| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
1Correspondence: Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada. E-mail: vogel{at}mshri.on.ca
Multicellular life relies on the presence of extracellular matrix to provide scaffolding for cells and tissue compartments. To provide communication between cells and tissues, a multitude of cell surface receptors are triggered by soluble ligands and components of the extracellular matrix. A large family of these receptors transmit signals through the use of an intrinsic tyrosine kinase function. The subgroup of discoidin domain receptors (DDRs) is distinguished from other members of the receptor tyrosine kinase family by a discoidin homology repeat in their extracellular domains that is also found in a variety of other transmembrane and secreted proteins. Sequence comparisons show that non-mammalian orthologs of DDRs exist: three closely related genes in Caenorhabditis and one in the sponge Geodia cydonium. Recently, various types of collagen have been identified as the ligands for the two mammalian discoidin domain receptor tyrosine kinases, DDR1 and DDR2. The binding of collagen to DDRs results in a delayed but sustained tyrosine kinase activation. Both receptors display several potential tyrosine phosphorylation sites that are able to relay the signal by interacting with cytoplasmic effector proteins. The potential cross-talk to other receptors for collagen and the clinical aspects of DDR function are discussed.—Vogel, W. Discoidin domain receptors: structural relations and functional implications.
Key Words: receptor tyrosine kinase • collagen signaling
This article has been cited by other articles:
|
|
 |
|
  Y. Zeng, Y. Takada, S. Kjellstrom, K. Hiriyanna, A. Tanikawa, E. Wawrousek, N. Smaoui, R. Caruso, R. A. Bush, and P. A. Sieving RS-1 Gene Delivery to an Adult Rs1h Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked Retinoschisis Invest. Ophthalmol. Vis. Sci., September 1, 2004; 45(9): 3279 - 3285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takada, R. N. Fariss, A. Tanikawa, Y. Zeng, D. Carper, R. Bush, and P. A. Sieving A Retinal Neuronal Developmental Wave of Retinoschisin Expression Begins in Ganglion Cells during Layer Formation Invest. Ophthalmol. Vis. Sci., September 1, 2004; 45(9): 3302 - 3312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Heinzelmann-Schwarz, M. Gardiner-Garden, S. M. Henshall, J. Scurry, R. A. Scolyer, M. J. Davies, M. Heinzelmann, L. H. Kalish, A. Bali, J. G. Kench, et al. Overexpression of the Cell Adhesion Molecules DDR1, Claudin 3, and Ep-CAM in Metaplastic Ovarian Epithelium and Ovarian Cancer Clin. Cancer Res., July 1, 2004; 10(13): 4427 - 4436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Matsuyama, L. Wang, W. L. Farrar, M. Faure, and T. Yoshimura Activation of Discoidin Domain Receptor 1 Isoform b with Collagen Up-Regulates Chemokine Production in Human Macrophages: Role of p38 Mitogen-Activated Protein Kinase and NF-{kappa}B J. Immunol., February 15, 2004; 172(4): 2332 - 2340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Piao, M. Kondo, M. Nakamura, H. Terasaki, and Y. Miyake Multifocal Electroretinograms in X-Linked Retinoschisis Invest. Ophthalmol. Vis. Sci., November 1, 2003; 44(11): 4920 - 4930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. W. H. Wu and R. S. Molday Defective Discoidin Domain Structure, Subunit Assembly, and Endoplasmic Reticulum Processing of Retinoschisin are Primary Mechanisms Responsible for X-linked Retinoschisis J. Biol. Chem., July 18, 2003; 278(30): 28139 - 28146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Varney, H. Ho, C. Petty, and D. D. Blumberg A novel disintegrin domain protein affects early cell type specification and pattern formation in Dictyostelium Development, March 7, 2003; 129(10): 2381 - 