| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Reviews |
Department of Pathology, University of Natal Medical School, Durban, South Africa
1Correspondence: Department of Pathology, University of Natal Medical School, Private Bag 7, Congella 4013, Durban, Kwazulu-Natal, South Africa. E-mail: donnellanr{at}med.und.ac.za
Regulators of the cell cycle such as cyclin E play an important part in neoplasia. The cyclin E protein forms a partnership with a specific protein kinase. This complex phosphorylates key substrates to initiate DNA synthesis. Cyclin-dependent kinase inhibitors (CKIs) are able to suppress the activity of cyclin E. Various substances (including proteins produced by oncogenic viruses) affect cyclin E directly or indirectly through an interaction with CKIs. These interactions are important in elucidating the mechanisms of neoplasia. They may also provide prognostic information in a wide range of common cancers. Cyclin E may even be a target for treatment of cancers in the future.—Donnellan, R., Chetty, R. Cyclin E in human cancers.
Key Words: cell cycle • cyclins • cyclin-dependent kinase • CKIs
This article has been cited by other articles:
|
|
 |
|
  X. Zheng, X.-M. Rao, J. G. Gomez-Gutierrez, H. Hao, K. M. McMasters, and H. S. Zhou Adenovirus E1B55K Region Is Required To Enhance Cyclin E Expression for Efficient Viral DNA Replication J. Virol., April 1, 2008; 82(7): 3415 - 3427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A N A Milne, R Carvalho, M Jansen, E K Kranenbarg, C J H van de Velde, F M Morsink, A R Musler, M A J Weterman, and G J A Offerhaus Cyclin E low molecular weight isoforms occur commonly in early-onset gastric cancer and independently predict survival J. Clin. Pathol., March 1, 2008; 61(3): 311 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Deep, N. H. Oberlies, D. J. Kroll, and R. Agarwal Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells Carcinogenesis, July 1, 2007; 28(7): 1533 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. McEvoy, U. Kossatz, N. Malek, and J. D. Singer Constitutive Turnover of Cyclin E by Cul3 Maintains Quiescence Mol. Cell. Biol., May 15, 2007; 27(10): 3651 - 3666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Spruck, D. Sun, H. Fiegl, C. Marth, E. Mueller-Holzner, G. Goebel, M. Widschwendter, and S. I. Reed Detection of low molecular weight derivatives of cyclin e1 is a function of cyclin e1 protein levels in breast cancer. Cancer Res., July 15, 2006; 66(14): 7355 - 7360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. P. Jackson, S. I. Reed, and S. B. Haase Distinct mechanisms control the stability of the related s-phase cyclins clb5 and clb6. Mol. Cell. Biol., March 1, 2006; 26(6): 2456 - 2466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Potemski, E. Pluciennik, A. K. Bednarek, R. Kusinska, D. Jesionek-Kupnicka, G. Pasz-Walczak, C. Watala, and R. Kordek Cyclin E Expression in Operable Breast Cancer Quantified Using Real-Time RT-PCR: A Comparative Study with Immunostaining Jpn. J. Clin. Oncol., March 1, 2006; 36(3): 142 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mani and E. P. Gelmann The Ubiquitin-Proteasome Pathway and Its Role in Cancer J. Clin. Oncol., July 20, 2005; 23(21): 4776 - 4789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. I. Reed Deregulation of Cyclin E in Cancer Am. Assoc. Cancer Res. Educ. Book, April 1, 2005; 2005(1): 53 - 56. [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Bani-Hani, N. M. Almasri, Y. S. Khader, F. M. Sheyab, and H. N. Karam Combined Evaluation of Expressions of Cyclin E and p53 Proteins as Prognostic Factors for Patients with Gastric Cancer Clin. Cancer Res., February 15, 2005; 11(4): 1447 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schoonjans, L. Dubuquoy, J. Mebis, E. Fayard, O. Wendling, C. Haby, K. Geboes, and J. Auwerx Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation PNAS, February 8, 2005; 102(6): 2058 - 2062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yu, J. Lin, Y. Xiao, J. Han, X. Zhang, H. Jia, Y. Tang, and Y. Li Induction of Cell-Cycle Arrest by all-trans Retinoic Acid in Mouse Embryonic Palatal Mesenchymal (MEPM) Cells Toxicol. Sci., February 1, 2005; 83(2): 349 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-P. Lin, S. K. Kulp, P.