects of Hypoxia against Cisplatin-Induced Tubular Cell Apoptosis: Involvement of Mitochondrial Inhibition and p53 Suppression J. Am. Soc. Nephrol., July 1, 2006; 17(7): 1875 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Unwin, D. L. Smith, D. Blinco, C. L. Wilson, C. J. Miller, C. A. Evans, E. Jaworska, S. A. Baldwin, K. Barnes, A. Pierce, et al. Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells Blood, June 15, 2006; 107(12): 4687 - 4694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Neuhofer and F.-X. Beck Survival in Hostile Environments: Strategies of Renal Medullary Cells Physiology, June 1, 2006; 21(3): 171 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Aprelikova, M. Wood, S. Tackett, G. V.R. Chandramouli, and J. C. Barrett Role of ETS Transcription Factors in the Hypoxia-Inducible Factor-2 Target Gene Selection Cancer Res., June 1, 2006; 66(11): 5641 - 5647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Hopfer, H. Hopfer, K. Jablonski, R. A. K. Stahl, and G. Wolf The Novel WD-repeat Protein Morg1 Acts as a Molecular Scaffold for Hypoxia-inducible Factor Prolyl Hydroxylase 3 (PHD3) J. Biol. Chem., March 31, 2006; 281(13): 8645 - 8655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Rissanen, H. K. Tranberg, J. Sollid, G. E. Nilsson, and M. Nikinmaa Temperature regulates hypoxia-inducible factor-1 (HIF-1) in a poikilothermic vertebrate, crucian carp (Carassius carassius) J. Exp. Biol., March 15, 2006; 209(6): 994 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Rankin, J. E. Tomaszewski, and V. H. Haase Renal cyst development in mice with conditional inactivation of the von hippel-lindau tumor suppressor. Cancer Res., March 1, 2006; 66(5): 2576 - 2583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.L. James, P.R. Stone, and L.W. Chamley The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancy Hum. Reprod. Update, March 1, 2006; 12(2): 137 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Schaffer, J. Vogel, C. Breymann, M. Gassmann, and H. H. Marti Preserved placental oxygenation and development during severe systemic hypoxia Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R844 - R851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Amir, R. Wang, H. Matzkin, J. W. Simons, and N. J. Mabjeesh MSF-A Interacts with Hypoxia-Inducible Factor-1{alpha} and Augments Hypoxia-Inducible Factor Transcriptional Activation to Affect Tumorigenicity and Angiogenesis Cancer Res., January 15, 2006; 66(2): 856 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Natarajan, F. N. Salloum, B. J. Fisher, R. C. Kukreja, and A. A. Fowler III Hypoxia Inducible Factor-1 Activation by Prolyl 4-Hydroxylase-2 Gene Silencing Attenuates Myocardial Ischemia Reperfusion Injury Circ. Res., January 6, 2006; 98(1): 133 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Palmer Regulation of respiration and endothelial gene expression by s-nitrosothiols in health and disease. Proceedings of the ATS, January 1, 2006; 3(2): 166 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Piruat and J. Lopez-Barneo Oxygen Tension Regulates Mitochondrial DNA-encoded Complex I Gene Expression J. Biol. Chem., December 30, 2005; 280(52): 42676 - 42684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Acker The oxygen sensing signal cascade under the influence of reactive oxygen species Phil Trans R Soc B, December 29, 2005; 360(1464): 2201 - 2210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. O. Ibrahim, T. Hahn, C. Franke, D. P. Stiehl, R. Wirthner, R. H. Wenger, and D. M. Katschinski Induction of the Hypoxia-Inducible Factor System by Low Levels of Heat Shock Protein 90 Inhibitors Cancer Res., December 1, 2005; 65(23): 11094 - 11100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-G. Scharf, T. G. Unterman, and T. Kietzmann Oxygen-Dependent Modulation of Insulin-Like Growth Factor Binding Protein Biosynthesis in Primary Cultures of Rat Hepatocytes Endocrinology, December 1, 2005; 146(12): 5433 - 5443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Neumann, J. Yang, M. P. Biju, S. K. Joseph, R. S. Johnson, V. H. Haase, B. D. Freedman, and L. A. Turka Hypoxia inducible factor 1{alpha} regulates T cell receptor signal transduction PNAS, November 22, 2005; 102(47): 17071 - 17076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. W. To and L. E. Huang Suppression of Hypoxia-inducible Factor 1{alpha} (HIF-1{alpha}) Transcriptional Activity by the HIF Prolyl Hydroxylase EGLN1 J. Biol. Chem., November 11, 2005; 280(45): 38102 - 38107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Gore, W. G. Hopkins, and C. M. Burge Errors of measurement for blood volume parameters: a meta-analysis J Appl Physiol, November 1, 2005; 99(5): 1745 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Wenger, D. P. Stiehl, and G. Camenisch Integration of Oxygen Signaling at the Consensus HRE Sci. Signal., October 18, 2005; 2005(306): re12 - re12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. An and M. B. Rettig Mechanism of von Hippel-Lindau Protein-Mediated Suppression of Nuclear Factor kappa B Activity Mol. Cell. Biol., September 1, 2005; 25(17): 7546 - 7556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li, X. Lin, M. Staver, A. Shoemaker, D. Semizarov, S. W. Fesik, and Y. Shen Evaluating Hypoxia-Inducible Factor-1{alpha} as a Cancer Therapeutic Target via Inducible RNA Interference In vivo Cancer