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differs in the expression of zinc-
2-glycoprotein and cathepsin D
,1
,§,12
* Departments of Dermatology,
Microbiology and Immunology,
Pathology, and
§ Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA; and
** Basic Research Laboratory, Kanebo Ltd., Odawara, Kanagawa, 250-0002 Japan
2Correspondence: Department of Dermatology, University of Texas Medical Branch, Galveston, Texas 77555-0783, USA. E-mail: mibrysk{at}utmb.edu
Psoriasis is a T cell-mediated inflammatory disease characterized by
hyperproliferation and by aberrant differentiation. We found cathepsin
D and zinc-
2-glycoprotein, two catalytic enzymes
associated with apoptosis and desquamation, to be present in the
stratum corneum of the normal epidermis but absent from the psoriatic
plaque. Psoriasis is characterized by an altered response to
interferon-
(IFN-), including the induction of apoptosis in
normal but not in psoriatic keratinocytes, often with opposite effects
on gene expression of suprabasal proteins. We found that IFN-
binding and signaling were attenuated in psoriasis: The IFN-
receptor, the signal transducer and activator of transcription STAT-1,
and the interferon regulatory factor IRF-1 were strongly up-regulated
by IFN- in normal keratinocytes, but not in psoriatic ones. IFN-
strongly up-regulated the expression of the catalytic enzymes cathepsin
D and zinc-2-glycoprotein in normal keratinocytes but
down-regulated them in psoriatic ones; the reverse was true of the
apoptotic suppressor bcl-2. We believe that the aberrant response to
IFN- plays a central role in the pathophysiology of psoriasis,
particularly the disruption of apoptosis and desquamation.—Chen,
S.-H., Arany, I., Apisarnthanarax, N., Rajaraman, S., Tyring,
S. K., Horikoshi, T., Brysk, H., Brysk, M. M. Response
of keratinocytes from normal and psoriatic epidermis to interferon-
differs in the expression of zinc-2-glycoprotein and
cathepsin D.
Key Words: interferon- receptors • interferon regulatory factor • interferon signal transducer and activator • epidermal differentiation • apoptosis • bcl-2.
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