| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
2Correspondence: Department of Dermatology, Boston University School of Medicine, 609 Albany St., Boston, MA 02118, USA. E-mail: bgilchre{at}bu.edu
Skin cancer incidence is clearly linked to UV irradiation and increases exponentially with age. We studied the rate of removal of thymine dimers and (6–4) photoproducts in UV-irradiated human dermal fibroblasts derived from donors of different ages. There was a significant decrease with aging in the repair rates of both thymine dimers and (6–4) photoproducts (P<0.001). In addition, there was an age-associated decrease in the protein levels of ERCC3, PCNA, RPA, XPA, and p53 that participate in nucleotide excision repair. Moreover, the mRNA levels of XPA, ERCC3, and PCNA were significantly reduced with aging, suggesting that these decreases are often regulated at the mRNA level. Furthermore, with age induction of p53 after UV irradiation was significantly reduced. Taken together, our data suggest that the age-associated decrease in the repair of UV-induced DNA damage results at least in part from decreased levels of proteins that participate in the repair process.—Goukassian, D., Gad, F., Yaar, M., Eller, M. S., Nehal, U. S., Gilchrest, B. A. Mechanisms and implications of the age-associated decrease in DNA repair capacity.
Key Words: aging • DNA damage repair • DNA photoproducts • nucleotide excision repair
This article has been cited by other articles:
|
|
 |
|
  J. Y. Kim, Y. J. Hyun, Y. Jang, B. K. Lee, J. S. Chae, S. E. Kim, H. Y. Yeo, T.-S. Jeong, D. W. Jeon, and J. H. Lee Lipoprotein-associated phospholipase A2 activity is associated with coronary artery disease and markers of oxidative stress: a case-control study Am. J. Clinical Nutrition, September 1, 2008; 88(3): 630 - 637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I.-Y. Chang, M. Jin, S. P. Yoon, C.-K. Youn, Y. Yoon, S.-P. Moon, J.-W. Hyun, J. Y. Jun, and H. J. You Senescence-Dependent MutS{alpha} Dysfunction Attenuates Mismatch Repair Mol. Cancer Res., June 1, 2008; 6(6): 978 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Reddy Thavanati, K. R. Kanala, A. E. de Dios, and J. M. Cantu Garza Age-Related Correlation Between Antioxidant Enzymes and DNA Damage With Smoking and Body Mass Index J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2008; 63(4): 360 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Chen, C. N. Hales, and S. E. Ozanne DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res., December 3, 2007; 35(22): 7417 - 7428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Gorbunova, A. Seluanov, Z. Mao, and C. Hine Changes in DNA repair during aging Nucleic Acids Res., December 3, 2007; 35(22): 7466 - 7474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Lovell and W. R. Markesbery Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease Nucleic Acids Res., December 3, 2007; 35(22): 7497 - 7504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Adair, S. C. Maloney, G. A. Dement, K. J. Wertzler, M. J. Smerdon, and R. Reeves High-Mobility Group A1 Proteins Inhibit Expression of Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A Cancer Res., July 1, 2007; 67(13): 6044 - 6052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Demirbag, R. Yilmaz, A. Kocyigit, and S. Guzel Effect of Coronary Angiography on Oxidative DNA Damage Observed in Circulating Lymphocytes Angiology, April 1, 2007; 58(2): 141 - 147. [Abstract] [PDF]
|
|
|
|
 |
|
 S. C. Gehen, P. F. Vitiello, R. A. Bambara, P. C. Keng, and M. A. O'Reilly Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L716 - L724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Shen, M. Desai, M. Agrawal, D. O. Kennedy, R. T. Senie, R. M. Santella, and M. B. Terry Polymorphisms in nucleotide excision repair genes and DNA repair capacity phenotype in sisters discordant for breast cancer. Cancer Epidemiol. Biomarkers Prev., September 1, 2006; 15(9): 1614 - 1619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Arad, N. Konnikov, D. A. Goukassian, and B. A. Gilchrest T-oligos augment UV-induced protective responses in human skin FASEB J, September 1, 2006; 20(11): 1895 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Cabelof, Y. Ikeno, A. Nyska, R. A. Busuttil, N. Anyangwe, J. Vijg, L. H. Matherly, J. D. Tucker, S. H. Wilson, A. Richardson, et al. Haploinsufficiency in DNA Polymerase {beta} Increases Cancer Risk with Age and Alters Mortality Rate. Cancer Res., August 1, 2006; 66(15): 7460 - 7465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gu, M. R. Spitz, H. Zhao, J. Lin, H.B. Grossman, C. P. Dinney, and X. Wu Roles of tumor suppressor and telomere maintenance genes in cancer and aging--an epidemiological study Carcinogenesis, October 1, 2005; 26(10): 1741 - 1747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Wing and D B Richardson Age at exposure to ionising radiation and cancer mortality among Hanford workers: follow up through 1994 Occup. Environ. Med., July 1, 2005; 62(7): 465 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Xu, G. Spivak, D. L. Mitchell, T. Mori, J. R. McCarrey, C. A. McMahan, R. B. Walter, P. C. Hanawalt, and C. A. Walter Nucleotide Excision Repair Activity Varies Among Murine Spermatogenic Cell Types Biol Reprod, July 1, 2005; 73(1): 123 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Blankenburg, I. R. Konig, R. Moessner, P. Laspe, K.-M. Thoms, U. Krueger, S. G. Khan, G. Westphal, C. Berking, M. Volkenandt, et al. Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study Carcinogenesis, June 1, 2005; 26(6): 1085 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Neri, A. Gardini, A. Facchini, F. Olivieri, C. Franceschi, G. Ravaglia, and E. Mariani Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells From Differently Aged Participants J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2005; 60(3): 285 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Mahroos, M. Yaar, T. J. Phillips, J. Bhawan, and B. A. Gilchrest Effect of Sunscreen Application on UV-Induced Thymine Dimers Arch Dermatol, November 1, 2002; 138(11): 1480 - 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Muotri, M. C.N. Marchetto, M. F. Suzuki, K. Okazaki, C. F.P. Lotfi, G. Brumatti, G. P. Amarante-Mendes, and C. F.M. Menck Low amounts of the DNA repair XPA protein are sufficient to recover UV-resistance Carcinogenesis, June 1, 2002; 23(6): 1039 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Landi, A. Baccarelli, A. C. Pesatori, M. Hedayati, L. Grossman, M. A. Tucker, and R. E. Tarone RESPONSE: Re: DNA Repair, Dysplastic Nevi, and Sunlight Sensitivity in the Development of Cutaneous Malignant Melanoma J Natl Cancer Inst, May 15, 2002; 94(10): 773 - 774. [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Smith and Y. R. Seo p53 regulation of DNA excision repair pathways Mutagenesis, March 1, 2002; 17(2): 149 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Hamilton, H. Van Remmen, J. A. Drake, H. Yang, Z. M. Guo, K. Kewitt, C. A. Walter, and A. Richardson Does oxidative damage to DNA increase with age? PNAS, August 17, 2001; (2001) 171202698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Jiang, J. Z. Tsien, P. G. Schultz, and Y. Hu The effects of aging on gene expression in the hypothalamus and cortex of mice PNAS, February 13, 2001; 98(4): 1930 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Hamilton, H. Van Remmen, J. A. Drake, H. Yang, Z. M. Guo, K. Kewitt, C. A. Walter, and A. Richardson Does oxidative damage to DNA increase with age? PNAS, August 28, 2001; 98(18): 10469 - 10474. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