Res., August 15, 2005; 65(16): 7249 - 7258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Kazi, J. M. Jones, and R. D. Koos Chromatin Immunoprecipitation Analysis of Gene Expression in the Rat Uterus in Vivo: Estrogen-Induced Recruitment of Both Estrogen Receptor {alpha} and Hypoxia-Inducible Factor 1 to the Vascular Endothelial Growth Factor Promoter Mol. Endocrinol., August 1, 2005; 19(8): 2006 - 2019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Temes, S. Martin-Puig, B. Acosta-Iborra, M. C. Castellanos, M. Feijoo-Cuaresma, G. Olmos, J. Aragones, and M. O. Landazuri Activation of HIF-prolyl Hydroxylases by R59949, an Inhibitor of the Diacylglycerol Kinase J. Biol. Chem., June 24, 2005; 280(25): 24238 - 24244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Martin, T. Linden, D. M. Katschinski, F. Oehme, I. Flamme, C. K. Mukhopadhyay, K. Eckhardt, J. Troger, S. Barth, G. Camenisch, et al. Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation Blood, June 15, 2005; 105(12): 4613 - 4619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Shen, D. Nettleton, M. Jiang, S. K. Kim, and J. A. Powell-Coffman Roles of the HIF-1 Hypoxia-inducible Factor during Hypoxia Response in Caenorhabditis elegans J. Biol. Chem., May 27, 2005; 280(21): 20580 - 20588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ozer, L. C. Wu, and R. K. Bruick The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF) PNAS, May 24, 2005; 102(21): 7481 - 7486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Helton, J. Cui, J. R. Scheel, J. A. Ellison, C. Ames, C. Gibson, B. Blouw, L. Ouyang, I. Dragatsis, S. Zeitlin, et al. Brain-Specific Knock-Out of Hypoxia-Inducible Factor-1{alpha} Reduces Rather Than Increases Hypoxic-Ischemic Damage J. Neurosci., April 20, 2005; 25(16): 4099 - 4107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Rankin, D. F. Higgins, J. A. Walisser, R. S. Johnson, C. A. Bradfield, and V. H. Haase Inactivation of the Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Suppresses von Hippel-Lindau Disease-Associated Vascular Tumors in Mice Mol. Cell. Biol., April 15, 2005; 25(8): 3163 - 3172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yun, M. Lee, S.-S. Kim, and J. Ha Glucose Deprivation Increases mRNA Stability of Vascular Endothelial Growth Factor through Activation of AMP-activated Protein Kinase in DU145 Prostate Carcinoma J. Biol. Chem., March 18, 2005; 280(11): 9963 - 9972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. McMahon, F. Grondin, P. P. McDonald, D. E. Richard, and C. M. Dubois Hypoxia-enhanced Expression of the Proprotein Convertase Furin Is Mediated by Hypoxia-inducible Factor-1: IMPACT ON THE BIOACTIVATION OF PROPROTEINS J. Biol. Chem., February 25, 2005; 280(8): 6561 - 6569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Yuan, J. Nanduri, C. R. Bhasker, G. L. Semenza, and N. R. Prabhakar Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia J. Biol. Chem., February 11, 2005; 280(6): 4321 - 4328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lluis, A. Morales, C. Blasco, A. Colell, M. Mari, C. Garcia-Ruiz, and J. C. Fernandez-Checa Critical Role of Mitochondrial Glutathione in the Survival of Hepatocytes during Hypoxia J. Biol. Chem., February 4, 2005; 280(5): 3224 - 3232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kajimura, K. Aida, and C. Duan From the Cover: Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation PNAS, January 25, 2005; 102(4): 1240 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Walmsley, C. Print, N. Farahi, C. Peyssonnaux, R. S. Johnson, T. Cramer, A. Sobolewski, A. M. Condliffe, A. S. Cowburn, N. Johnson, et al. Hypoxia-induced neutrophil survival is mediated by HIF-1{alpha}-dependent NF-{kappa}B activity J. Exp. Med., January 3, 2005; 201(1): 105 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Liu, U. Moller, D. Flugel, and T. Kietzmann Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1 Blood, December 15, 2004; 104(13): 3993 - 4001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. Rathmell, M. M. Hickey, N. A. Bezman, C. A. Chmielecki, N. C. Carraway, and M. C. Simon In vitro and In vivo Models Analyzing von Hippel-Lindau Disease-Specific Mutations Cancer Res., December 1, 2004; 64(23): 8595 - 8603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-T. Hwang, M. Lee, S.-N. Jung, H.-J. Lee, I. Kang, S.-S. Kim, and J. Ha AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1{alpha} expression in DU145 cells Carcinogenesis, December 1, 2004; 25(12): 2497 - 2507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Morita, K. Iizuka, K. Okita, T. Oikawa, K. Yonezawa, T. Nagai, Y. Tokumitsu, T. Murakami, A. Kitabatake, and H. Kawaguchi Exposure to pressure stimulus enhances succinate dehydrogenase activity in L6 myoblasts Am J Physiol Endocrinol Metab, December 1, 2004; 287(6): E1064 - E1069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chachami, G. Simos, A. Hatziefthimiou, S. Bonanou, P.-A. Molyvdas, and E. Paraskeva Cobalt Induces Hypoxia-Inducible Factor-1{alpha} Expression in Airway Smooth Muscle Cells by a Reactive Oxygen Species- and PI3K-Dependent Mechanism Am. J. Respir. Cell Mol. Biol., November 1, 2004; 31(5): 544 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Li and A. M Shah Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1014 - R1030. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
