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Co-localization of TFF3 peptide and oxytocin in the human hypothalamus

WOLFGANG JAGLA^*, ANTJE WIEDE^*, KNUT DIETZMANN, KAREN RUTKOWSKI^* and WERNER HOFFMANN^*1

^* Institut für Molekularbiologie und Medizinische Chemie, Otto-von-Guericke-Universität, D-39120 Magdeburg, Germany; and
Institut für Neuropathologie, Otto-von-Guericke-Universität, D-39120 Magdeburg, Germany

¹Correspondence: Institut für Molekularbiologie und Medizinische Chemie, Universitätsklinikum, Leipziger Str. 44, D-39120 Magdeburg, Germany. E-mail: Werner.Hoffmann{at}Medizin.Uni-Magdeburg.de

TFF-peptides (formerly P domain peptides, trefoil factors) are typical secretory products of many mucous epithelial cells. TFF3 is also synthesized in the hypothalamus and has anxiolytic or anxiogenic activities when injected into the rat amygdala. Here we show by immunohistochemistry that TFF3 is localized to a distinct population of neurons of the human hypothalamic paraventricular and supraoptic nuclei. Generally, TFF3-positive cells are co-localized in oxytocin-producing cells and not in vasopressin-producing cells. Relatively large amounts of TFF3—but not TFF1 and TFF2—are present in the posterior lobe of the human pituitary, where it is probably released into the bloodstream. Furthermore, TFF3 was also detectable in human postmortem cerebrospinal fluid.—Jagla, W., Wiede, A., Dietzmann, K., Rutkowski, K., Hoffmann, W. Co-localization of TFF3 peptide and oxytocin in the human hypothalamus.

Key Words: pituitary • TFF-domain • neuropeptide • oxytocin • vasopressin • epithelial cell migration • anxiolytic

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