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RI): role in asthma
* Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada;
Centre de Recherche, CHUM, Notre Dame Hospital, Montreal, Quebec, Canada; and
Juntendo University Medical School, Tokyo, Japan
1Correspondence: Meakins-Christie Laboratories, McGill University, 3626 St. Urban Street, H2X2P2, Montreal, Quebec, Canada. E-mail: Abdel{at}meakins.lan.mcgill.ca
Polymorphonuclear neutrophils (PMNs) are important effector cells in
host defense and the inflammatory response to antigen. The involvement
of PMNs in inflammation is mediated mainly by the Fc receptor family,
including IgE receptors. Recently, PMNs were shown to express two IgE
receptors (CD23/Fc
RII and galectin-3). In allergic diseases, the
dominant role of IgE has been mainly ascribed to its high-affinity
receptor, FcRI. We have examined the expression of FcRI by PMNs.
mRNA and cell surface expression of FcRI
chain was identified on
PMNs from asthmatic subjects. Furthermore, preincubation with human IgE
Fc fragment blocks completely the binding of anti-FcRI chain
(mAb15–1) to human PMNs. Conversely, preincubation of PMNs with
mAb15–1 inhibits significantly the binding of IgE Fc fragment to PMNs,
indicating that IgE bound to the cell surface of PMNs mainly via the
FcRI. Peripheral blood and bronchoalveolar lavage (BAL) PMNs from
asthmatic subjects also express intracellular FcRI and ß chain
immunoreactivity. Engagement of FcRI induces the release of IL-8 by
PMNs. Collectively, these observations provide new evidence that PMNs
express the FcRI and suggest that these cells may play a role in
allergic inflammation through an IgE-dependent activation
mechanism.—Gounni, A. S., Lamkhioued, B., Koussih, L., Ra, C.,
Renzi, P. M, Hamid, Q. Human neutrophils express the high-affinity
receptor for immunoglobulin E (FcRI): role in asthma.
Key Words: allergic diseases • IgE receptors • interleukin 8
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