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Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
1Correspondence: Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. E-mail: martin.bootman{at}bbsrc.ac.uk
Since its introduction to Ca2+ signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies to probe for the involvement of inositol 1,4,5-trisphosphate receptors in the generation of Ca2+ signals. Due to reports of some nonspecific actions of 2-APB, and the fact that its principal antagonistic effect is on Ca2+ entry rather than Ca2+ release, this compound may not have the utility first suggested. However, 2-APB has thrown up some interesting results, particularly with respect to store-operated Ca2+ entry in nonexcitable cells. These data indicate that although it must be used with caution, 2-APB can be useful in probing certain aspects of Ca2+ signaling.—Bootman, M. D., Collins, T. J., Mackenzie, L., Roderick, H. L., Berridge, M. J., Peppiatt, C. M. 2-Aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release.
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 T. H. Landowski, C. J. Megli, K. D. Nullmeyer, R. M. Lynch, and R. T. Dorr Mitochondrial-Mediated Disregulation of Ca2+ Is a Critical Determinant of Velcade (PS-341/Bortezomib) Cytotoxicity in Myeloma Cell Lines Cancer Res., May 1, 2005; 65(9): 3828 - 3836. [Abstract] [Full Text] [PDF]
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Q. Gu, R.-L. Lin, H.-Z. Hu, M. X. Zhu, and L.-Y. Lee 2-Aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L932 - L941. [Abstract] [Full Text] [PDF]
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M.-K. Chung, A. D. Guler, and M. J. Caterina Biphasic Currents Evoked by Chemical or Thermal Activation of the Heat-gated Ion Channel, TRPV3 J. Biol. Chem., April 22, 2005; 280(16): 15928 - 15941. [Abstract] [Full Text] [PDF]
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P. K. Aley, K. E. Porter, J. P. Boyle, P. J. Kemp, and C. Peers Hypoxic Modulation of Ca2+ Signaling in Human Venous Endothelial Cells: MULTIPLE ROLES FOR REACTIVE OXYGEN SPECIES J. Biol. Chem., April 8, 2005; 280(14): 13349 - 13354. [Abstract] [Full Text] [PDF]
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P. Georgiev, I. Garcia-Murillas, D. Ulahannan, R. C. Hardie, and P. Raghu Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant J. Cell Sci., April 1, 2005; 118(7): 1373 - 1384. [Abstract] [Full Text] [PDF]
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Y. V. Bobkov and B. W. Ache Pharmacological Properties and Functional Role of a TRP-Related Ion Channel in Lobster Olfactory Receptor Neurons J Neurophysiol, March 1, 2005; 93(3): 1372 - 1380. [Abstract] [Full Text] [PDF]
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A. M. Sakwe, L. Rask, and E. Gylfe Protein Kinase C Modulates Agonist-sensitive Release of Ca2+ from Internal Stores in HEK293 Cells Overexpressing the Calcium Sensing Receptor J. Biol. Chem., February 11, 2005; 280(6): 4436 - 4441. [Abstract] [Full Text] [PDF]
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M Estrada, A Espinosa, C J Gibson, P Uhlen, and E Jaimovich Capacitative calcium entry in testosterone-induced intracellular calcium oscillations in myotubes J. Endocrinol., February 1, 2005; 184(2): 371 - 379. [Abstract] [Full Text] [PDF]
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 H.-N. Liu, S. Ohya, S. Furuzono, J. Wang, Y. Imaizumi, and S. Nakayama Co-contribution of IP3R and Ca{superscript 2}+ Influx Pathways to Pacemaker Ca{superscript 2}+ Activity in Stomach ICC J Biol Rhythms, February 1, 2005; 20(1): 15 - 26. [Abstract] [PDF]
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G. E. Hermann, J. S. Nasse, and R. C. Rogers {alpha}-1 adrenergic input to solitary nucleus neurones: calcium oscillations, excitation and gastric reflex control J. Physiol., January 15, 2005; 562(2): 553 - 568. [Abstract] [Full Text] [PDF]
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 A. Verkhratsky Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons Physiol Rev, January 1, 2005; 85(1): 201 - 279. [Abstract] [Full Text] [PDF]
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O. Dyachok and E. Gylfe Ca2+-induced Ca2+ Release via Inositol 1,4,5-trisphosphate Receptors Is Amplified by Protein Kinase A and Triggers Exocytosis in Pancreatic {beta}-Cells J. Biol. Chem., October 29, 2004; 279(44): 45455 - 45461. [Abstract] [Full Text] [PDF]
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T. A. Goraya, N. Masada, A. Ciruela, and D. M. F. Cooper Sustained Entry of Ca2+ Is Required to Activate Ca2+-Calmodulin-dependent Phosphodiesterase 1A J. Biol. Chem., September 24, 2004; 279(39): 40494 - 40504. [Abstract] [Full Text] [PDF]