2389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Wang, C. T. Waters, A. M.K. Rothman, T. J. Jakins, K. Romisch, and D. Trump Intracellular retention of mutant retinoschisin is the pathological mechanism underlying X-linked retinoschisis Hum. Mol. Genet., November 15, 2002; 11(24): 3097 - 3105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ortega and Z. Werb New functional roles for non-collagenous domains of basement membrane collagens J. Cell Sci., November 15, 2002; 115(22): 4201 - 4214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Curat, M. Eck, X. Dervillez, and W. F. Vogel Mapping of Epitopes in Discoidin Domain Receptor 1 Critical for Collagen Binding J. Biol. Chem., November 30, 2001; 276(49): 45952 - 45958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yamashiro, H. Kamohara, J.-M. Wang, D. Yang, W.-H. Gong, and T. Yoshimura Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses J. Leukoc. Biol., May 1, 2001; 69(5): 698 - 704. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. F. Vogel, A. Aszódi, F. Alves, and T. Pawson Discoidin Domain Receptor 1 Tyrosine Kinase Has an Essential Role in Mammary Gland Development Mol. Cell. Biol., April 15, 2001; 21(8): 2906 - 2917. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. J. Kuo, K. R. LaMontagne , Jr., G. Garcia-Cardena, B. D. Ackley, D. Kalman, S. Park, R. Christofferson, J. Kamihara, Y.-H. Ding, K.-M. Lo, et al. Oligomerization-dependent Regulation of Motility and Morphogenesis by the Collagen XVIII NC1/Endostatin Domain J. Cell Biol., March 19, 2001; 152(6): 1233 - 1246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Molday, D. Hicks, C. G. Sauer, B. H. F. Weber, and R. S. Molday Expression of X-Linked Retinoschisis Protein RS1 in Photoreceptor and Bipolar Cells Invest. Ophthalmol. Vis. Sci., March 1, 2001; 42(3): 816 - 825. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Varani, D. Spearman, P. Perone, S. E. G. Fligiel, S. C. Datta, Z. Q. Wang, Y. Shao, S. Kang, G. J. Fisher, and J. J. Voorhees Inhibition of Type I Procollagen Synthesis by Damaged Collagen in Photoaged Skin and by Collagenase-Degraded Collagen in Vitro Am. J. Pathol., March 1, 2001; 158(3): 931 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Bhatt, T. Tomoda, Y. Fang, and M. E. Hatten Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons Genes & Dev., September 1, 2000; 14(17): 2216 - 2228. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Lu, S.-Y. Chen, H.-H. Chua, Y.-S. Liu, Y.-T. Huang, Y. Chang, J.-Y. Chen, T.-S. Sheen, and C.-H. Tsai Upregulation of Tyrosine Kinase TKT by the Epstein-Barr Virus Transactivator Zta J. Virol., August 15, 2000; 74(16): 7391 - 7399. [Abstract] [Full Text]
|
|
|
|
|
|
C. Grayson, S. N.M. Reid, J. A. Ellis, A. Rutherford, J. C. Sowden, J. R.W. Yates, D. B. Farber, and D. Trump Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells Hum. Mol. Genet., July 22, 2000; 9(12): 1873 - 1879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. W. RAINES, H. KOYAMA, and N. O. CARRAGHER The Extracellular Matrix Dynamically Regulates Smooth Muscle Cell Responsiveness to PDGF Ann. N.Y. Acad. Sci., May 1, 2000; 902(1): 39 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Vogel, C. Brakebusch, R. Fassler, F. Alves, F. Ruggiero, and T. Pawson Discoidin Domain Receptor 1 Is Activated Independently of beta 1 Integrin J. Biol. Chem., February 25, 2000; 275(8): 5779 - 5784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kobuke, Y. Furukawa, M. Sugai, K. Tanigaki, N. Ohashi, A. Matsumori, S. Sasayama, T. Honjo, and K. Tashiro ESDN, a Novel Neuropilin-like Membrane Protein Cloned from Vascular Cells with the Longest Secretory Signal Sequence among Eukaryotes, Is Up-regulated after Vascular Injury J. Biol. Chem., August 31, 2001; 276(36): 34105 - 34114. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
