| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Institute of Molecular Animal Breeding, Gene Center, D-81377 Munich, Germany
1Correspondence: Institute of Molecular Animal Breeding, Gene Center, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany. E-mail: ewolf{at}lmb.uni-muenchen.de
The insulin-like growth factor-binding proteins (IGFBPs) comprise a family of six related peptides that interact with high affinity with IGFs. IGFBPs compete with IGF receptors for IGF binding, and as a consequence of this competition they can affect cell growth. In addition, IGF-independent regulatory mechanisms of IGFBPs have been described. Despite their common property to interact with IGFs every IGFBP is expressed in a tightly regulated time- and tissue-specific manner suggesting that each protein may have its own distinct functions. Several transgenic mouse models overexpressing IGFBP-1, -2, -3, or -4 were developed in the past few years. Brain abnormalities were a common feature of IGFBP-1 transgenic models. Individual strains showed alterations in glucose homeostasis, reproductive performance, and a reduction of somatic growth as the most prominent phenotypes. The latter was also the main effect observed in IGFBP-2 transgenic mice. The overexpression of IGFBP-3 under the control of an ubiquitous promoter resulted in selective organomegaly, whereas mammary gland-targeted expression of this protein caused an altered involution after pregnancy in this organ. Tissue-specific overexpression of IGFBP-4 resulted in hypoplasia and reduced weight of smooth muscle-rich tissues such as bladder, aorta, and stomach. This review summarizes the current knowledge about the actions of IGFBPs in vivo based on the presently established transgenic mice.—Schneider, M. R., Lahm, H., Wu, M., Hoeflich, A., Wolf, E. Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins.
Key Words: IGFBP • insulin-like growth factors • transgenic mice • overexpression • knockout
This article has been cited by other articles:
|
|
 |
|
  A. M. Arafat, M. O. Weickert, J. Frystyk, J. Spranger, C. Schofl, M. Mohlig, and A. F. H. Pfeiffer The Role of Insulin-Like Growth Factor (IGF) Binding Protein-2 in the Insulin-Mediated Decrease in IGF-I Bioactivity J. Clin. Endocrinol. Metab., December 1, 2009; 94(12): 5093 - 5101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Escribano, C. Guillen, C. Nevado, A. Gomez-Hernandez, C. R. Kahn, and M. Benito {beta}-Cell Hyperplasia Induced by Hepatic Insulin Resistance: Role of a Liver-Pancreas Endocrine Axis Through Insulin Receptor A Isoform Diabetes, April 1, 2009; 58(4): 820 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yakar, C. J. Rosen, M. L. Bouxsein, H. Sun, W. Mejia, Y. Kawashima, Y. Wu, K. Emerton, V. Williams, K. Jepsen, et al. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism FASEB J, March 1, 2009; 23(3): 709 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Lewis, M. Fournier, T. W. Storer, S. Bhasin, J. Porszasz, S.-G. Ren, X. Da, and R. Casaburi Skeletal muscle adaptations to testosterone and resistance training in men with COPD J Appl Physiol, October 1, 2007; 103(4): 1299 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Saenger, P. Czernichow, I. Hughes, and E. O. Reiter Small for Gestational Age: Short Stature and Beyond Endocr. Rev., April 1, 2007; 28(2): 219 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ning, A. G. P. Schuller, S. Bradshaw, P. Rotwein, T. Ludwig, J. Frystyk, and J. E. Pintar Diminished Growth and Enhanced Glucose Metabolism in Triple Knockout Mice Containing Mutations of Insulin-Like Growth Factor Binding Protein-3, -4, and -5 Mol. Endocrinol., September 1, 2006; 20(9): 2173 - 2186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Shukla, X. Coumoul, L. Cao, R.-H. Wang, C. Xiao, X. Xu, S. Ando, S. Yakar, D. LeRoith, and C. Deng Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members. Cancer Res., July 15, 2006; 66(14): 7151 - 7157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Christians, A. Hoeflich, and P. D. Keightley PAPPA2, an Enzyme That Cleaves an Insulin-Like Growth-Factor-Binding Protein, Is a Candidate Gene for a Quantitative Trait Locus Affecting Body Size in Mice Genetics, July 1, 2006; 173(3): 1547 - 1553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Hu, Z. Zhang, J. W. Kim, Y. Huang, and T. J. Liang Altered Proteolysis and Global Gene Expression in Hepatitis B Virus X Transgenic Mouse Liver J. Virol., February 1, 2006; 80(3): 1405 - 1413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Mantey, G. A. Brockmann, E. Kalm, and N. Reinsch Mapping and Exclusion Mapping of Genomic Imprinting Effects in Mouse F2 Families J. Hered., July 1, 2005; 96(4): 329 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, A. D. Rogol, J. C. Lovejoy, M. Sheffield-Moore, N. Mauras, and C. Y. Bowers Endocrine Control of Body Composition in Infancy, Childhood, and Puberty Endocr. Rev., February 1, 2005; 26(1): 114 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Marchand, C. Tomkiewicz, J.