| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Unité INSERM U343 et Laboratoire d’Immunologie, 06202 Nice cedex 3, France;
* Diaclone research, BP1985, F25020 Besançon cedex, France;
§ Division of Infectious Diseases, Washington University School of Medecine, Saint Louis, Missouri, 63110, USA; and
University of California, San Francisco, San Francisco, California 94143, USA
1Correspondence: Unité INSERM U343, Hôpital de l’Archet 1, Route de St. Antoine de Ginestiere-BP 3079, 06202 Nice cedex 3, France. E-mail: u343{at}hermes.unice.fr
Integrin-associated protein (CD47/IAP) is a pentaspan molecule that
regulates integrin functions. We prepared a CD47-deficient Jurkat T
cell line to assess its role in the arrest of T cells on inflammatory
endothelium. Under flow conditions, constitutive arrest of
CD47-deficient cells is strongly decreased as compared to the original
cell line, whereas reexpression of CD47 reestablishes their ability to
stop. Moreover, cells transfected with a chimera made with the
extracellular portion of CD47 and the transmembrane domain of CD7 or
several truncated forms of CD47 show that the first transmembrane
domain and a short cytoplasmic loop are sufficient for this process.
CD47 effect is indirect and depends mainly on the 
4ß1/VCAM-1
pathway, as shown by blocking antibodies. We detected on endothelium
the two CD47 counter receptors known to date: thrombospondin and
SIRP1. Blocking experiments show that both are involved. Overall,
CD47 participates in the constitutive arrest of T lymphocytes on
inflamed vascular endothelium by up-regulating 4ß1
integrins.—Ticchioni, M., Raimondi, V., Lamy, L., Wijdenes, J.,
Lindberg, F. P., Brown, E. J., Bernard, A.
Integrin-associated protein (CD47/IAP) contributes to T cell arrest on
inflammatory vascular endothelium under flow.
Key Words: adhesion • T cell circulation • integrin
This article has been cited by other articles:
|
|
 |
|
  J. S. Isenberg, D. S. Annis, M. L. Pendrak, M. Ptaszynska, W. A. Frazier, D. F. Mosher, and D. D. Roberts Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses J. Biol. Chem., January 9, 2009; 284(2): 1116 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Stefanidakis, G. Newton, W. Y. Lee, C. A. Parkos, and F. W. Luscinskas Endothelial CD47 interaction with SIRP{gamma} is required for human T-cell transendothelial migration under shear flow conditions in vitro Blood, August 15, 2008; 112(4): 1280 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bouguermouh, V. Q. Van, J. Martel, P. Gautier, M. Rubio, and M. Sarfati CD47 Expression on T Cell Is a Self-Control Negative Regulator of Type 1 Immune Response J. Immunol., June 15, 2008; 180(12): 8073 - 8082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Isenberg, D. D. Roberts, and W. A. Frazier CD47: A New Target in Cardiovascular Therapy Arterioscler. Thromb. Vasc. Biol., April 1, 2008; 28(4): 615 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Rao, L. Yang, G. Garcia-Cardena, and F. W. Luscinskas Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall Circ. Res., August 3, 2007; 101(3): 234 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. de Leval, D. S. Rickman, C. Thielen, A. d. Reynies, Y.-L. Huang, G. Delsol, L. Lamant, K. Leroy, J. Briere, T. Molina, et al. The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells Blood, June 1, 2007; 109(11): 4952 - 4963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Li, Z. Liu, M. Uzunel, and K.-G. Sundqvist Endogenous thrombospondin-1 is a cell-surface ligand for regulation of integrin-dependent T-lymphocyte adhesion Blood, November 1, 2006; 108(9): 3112 - 3120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Manna, J. Dimitry, P.-A. Oldenborg, and W. A. Frazier CD47 Augments Fas/CD95-mediated Apoptosis J. Biol. Chem., August 19, 2005; 280(33): 29637 - 29644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Richter, R. Bistrian, S. Escher, W.