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Division of Surgical Research, Children’s Hospital, Boston, Massachusetts 02115, USA; and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02115, USA
1Correspondence: Children’s Hospital, Enders 1006, 300 Longwood Ave., Boston, MA 02115, USA. E-mail: damato_r{at}a1.tch.harvard.edu
Many diseases, including cancer, are dependent on the growth of new blood vessels, a process known as angiogenesis. Differences in an individual’s ability to grow new blood vessels may influence the rate of progression of these diseases. Here we show that different strains of inbred mice have an ~10-fold range of response to growth factor-stimulated angiogenesis in the corneal micropocket assay. The in vitro migratory activity of endothelial cells from aortic rings of selected strains correlated with the in vivo responsiveness. Further, a differential sensitivity to angiogenesis inhibitors was seen between strains, with one strain demonstrating resistance to both TNP-470 and thalidomide. These results suggest the presence of genetic factors that control individual angiogenic potential.—Rohan, R. M., Fernandez, A., Udagawa, T., Yuan, J., D’Amato, R. J. Genetic heterogeneity of angiogenesis in mice.
Key Words: growth factors • blood vessels • endothelial cells • inbred strains
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