| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Biochip Technology Center, Argonne National Laboratory, Argonne, Illinois 60439-4833, USA;
Department of Cellular Biotechnologies and Hematology, University of Rome ‘La Sapienza’, 00161, Rome, Italy; and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331-7305, USA
1Correspondence: Biochip Technology Center, Argonne National Laboratory, 9700 S. Cass Ave., Bldg. 202-A253, Argonne, IL 60439-4833, USA. E-mail: zlatanoj{at}everest.bim.anl.gov
In recent years, the connection between chromatin structure and its transcriptional activity has attracted considerable experimental effort. The post-translational modifications to both the core histones and the linker histones are finely tuned through interactions with transcriptional regulators and change chromatin structure in a way to allow transcription to occur. Here we review evidence for the involvement of linker histones in transcriptional regulation and suggest a scenario in which the reversible and controllable binding/displacement of proteins of this class to the nucleosome entry/exit point determine the accessibility of the nucleosomal DNA to the transcriptional machinery.—Zlatanova, J., Caiafa, P., van Holde, K. Linker histone binding and displacement: versatile mechanism for transcriptional regulation.
Key Words: DNA methylation • linker histone modifications • nucleosomal DNA • transcription regulation
This article has been cited by other articles:
|
|
 |
|
  G. I. Belova, Y. V. Postnikov, T. Furusawa, Y. Birger, and M. Bustin Chromosomal Protein HMGN1 Enhances the Heat Shock-induced Remodeling of Hsp70 Chromatin J. Biol. Chem., March 28, 2008; 283(13): 8080 - 8088. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Weintraub and B. E. Deverman Chronoregulation by Asparagine Deamidation Sci. Signal., October 23, 2007; 2007(409): re7 - re7. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Roque, I. Ponte, and P. Suau Macromolecular Crowding Induces a Molten Globule State in the C-Terminal Domain of Histone H1 Biophys. J., September 15, 2007; 93(6): 2170 - 2177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Song and M. A. Gorovsky Unphosphorylated H1 Is Enriched in a Specific Region of the Promoter when CDC2 Is Down-Regulated during Starvation Mol. Cell. Biol., March 1, 2007; 27(5): 1925 - 1933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Wisniewski, A. Zougman, S. Kruger, and M. Mann Mass Spectrometric Mapping of Linker Histone H1 Variants Reveals Multiple Acetylations, Methylations, and Phosphorylation as Well as Differences between Cell Culture and Tissue Mol. Cell. Proteomics, January 1, 2007; 6(1): 72 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Launholt, T. Merkle, A. Houben, A. Schulz, and K. D. Grasser Arabidopsis Chromatin-Associated HMGA and HMGB Use Different Nuclear Targeting Signals and Display Highly Dynamic Localization within the Nucleus PLANT CELL, November 1, 2006; 18(11): 2904 - 2918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bhattacharya, A. Mazumder, S. A. Miriam, and G. V. Shivashankar EGFP-Tagged Core and Linker Histones Diffuse via Distinct Mechanisms within Living Cells Biophys. J., September 15, 2006; 91(6): 2326 - 2336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Garcia, S. Joshi, C. E. Thomas, R. K. Chitta, R. L. Diaz, S. A. Busby, P. C. Andrews, R. R. Ogorzalek Loo, J. Shabanowitz, N. L. Kelleher, et al. Comprehensive Phosphoprotein Analysis of Linker Histone H1 from Tetrahymena thermophila Mol. Cell. Proteomics, September 1, 2006; 5(9): 1593 - 1609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rybouchkin, Y. Kato, and Y. Tsunoda Role of Histone Acetylation in Reprogramming of Somatic Nuclei Following Nuclear Transfer Biol Reprod, June 1, 2006; 74(6): 1083 - 1089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. van Holde and J. Zlatanova Scanning Chromatin: a New Paradigm? J. Biol. Chem., May 5, 2006; 281(18): 12197 - 12200. [Full Text] [PDF]
