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Molecular analysis of vesicular amine transporter function and targeting to secretory organelles

Neuroscience Center and Department of Pharmacology, Louisiania State University Health Sciences Center, New Orleans, Louisiana 70112, USA

¹Correspondence: LSUHSC/Neuroscience, 2020 Gravier St., Suite D, New Orleans, LA 70112, USA. E-mail: jerick{at}lsumc.edu

Vesicular transporters are responsible for the loading of neurotransmitters into specialized secretory organelles in neurons and neuroendocrine cells to make them available for regulated neurosecretion. The exocytotic release of neurotransmitter therefore depends on the functional activity of the vesicular transporters and their efficient sorting to these secretory organelles. Molecular analysis of vesicular transport proteins has revealed important information regarding structural domains responsible for their functional properties, including substrate specificity and trafficking to various classes of secretory vesicles. These studies have established the existence of an important functional relationship between transporter activity and presynaptic quantal neurosecretion.—Erickson, J. D., Varoqui, H. Molecular analysis of vesicular amine transporter function and targeting to secretory organelles.

Key Words: CAD • PC12 • biogenic amines • acetylcholine • small synaptic vesicle • large dense core vesicle • synaptic-like microvesicle • trafficking • quantal release

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