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A Special Series of Reviews: RNA Localization |
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
ABSTRACT
Cytoplasmic localization of mRNA molecules has emerged as a powerful mechanism for generating spatially restricted gene expression. This process is an important contributor to cell polarity in both somatic cells and oocytes, and can provide the basis for patterning during embryonic development. In vertebrates, this phenomenon is perhaps best documented in the frog, Xenopus laevis, where polarity along the animal-vegetal axis coincides with the localization of numerous mRNA molecules. Research over the last several years has made exciting progress toward understanding the molecular mechanisms underlying cytoplasmic mRNA localization.—Mowry, K. L., Cote, C. A. RNA sorting in Xenopus oocytes and embryos.
1 Correspondence: Brown University, 69 Brown St., Providence, RI 02912, USA. E-mail: kimberly_mowry{at}brown.edu
Key Words: RNA localization • A-V axis • polarity • oogenesis ·RNA binding protein
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