| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Research Group Immunobiology, Medical Department of the Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf, Germany
1Correspondence: Research Group Immunobiology 23.12, MED-Heinrich-Heine-University of Düsseldorf, Moorenstr. 5, D-40225 Düsseldorf, Germany. E-mail: kroencke{at}uni-duesseldorf.de
Nitric oxide (NO) in the low nanomolar range acts as a transcellular messenger molecule to initiate regulatory and physiological responses in nearby target cells via binding to the soluble guanylate cyclase heme moiety. Higher NO concentrations, as synthesized by the inducible NO synthase (iNOS) during inflammatory processes, show additional effects: NO may react with O2, yielding nitrogen oxides like N2O3 that are able to nitrosate thiols. A variety of proteins involved in very different functions of the cell contain cysteine–Zn2+ complexes. Effects of NO on different proteins containing cysteine–Zn2+ domains and playing essential roles during transcription, protein folding, and proteolysis are discussed. It is suggested that iNOS-derived NO acts as a signal molecule targeting cysteine–Zn2+ linkages, thus enabling cells to react toward nitrosative stress.—Kröncke, K.-D. Cysteine–Zn2+ complexes: unique molecular switches for inducible nitric oxide synthase-derived NO.
Key Words: chaperone • cysteine switch • metalloproteinase • nitric oxide • transcription • zinc
This article has been cited by other articles:
|
|
 |
|
  L. A. Ridnour, A. N. Windhausen, J. S. Isenberg, N. Yeung, D. D. Thomas, M. P. Vitek, D. D. Roberts, and D. A. Wink Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways PNAS, October 23, 2007; 104(43): 16898 - 16903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Jang, H. Wang, J. Xi, R. A. Mueller, E. A. Norfleet, and Z. Xu NO mobilizes intracellular Zn2+ via cGMP/PKG signaling pathway and prevents mitochondrial oxidant damage in cardiomyocytes Cardiovasc Res, July 15, 2007; 75(2): 426 - 433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Olcott, G. Tocco, J. Tian, D. Zekzer, J. Fukuto, L. Ignarro, and D. L. Kaufman A Salen-Manganese Catalytic Free Radical Scavenger Inhibits Type 1 Diabetes and Islet Allograft Rejection Diabetes, October 1, 2004; 53(10): 2574 - 2580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Jeong, K. Y. Lee, D. Shin, H. Chung, S. H. Jeon, and R. H. Seong Nitric Oxide Inhibits Glucocorticoid-induced Apoptosis of Thymocytes by Repressing the SRG3 Expression J. Biol. Chem., August 13, 2004; 279(33): 34373 - 34379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. U. Spahl, D. Berendji-Grun, C. V. Suschek, V. Kolb-Bachofen, and K.-D. Kroncke Regulation of zinc homeostasis by inducible NO synthase-derived NO: Nuclear metallothionein translocation and intranuclear Zn2+ release PNAS, November 25, 2003; 100(24): 13952 - 13957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Howard, H. Fischer, J. Roux, B. C. Santos, S. R. Gullans, P. H. Yancey, and W. J. Welch Mammalian Osmolytes and S-Nitrosoglutathione Promote {Delta}F508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein Maturation and Function J. Biol. Chem., September 12, 2003; 278(37): 35159 - 35167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-D. Kroncke, L.-O. Klotz, C. V. Suschek, and H. Sies Comparing Nitrosative Versus Oxidative Stress toward Zinc Finger-dependent Transcription. UNIQUE ROLE FOR NO J. Biol. Chem., April 5, 2002; 277(15): 13294 - 13301. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