-G. Forssmann, J. Vakili, R. Henschler, N. Spodsberg, A. Frimpong-Boateng, and U. Forssmann Quantum Proteolytic Activation of Chemokine CCL15 by Neutrophil Granulocytes Modulates Mononuclear Cell Adhesiveness J. Immunol., August 1, 2005; 175(3): 1599 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Rosenthal-Allieri, M. Ticchioni, J. P. Breittmayer, Y. Shimizu, and A. Bernard Influence of {beta}1 Integrin Intracytoplasmic Domains in the Regulation of VLA-4-Mediated Adhesion of Human T Cells to VCAM-1 under Flow Conditions J. Immunol., July 15, 2005; 175(2): 1214 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. V. Kolesnikova, C. S. Stipp, R. M. Rao, W. S. Lane, F. W. Luscinskas, and M. E. Hemler EWI-2 modulates lymphocyte integrin {alpha}4{beta}1 functions Blood, April 15, 2004; 103(8): 3013 - 3019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. T. Chen, E. J. Brown, E. J. Huang, and W. E. Seaman Expression and Activation of Signal Regulatory Protein {alpha} on Astrocytomas Cancer Res., January 1, 2004; 64(1): 117 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Feigelson, V. Grabovsky, R. Shamri, S. Levy, and R. Alon The CD81 Tetraspanin Facilitates Instantaneous Leukocyte VLA-4 Adhesion Strengthening to Vascular Cell Adhesion Molecule 1 (VCAM-1) under Shear Flow J. Biol. Chem., December 19, 2003; 278(51): 51203 - 51212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Vallejo, H. Yang, P. A. Klimiuk, C. M. Weyand, and J. J. Goronzy Synoviocyte-Mediated Expansion of Inflammatory T Cells in Rheumatoid Synovitis Is Dependent on CD47-Thrombospondin 1 Interaction J. Immunol., August 15, 2003; 171(4): 1732 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lamy, M. Ticchioni, A. K. Rouquette-Jazdanian, M. Samson, M. Deckert, A. H. Greenberg, and A. Bernard CD47 and the 19 kDa Interacting Protein-3 (BNIP3) in T Cell Apoptosis J. Biol. Chem., June 20, 2003; 278(26): 23915 - 23921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lagadec, O. Dejoux, M. Ticchioni, F. Cottrez, M. Johansen, E. J. Brown, and A. Bernard Involvement of a CD47-dependent pathway in platelet adhesion on inflamed vascular endothelium under flow Blood, June 15, 2003; 101(12): 4836 - 4843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. O. Barazi, Z. Li, J. A. Cashel, H. C. Krutzsch, D. S. Annis, D. F. Mosher, and D. D. Roberts Regulation of Integrin Function by CD47 Ligands. DIFFERENTIAL EFFECTS ON alpha vbeta 3 AND alpha 4beta 1 INTEGRIN-MEDIATED ADHESION J. Biol. Chem., November 1, 2002; 277(45): 42859 - 42866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamao, T. Noguchi, O. Takeuchi, U. Nishiyama, H. Morita, T. Hagiwara, H. Akahori, T. Kato, K. Inagaki, H. Okazawa, et al. Negative Regulation of Platelet Clearance and of the Macrophage Phagocytic Response by the Transmembrane Glycoprotein SHPS-1 J. Biol. Chem., October 11, 2002; 277(42): 39833 - 39839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. de Vries, J. J. A. Hendriks, H. Honing, C. R. de Lavalette, S. M. A. van der Pol, E. Hooijberg, C. D. Dijkstra, and T. K. van den Berg Signal-Regulatory Protein {alpha}-CD47 Interactions Are Required for the Transmigration of Monocytes Across Cerebral Endothelium J. Immunol., June 1, 2002; 168(11): 5832 - 5839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ticchioni, C. Charvet, N. Noraz, L. Lamy, M. Steinberg, A. Bernard, and M. Deckert Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration Blood, May 1, 2002; 99(9): 3111 - 3118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Li, M. J. Calzada, J. M. Sipes, J. A. Cashel, H. C. Krutzsch, D. S. Annis, D. F. Mosher, and D. D. Roberts Interactions of thrombospondins with {alpha}4{beta}1 integrin and CD47 differentially modulate T cell behavior J. Cell Biol., April 29, 2002; 157(3): 509 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yoshida, Y. Tomiyama, K. Oritani, Y. Murayama, J. Ishikawa, H. Kato, J.-i. Miyagawa, N. Honma, T. Nishiura, and Y. Matsuzawa Interaction Between Src Homology 2 Domain Bearing Protein Tyrosine Phosphatase Substrate-1 and CD47 Mediates the Adhesion of Human B Lymphocytes to Nonactivated Endothelial Cells J. Immunol., April 1, 2002; 168(7): 3213 - 3220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Li, M. J. Calzada, J. M. Sipes, J. A. Cashel, H. C. Krutzsch, D. S. Annis, D. F. Mosher, and D. D. Roberts Interactions of thrombospondins with {alpha}4{beta}1 integrin and CD47 differentially modulate T cell behavior J. Cell Biol., April 29, 2002; 157(3): 509 - 519. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
