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* Biochip Technology Center, Argonne National Laboratory, Argonne, Illinois 60439-4833, USA;
Department of Cellular Biotechnologies and Hematology, University of Rome ‘La Sapienza’, 00161, Rome, Italy; and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331-7305, USA
1Correspondence: Biochip Technology Center, Argonne National Laboratory, 9700 S. Cass Ave., Bldg. 202-A253, Argonne, IL 60439-4833, USA. E-mail: zlatanoj{at}everest.bim.anl.gov
In recent years, the connection between chromatin structure and its transcriptional activity has attracted considerable experimental effort. The post-translational modifications to both the core histones and the linker histones are finely tuned through interactions with transcriptional regulators and change chromatin structure in a way to allow transcription to occur. Here we review evidence for the involvement of linker histones in transcriptional regulation and suggest a scenario in which the reversible and controllable binding/displacement of proteins of this class to the nucleosome entry/exit point determine the accessibility of the nucleosomal DNA to the transcriptional machinery.—Zlatanova, J., Caiafa, P., van Holde, K. Linker histone binding and displacement: versatile mechanism for transcriptional regulation.
Key Words: DNA methylation • linker histone modifications • nucleosomal DNA • transcription regulation
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