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-tocopherol content of mitochondria on the production of superoxide anion radicals
Department of Biological Sciences, Southern Methodist University, Dallas, Texas 75275, USA
1Correspondence: Department of Biological Sciences, Southern Methodist University, 220 Fondren Science Bldg., Dallas, TX 75275, USA. E-mail: rsohal{at}mail.smu.edu
The effects of coenzyme Q10 (CoQ10) and
-tocopherol on the rate of mitochondrial superoxide anion radical
(
) generation were examined in
skeletal muscle, liver, and kidney of 24-month-old mice. Mice were
orally administered -tocopherol (200
mg·kg-1·day-1) alone, CoQ10
(123 mg·kg-1·day-1) alone, or the two
together for 13 wk. Administration of -tocopherol resulted in an
~sevenfold elevation of mitochondrial -tocopherol content. Intake
of CoQ10 alone caused an ~fivefold increase in CoQ
content (CoQ9 and/or CoQ10) and -tocopherol
of mitochondria. The rate of generation by submitochondrial particles (SMPs) was inversely related
to their -tocopherol content but unrelated to CoQ content.
Experimental in vitro augmentation of SMPs with varying
amounts of -tocopherol caused an up to ~50% decrease in the rate
of generation. Similar in
vitro augmentations of SMPs with CoQ10 had
previously been found to have no effect on the rate of
generation The
CoQ10-induced elevation of -tocopherol in the present
study was inferred to be due to a ‘sparing/regeneration’ by CoQ.
Results indicate the involvement of -tocopherol in the elimination
of mitochondrially generated .—Lass,
A., Sohal, R. S. Effect of coenzyme Q10 and
-tocopherol content of mitochondria on the production of superoxide
anion radicals.
Key Words: antioxidants • free radicals • oxidative stress • aging
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