-P. Marchandeau, E. Boitier, R. Barouki, and M. Garlatti 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Insulin-Like Growth Factor Binding Protein-1 Gene Expression and Counteracts the Negative Effect of Insulin Mol. Pharmacol., February 1, 2005; 67(2): 444 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Chandrashekar, D. Zaczek, and A. Bartke The Consequences of Altered Somatotropic System on Reproduction Biol Reprod, July 1, 2004; 71(1): 17 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bienvenu, D. Seurin, P. Grellier, P. Froment, M. Baudrimont, P. Monget, Y. Le Bouc, and S. Babajko Insulin-Like Growth Factor Binding Protein-6 Transgenic Mice: Postnatal Growth, Brain Development, and Reproduction Abnormalities Endocrinology, May 1, 2004; 145(5): 2412 - 2420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Froment, C. Staub, S. Hembert, C. Pisselet, M. Magistrini, B. Delaleu, D. Seurin, J. E. Levine, L. Johnson, M. Binoux, et al. Reproductive Abnormalities in Human Insulin-Like Growth Factor-Binding Protein-1 Transgenic Male Mice Endocrinology, April 1, 2004; 145(4): 2080 - 2091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Delafontaine, Y.-H. Song, and Y. Li Expression, Regulation, and Function of IGF-1, IGF-1R, and IGF-1 Binding Proteins in Blood Vessels Arterioscler Thromb Vasc Biol, March 1, 2004; 24(3): 435 - 444. [Abstract] [Full Text]
|
|
|
|
 |
|
 J A Mohammed, A Y. Mok, A Parbtani, and D G Matsell Increased expression of insulin-like growth factors in progressive glomerulonephritis of the MRL lpr mouse Lupus, August 1, 2003; 12(8): 584 - 590. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Conti, D. Pitocco, E. Capoluongo, C. Zuppi, G. Ghirlanda, F. Crea, and F. Andreotti IGF-1 and Macrovascular Complications of Diabetes: Alternative interpretations of recently published data Diabetes Care, May 1, 2003; 26(5): 1653 - 1654. [Full Text] [PDF]
|
|
|
|
 |
|
 I. Foucher, M. Volovitch, M. Frain, J. J. Kim, J.-C. Souberbielle, L. Gan, T. G. Unterman, A. Prochiantz, and A. Trembleau Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors Development, September 1, 2002; 129(17): 4065 - 4074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Sandhu, D. B. Dunger, and E. L. Giovannucci Insulin, Insulin-Like Growth Factor-I (IGF-I), IGF Binding Proteins, Their Biologic Interactions, and Colorectal Cancer J Natl Cancer Inst, July 3, 2002; 94(13): 972 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Froment, D. Seurin, S. Hembert, J. E. Levine, C. Pisselet, D. Monniaux, M. Binoux, and P. Monget Reproductive Abnormalities in Human IGF Binding Protein-1 Transgenic Female Mice Endocrinology, May 1, 2002; 143(5): 1801 - 1808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hoeflich, R. Reisinger, H. Lahm, W. Kiess, W. F. Blum, H. J. Kolb, M. M. Weber, and E. Wolf Insulin-like Growth Factor-binding Protein 2 in Tumorigenesis: Protector or Promoter? Cancer Res., December 1, 2001; 61(24): 8601 - 8610. [Full Text] [PDF]
|
|
|
|
|
|
E. P. Smith, A. Kamyar, W. Niu, J. Wang, B. Cercek, S. D. Chernausek, and J. A. Fagin IGF-Binding Protein-4 Expression and IGF-Binding Protein-4 Protease Activity Are Regulated Coordinately in Smooth Muscle During Postnatal Development and After Vascular Injury Endocrinology, October 1, 2001; 142(10): 4420 - 4427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Jervis and B. Robaire Dynamic Changes in Gene Expression along the Rat Epididymis Biol Reprod, September 1, 2001; 65(3): 696 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Fu, T. Noguchi, and H. Kato Differential regulation of IGFBP-2 and IGFBP-5 gene expression by vitamin A status in Japanese quail Am J Physiol Endocrinol Metab, July 1, 2001; 281(1): E138 - E146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hoeflich, S. Nedbal, W. F. Blum, M. Erhard, H. Lahm, G. Brem, H. J. Kolb, R. Wanke, and E. Wolf Growth Inhibition in Giant Growth Hormone Transgenic Mice by Overexpression of Insulin-Like Growth Factor-Binding Protein-2 Endocrinology, May 1, 2001; 142(5): 1889 - 1898. [Abstract] [Full Text]
|
|
|
|
|
|
K. Prelle, M. Stojkovic, K. Boxhammer, J. Motlik, D. Ewald, G. J. Arnold, and E. Wolf Insulin-Like Growth Factor I (IGF-I) and Long R3IGF-I Differently Affect Development and Messenger Ribonucleic Acid Abundance for IGF-Binding Proteins and Type I IGF Receptors in in Vitro Produced Bovine Embryos Endocrinology, March 1, 2001; 142(3): 1309 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Chan and R. W.-C. Wong Expression of Epidermal Growth Factor in Transgenic Mice Causes Growth Retardation J. Biol. Chem., December 1, 2000; 275(49): 38693 - 38698. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
