FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BOTCHKAREV, V. A.
Right arrow Articles by GILCHREST, B. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BOTCHKAREV, V. A.
Right arrow Articles by GILCHREST, B. A.
(The FASEB Journal. 2001;15:2205-2214.)
© 2001 FASEB

Noggin is required for induction of the hair follicle growth phase in postnatal skin

VLADIMIR A. BOTCHKAREV1, NATALIA V. BOTCHKAREVA, MOTONOBU NAKAMURA*, OTMAR HUBER{dagger}, KEIKO FUNA{ddagger}, ROLAND LAUSTER§, RALF PAUS* and BARBARA A. GILCHREST

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA;
* Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg, Germany;
{dagger} Department of Clinical Chemistry and Pathobiochemistry, University Hospital Benjamin Franklin, Free University, Berlin, Germany;
{ddagger} Department of Anatomy and Cell Biology, University of Goteborg, Goteborg, Sweden; and
§ Deutsches Rheumaforschungzentrum, Berlin, Germany

1Correspondence: Department of Dermatology, Boston University School of Medicine, 609 Albany St., Boston, MA 02118, USA. E-mail: vladbotc{at}bu.edu

During postnatal development, the hair follicle (HF) shows cyclic activity with periods of relative resting, active growth (anagen), and regression. We demonstrate that similar to the HF induction in embryonic skin, initiation of a new hair growth phase in postnatal skin requires neutralization of the inhibitory activity of bone morphogenetic protein 4 (BMP4) by the BMP antagonist noggin. In the resting HF, BMP4 mRNA predominates over noggin in the epithelium and mesenchyme, and the BMP receptor IA is prominently expressed in the follicular germ. Anagen development is accompanied by down-regulation of the BMP4 and increased noggin mRNA in the HF. Furthermore, administration of noggin protein induces new hair growth phase in postnatal telogen skin in vivo. In contrast, BMP4 induces selective arrest of anagen development in the non-tylotrich (secondary) HF. As a hair growth inducer, noggin increases Shh mRNA in the HF whereas BMP4 down-regulates Shh. This suggests that modulation of BMP4 signaling by noggin is essential for hair growth phase induction in postnatal skin and that the hair growth-inducing effect of noggin is mediated, at least in part, by Shh.—Botchkarev, V. A., Botchkareva, N. V., Nakamura, M., Huber, O., Funa, K., Lauster, R., Paus, R., Gilchrest, B. A. Noggin is required for induction of the hair follicle growth phase in postnatal skin.


Key Words: hair cycle • bone morphogenetic protein • telogen • anagen • sonic hedgehog




This article has been cited by other articles:


Home page
 Genes Dev.Home page
J. Gao, M. C. DeRouen, C.-H. Chen, M. Nguyen, N. T. Nguyen, H. Ido, K. Harada, K. Sekiguchi, B. A. Morgan, J. H. Miner, et al.
Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
Genes & Dev., August 1, 2008; 22(15): 2111 - 2124.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
B. D. Yu, A. Mukhopadhyay, and C. Wong
Skin and hair: models for exploring organ regeneration
Hum. Mol. Genet., April 15, 2008; 17(R1): R54 - R59.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Y. Fessing, T. Y. Sharova, A. A. Sharov, R. Atoyan, and V. A. Botchkarev
Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)
Am. J. Pathol., December 1, 2006; 169(6): 2075 - 2084.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
J. Zhang, X. C. He, W.-G. Tong, T. Johnson, L. M. Wiedemann, Y. Mishina, J. Q. Feng, and L. Li
Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion
Stem Cells, December 1, 2006; 24(12): 2826 - 2839.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. A. Sharov, T. Y. Sharova, A. N. Mardaryev, A. T. di Vignano, R. Atoyan, L. Weiner, S. Yang, J. L. Brissette, G. P. Dotto, and V. A. Botchkarev
Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes
PNAS, November 28, 2006; 103(48): 18166 - 18171.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
U. Ohnemus, M. Uenalan, J. Inzunza, J.-A. Gustafsson, and R. Paus
The Hair Follicle as an Estrogen Target and Source
Endocr. Rev., October 1, 2006; 27(6): 677 - 706.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Yang, C. Mao, Y. Teng, W. Li, J. Zhang, X. Cheng, X. Li, X. Han, Z. Xia, H. Deng, et al.
Targeted Disruption of Smad4 in Mouse Epidermis Results in Failure of Hair Follicle Cycling and Formation of Skin Tumors
Cancer Res., October 1, 2005; 65(19): 8671 - 8678.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. A. Sharov, M. Fessing, R. Atoyan, T. Y. Sharova, C. Haskell-Luevano, L. Weiner, K. Funa, J. L. Brissette, B. A. Gilchrest, and V. A. Botchkarev
Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway
PNAS, January 4, 2005; 102(1): 93 - 98.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Andl, K. Ahn, A. Kairo, E. Y. Chu, L. Wine-Lee, S. T. Reddy, N. J. Croft, J. A. Cebra-Thomas, D. Metzger, P. Chambon, et al.
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development
Development, May 15, 2004; 131(10): 2257 - 2268.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Yuhki, M. Yamada, M. Kawano, T. Iwasato, S. Itohara, H. Yoshida, M. Ogawa, and Y. Mishina
BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice
Development, April 15, 2004; 131(8): 1825 - 1833.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-C. Hsieh, J. M. Sisk, P. W. Jurutka, C. A. Haussler, S. A. Slater, M. R. Haussler, and C. C. Thompson
Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling
J. Biol. Chem., October 3, 2003; 278(40): 38665 - 38674.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Ruiz, C. Segrelles, A. Bravo, M. Santos, P. Perez, H. Leis, J. L. Jorcano, and J. M. Paramio
Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130
Development, June 1, 2003; 130(11): 2341 - 2353.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. A. Podlasek, D. J. Zelner, H. B. Jiang, Y. Tang, J. Houston, K. E. McKenna, and K. T. McVary
Sonic hedgehog Cascade Is Required for Penile Postnatal Morphogenesis, Differentiation, and Adult Homeostasis
Biol Reprod, February 1, 2003; 68(2): 423 - 438.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by The Federation of American Societies for Experimental Biology.