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S. I. Zakharov, T. Smani, Y. Dobrydneva, F. Monje, C. Fichandler, P. F. Blackmore, and V. M. Bolotina Diethylstilbestrol Is a Potent Inhibitor of Store-Operated Channels and Capacitative Ca2+ Influx Mol. Pharmacol., September 1, 2004; 66(3): 702 - 707. [Abstract] [Full Text] [PDF]
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H.-Z. Hu, Q. Gu, C. Wang, C. K. Colton, J. Tang, M. Kinoshita-Kawada, L.-Y. Lee, J. D. Wood, and M. X. Zhu 2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3 J. Biol. Chem., August 20, 2004; 279(34): 35741 - 35748. [Abstract] [Full Text] [PDF]
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S. Treves, C. Franzini-Armstrong, L. Moccagatta, C. Arnoult, C. Grasso, A. Schrum, S. Ducreux, M. X. Zhu, K. Mikoshiba, T. Girard, et al. Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion J. Cell Biol., August 16, 2004; 166(4): 537 - 548. [Abstract] [Full Text] [PDF]
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M.-K. Chung, H. Lee, A. Mizuno, M. Suzuki, and M. J. Caterina 2-Aminoethoxydiphenyl Borate Activates and Sensitizes the Heat-Gated Ion Channel TRPV3 J. Neurosci., June 2, 2004; 24(22): 5177 - 5182. [Abstract] [Full Text] [PDF]
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M. Aoyama, A. Yamada, J. Wang, S. Ohya, S. Furuzono, T. Goto, S. Hotta, Y. Ito, T. Matsubara, K. Shimokata, et al. Requirement of ryanodine receptors for pacemaker Ca2+ activity in ICC and HEK293 cells J. Cell Sci., June 1, 2004; 117(13): 2813 - 2825. [Abstract] [Full Text] [PDF]
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R. A. Pulver, P. Rose-Curtis, M. W. Roe, G. C. Wellman, and K. M. Lounsbury Store-Operated Ca2+ Entry Activates the CREB Transcription Factor in Vascular Smooth Muscle Circ. Res., May 28, 2004; 94(10): 1351 - 1358. [Abstract] [Full Text] [PDF]
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J. Yao, Q. Li, J. Chen, and S. Muallem Subpopulation of Store-operated Ca2+ Channels Regulate Ca2+-induced Ca2+ Release in Non-excitable Cells J. Biol. Chem., May 14, 2004; 279(20): 21511 - 21519. [Abstract] [Full Text] [PDF]
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Z. Hong, A. Olschewski, H. L. Reeve, D. P. Nelson, F. Hong, and E. K. Weir Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L531 - L538. [Abstract] [Full Text] [PDF]
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S. P. Parsons and T. B. Bolton Localised calcium release events in cells from the muscle of guinea-pig gastric fundus J. Physiol., February 1, 2004; 554(3): 687 - 705. [Abstract] [Full Text] [PDF]
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K. Tsuzuki, H. Xing, J. Ling, and J. G. Gu Menthol-Induced Ca2+ Release from Presynaptic Ca2+ Stores Potentiates Sensory Synaptic Transmission J. Neurosci., January 21, 2004; 24(3): 762 - 771. [Abstract] [Full Text] [PDF]
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A. Shalabi, F. Zamudio, X. Wu, A. Scaloni, L. D. Possani, and M. L. Villereal Tetrapandins, a New Class of Scorpion Toxins That Specifically Inhibit Store-operated Calcium Entry in Human Embryonic Kidney-293 Cells J. Biol. Chem., January 9, 2004; 279(2): 1040 - 1049. [Abstract] [Full Text] [PDF]
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A. Miyakawa-Naito, P. Uhlen, M. Lal, O. Aizman, K. Mikoshiba, H. Brismar, S. Zelenin, and A. Aperia Cell Signaling Microdomain with Na,K-ATPase and Inositol 1,4,5-Trisphosphate Receptor Generates Calcium Oscillations J. Biol. Chem., December 12, 2003; 278(50): 50355 - 50361. [Abstract] [Full Text] [PDF]
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J. Yu, B. Leibiger, S.-N. Yang, J. J. Caffery, S. B. Shears, I. B. Leibiger, C. J. Barker, and P.-O. Berggren Cytosolic Multiple Inositol Polyphosphate Phosphatase in the Regulation of Cytoplasmic Free Ca2+ Concentration J. Biol. Chem., November 21, 2003; 278(47): 46210 - 46218. [Abstract] [Full Text] [PDF]
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N. Li, J.-Y. Sul, and P. G. Haydon A Calcium-Induced Calcium Influx Factor, Nitric Oxide, Modulates the Refilling of Calcium Stores in Astrocytes J. Neurosci., November 12, 2003; 23(32): 10302 - 10310. [Abstract] [Full Text] [PDF]
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T. D. Werry, G. F. Wilkinson, and G. B. Willars Cross Talk between P2Y2 Nucleotide Receptors and CXC Chemokine Receptor 2 Resulting in Enhanced Ca2+ Signaling Involves Enhancement of Phospholipase C Activity and Is Enabled by Incremental Ca2+ Release in Human Embryonic Kidney Cells J. Pharmacol. Exp. Ther., November 1, 2003; 307(2): 661 - 669. [Abstract] [Full Text] [PDF]
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