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(The FASEB Journal. 1999;13:883-892.)
© 1999 FASEB

Research Communications

Plasma phospholipid transfer protein prevents vascular endothelium dysfunction by delivering {alpha}-tocopherol to endothelial cells

CATHERINE DESRUMAUX, VALÉRIE DECKERT, ANNE ATHIAS, DAVID MASSON, GÉRARD LIZARD, VIVIANE PALLEAU, PHILIPPE GAMBERT and LAURENT LAGROST1

Laboratoire de Biochimie des Lipoprotéines-INSERM U498, Hôpital du Bocage, BP 1542, 21034 Dijon Cedex, France

1Correspondence: Laboratoire de Biochimie des Lipoprotéines, INSERM U498, Hôpital du Bocage, BP 1542, 21034 Dijon, France. E-mail: Laurent.Lagrost{at}u-bourgogne.fr

{alpha}-tocopherol, the most potent antioxidant form of vitamin E, is mainly bound to lipoproteins in plasma and its incorporation into the vascular wall can prevent the endothelium dysfunction at an early stage of atherogenesis. In the present study, the plasma phospholipid transfer protein (PLTP) was shown to promote the net mass transfer of {alpha}-tocopherol from high density lipoproteins (HDL) and {alpha}-tocopherol-albumin complexes toward {alpha}-tocopherol-depleted, oxidized low density lipoproteins (LDL). The facilitated transfer reaction of {alpha}-tocopherol could be blocked by specific anti-PLTP antibodies. These observations indicate that PLTP may restore the antioxidant potential of plasma LDL at an early stage of the oxidation cascade that subsequently leads to cellular damages. In addition, the present study demonstrated that the PLTP-mediated net mass transfer of {alpha}-tocopherol can constitute a new mechanism for the incorporation of {alpha}-tocopherol into the vascular wall in addition to the previously recognized LDL receptor and lipoprotein lipase pathways. In ex vivo studies on rabbit aortic segments, the impairment of the endothelium-dependent arterial relaxation induced by oxidized LDL was found to be counteracted by a pretreatment with purified PLTP and {alpha}-tocopherol-albumin complexes, and both the maximal response and the sensitivity to acetylcholine were significantly improved. We conclude that PLTP, by supplying oxidized LDL and endothelial cells with {alpha}-tocopherol through a net mass transfer reaction may play at least two distinct beneficial roles in preventing endothelium damage, i.e., the antioxidant protection of LDL and the preservation of a normal relaxing function of vascular endothelial cells.—Desrumaux, C., Deckert, V., Athias, A., Masson, D., Lizard, G., Palleau, V., Gambert, P., Lagrost, L. Plasma phospholipid transfer protein prevents vascular endothelium dysfunction by delivering {alpha}-tocopherol to endothelial cells.


Key Words: acetylcholine • aorta • lipid transfer protein • oxidized LDL • vitamin E




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