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(The FASEB Journal. 2001;15:1694-1703.)
© 2001 FASEB

A view through the clouds of imprinting

JASON L. BURNS*, DEAN A. JACKSON{dagger} and A. BASSIM HASSAN*1

* Department of Zoology, University of Oxford, Oxford, UK OX1 3PS; and
{dagger} Department of Biomolecular Sciences, University of Manchester Institute for Science and Technology, Manchester, UK M60 1QD

1Correspondence: Department of Zoology, University of Oxford, South Parks Road, Oxford, UK. OX1 3PS. U.K. E-mail: bass.hassan{at}zoo.ox.ac.uk

The purpose of this review is to examine whether our current knowledge of the higher order control of gene expression and nuclear organization can help us understand the mechanisms of genomic imprinting. Imprinting involves the inheritance of a silenced allele of a gene through either a paternal or maternal germline. We have approached the problem of imprinting using a model based on the dynamic attachment of chromatin loops to immobilized RNA polymerases and control elements. We have combined the information from different experimental approaches, examining primarily the IGF2-H19 locus, in an attempt to simplify the complexity of the imprinting data that has accumulated. It is hoped that a unified model may generate predictions amenable to experimental testing and contribute to the interpretation of future experiments.—Burns, J. L., Jackson, D. A., Hassan, A. B. A view through the clouds of imprinting.


Key Words: transcription cycles • transcription factories • insulin-like growth factor II • chromatin • boundary




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