|
|
|
|
|
|
J. F. Kepert, J. Mazurkiewicz, G. L. Heuvelman, K. F. Toth, and K. Rippe NAP1 Modulates Binding of Linker Histone H1 to Chromatin and Induces an Extended Chromatin Fiber Conformation J. Biol. Chem., October 7, 2005; 280(40): 34063 - 34072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Martic, Z. Karetsou, K. Kefala, A. S. Politou, C. R. Clapier, T. Straub, and T. Papamarcaki Parathymosin Affects the Binding of Linker Histone H1 to Nucleosomes and Remodels Chromatin Structure J. Biol. Chem., April 22, 2005; 280(16): 16143 - 16150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Kysela, M. Chovanec, and P. A. Jeggo Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1 PNAS, February 8, 2005; 102(6): 1877 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Adcock, K. Ito, and P. J. Barnes Glucocorticoids: Effects on Gene Transcription Proceedings of the ATS, November 1, 2004; 1(3): 247 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Rapizzi, S. Fossati, F. Moroni, and A. Chiarugi Inhibition of Poly(ADP-Ribose) Glycohydrolase by Gallotannin Selectively Up-Regulates Expression of Proinflammatory Genes Mol. Pharmacol., October 1, 2004; 66(4): 890 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Nair, S. K. Mishra, Z. Yang, S. Balasenthil, R. Kumar, and R. K. Vadlamudi Potential Role of a Novel Transcriptional Coactivator PELP1 in Histone H1 Displacement in Cancer Cells Cancer Res., September 15, 2004; 64(18): 6416 - 6423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. F. Toth, T. A. Knoch, M. Wachsmuth, M. Frank-Stohr, M. Stohr, C. P. Bacher, G. Muller, and K. Rippe Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin J. Cell Sci., August 15, 2004; 117(18): 4277 - 4287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rouleau, R. A. Aubin, and G. G. Poirier Poly(ADP-ribosyl)ated chromatin domains: access granted J. Cell Sci., February 22, 2004; 117(6): 815 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ramachandran, M. Omar, P. Cheslock, and G. R. Schnitzler Linker Histone H1 Modulates Nucleosome Remodeling by Human SWI/SNF J. Biol. Chem., December 5, 2003; 278(49): 48590 - 48601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Kepert, K. F. Toth, M. Caudron, N. Mucke, J. Langowski, and K. Rippe Conformation of Reconstituted Mononucleosomes and Effect of Linker Histone H1 Binding Studied by Scanning Force Microscopy Biophys. J., December 1, 2003; 85(6): 4012 - 4022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Fu, P. Ghadam, A. Sirotkin, S. Khochbin, A. I. Skoultchi, and H. J. Clarke Mouse Oocytes and Early Embryos Express Multiple Histone H1 Subtypes Biol Reprod, May 1, 2003; 68(5): 1569 - 1576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Koutzamani, H. Loborg, B. Sarg, H. H. Lindner, and I. Rundquist Linker Histone Subtype Composition and Affinity for Chromatin in Situ in Nucleated Mature Erythrocytes J. Biol. Chem., November 15, 2002; 277(47): 44688 - 44694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cheung, A. S. Zarifyan, and W. L. Kraus Histone H1 Represses Estrogen Receptor {alpha} Transcriptional Activity by Selectively Inhibiting Receptor-Mediated Transcription Initiation Mol. Cell. Biol., April 15, 2002; 22(8): 2463 - 2471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Schrem, J. Klempnauer, and J. Borlak Liver-Enriched Transcription Factors in Liver Function and Development. Part I: The Hepatocyte Nuclear Factor Network and Liver-Specific Gene Expression Pharmacol. Rev., March 1, 2002; 54(1): 129 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Banks, L. J. Deterding, K. B. Tomer, and T. K. Archer Hormone-mediated Dephosphorylation of Specific Histone H1 Isoforms J. Biol. Chem., September 21, 2001; 276(39): 36467 - 36473. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
