HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by STEIN, G. S. Articles by MCNEIL, S. Search for Related Content PubMed PubMed Citation Articles by STEIN, G. S. Articles by MCNEIL, S.

Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions

Department of Cell Biology and Cancer Center, University of Massachusetts Medical Center, Worcester, Massachusetts. E-mail: Gary.Stein@banyan.ummed.edu

¹Correspondence: Department of Cell Biology and Cancer Center, University of Massachusetts Medical Center, 55 Lake Ave. North, Worcester, Massachusetts. E-mail: Gary.Stein{at}banyan.ummed.edu

Components of nuclear architecture are functionally interrelated with control of gene expression. There is growing appreciation that multiple levels of nuclear organization integrate the regulatory cues that support activation and suppression of genes as well as the processing of gene transcripts. The linear representation of genes and promoter elements provide the potential for responsiveness to physiological regulatory signals. Parameters of chromatin structure and nucleosome organization support synergism between activities at independent regulatory sequences and render promoter elements accessible or refractory to transcription factors. Association of genes, transcription factors, and the machinery for transcript processing with the nuclear matrix facilitates fidelity of gene expression within the three-dimensional context of nuclear architecture. Mechanisms must be defined that couple nuclear morphology with enzymatic parameters of gene expression. The recent characterization of factors that mediate chromatin remodeling and identification of intranuclear targeting signals that direct transcription factors to subnuclear domains where gene expression occurs link genetic and structural components of transcriptional control. Nuclear reorganization and aberrant intranuclear trafficking of transcription factors for developmental and tissue-specific control occurs in tumor cells and in neurological disorders. Compromises in nuclear structure-function interrelationships can occur as a consequence of microgravity-mediated perturbations in cellular architecture.—Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., Pockwinse, S. H., McNeil, S. Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions.

Key Words: transcription • chromatin • nucleosomes • nuclear matrix

This article has been cited by other articles:

				T. K. Chatterjee and R. A. Fisher RGS12TS-S Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional Repression Mol. Cell. Biol., June 15, 2002; 22(12): 4334 - 4345. [Abstract] [Full Text] [PDF]

				Y. Wang, D. C. Newton, T. L. Miller, A.-M. Teichert, M. J. Phillips, M. S. Davidoff, and P. A. Marsden An Alternative Promoter of the Human Neuronal Nitric Oxide Synthase Gene Is Expressed Specifically in Leydig Cells Am. J. Pathol., January 1, 2002; 160(1): 369 - 380. [Abstract] [Full Text] [PDF]