-H. Tseng, Y.-T. Yang, C.-C. Yang, C.-S. Chen, and C.-S. Chen Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G1 arrest via multiple signaling mechanisms Mol. Cancer Ther., December 1, 2004; 3(12): 1671 - 1680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Schneider and M. Kulesz-Martin Destructive cycles: the role of genomic instability and adaptation in carcinogenesis Carcinogenesis, November 1, 2004; 25(11): 2033 - 2044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Richard-Parpaillon, R. A. Cosgrove, C. Devine, A. E. Vernon, and A. Philpott G1/S phase cyclin-dependent kinase overexpression perturbs early development and delays tissue-specific differentiation in Xenopus Development, June 1, 2004; 131(11): 2577 - 2586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Harwell, B. B. Mull, D. C. Porter, and K. Keyomarsi Activation of Cyclin-dependent Kinase 2 by Full Length and Low Molecular Weight Forms of Cyclin E in Breast Cancer Cells J. Biol. Chem., March 26, 2004; 279(13): 12695 - 12705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A A Khan, P D Abel, K S Chaudhary, Z Gulzar, G W H Stamp, and E-N Lalani Inverse correlation between high level expression of cyclin E and proliferation index in transitional cell carcinoma of the bladder Mol. Pathol., December 1, 2003; 56(6): 353 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Qu, J. N. Weiss, and W. R. MacLellan Regulation of the mammalian cell cycle: a model of the G1-to-S transition Am J Physiol Cell Physiol, February 1, 2003; 284(2): C349 - C364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wiebusch, J. Asmar, R. Uecker, and C. Hagemeier Human cytomegalovirus immediate-early over protein 2 (IE2)-mediated activation of cyclin E is cell-cycle-independent and forces S-phase entry in IE2-arrested cells J. Gen. Virol., January 1, 2003; 84(1): 51 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Geisen and T. Moroy The Oncogenic Activity of Cyclin E Is Not Confined to Cdk2 Activation Alone but Relies on Several Other, Distinct Functions of the Protein J. Biol. Chem., October 11, 2002; 277(42): 39909 - 39918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Spruck, H. Strohmaier, O. Sangfelt, H. M. Muller, M. Hubalek, E. Muller-Holzner, C. Marth, M. Widschwendter, and S. I. Reed hCDC4 Gene Mutations in Endometrial Cancer Cancer Res., August 15, 2002; 62(16): 4535 - 4539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gao and D. R. Richardson The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: the mechanisms involved in inhibiting cell-cycle progression Blood, August 1, 2001; 98(3): 842 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Porter and K. Keyomarsi Novel splice variants of cyclin E with altered substrate specificity Nucleic Acids Res., December 1, 2000; 28(23): e101 - e101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ravanko, K. Järvinen, A. Paasinen-Sohns, and E. Hölttä Loss of p27Kip1 from Cyclin E/Cyclin-dependent Kinase (CDK) 2 but not from Cyclin D1/CDK4 Complexes in Cells Transformed by Polyamine Biosynthetic Enzymes Cancer Res., September 1, 2000; 60(18): 5244 - 5253. [Abstract] [Full Text]
|
|
|
|
|
|
R. M. Harwell, D. C. Porter, C. Danes, and K. Keyomarsi Processing of Cyclin E Differs between Normal and Tumor Breast Cells Cancer Res., January 1, 2000; 60(2): 481 - 489. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
