| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Anatomy and Cell Biology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814, USA
1Correspondence: Department of Anatomy and Cell Biology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. E-mail: msrivastava{at}usuhs.mil
Cells require optimum protein synthetic activity in order to support
cell proliferation, maintain homeostatic and metabolic integrity, and
repair damage. Since growth depends on protein synthesis through
ribosome biogenesis, the control of biosynthesis of ribosomes is
necessarily a key element for control of growth. Nucleolin is a major
nucleolar protein of exponentially growing eukaryotic cells, which is
directly involved in the regulation of ribosome biogenesis and
maturation. The highly conserved nucleolin contains three major domains
through which it controls the organization of nucleolar chromatin,
packaging of pre-RNA, rDNA transcription, and ribosome assembly.
Numerous reports have implicated the involvement of nucleolin either
directly or indirectly in the regulation of cell proliferation and
growth, cytokinesis, replication, embryogenesis, and nucleogenesis.
Nucleolin, an RNA binding protein, is also an autoantigen, a
transcriptional repressor, and a switch region targeting factor. In
addition, nucleolin exhibits autodegradation, DNA and RNA helicase
activities, and DNA-dependent ATPase activity. An interesting aspect of
nucleolin action is that it is a target for regulation by proteolysis,
methylation, ADP-ribosylation, and phosphorylation by CKII, cdc2,
PKC-
, cyclic AMP-dependent protein kinase, and ecto-protein kinase.
For these and other reasons, nucleolin is fundamental to the survival
and proliferation of cells. Considerable progress has been made in
recent years with the identification of new nucleolin binding proteins
that may mediate these many nucleolin-dependent functions. Nucleolin
also functions as a cell surface receptor, where it acts as a shuttling
protein between cytoplasm and nucleus, and thus can even provide a
mechanism for extracellular regulation of nuclear events. Exploration
of the regulation of this multifaceted protein in a remarkable number
of diverse functions is challenging.—Srivastava, M., Pollard, H. B. Molecular dissection of nucleolin's role in growth and cell
proliferation: new insights.
Key Words: nucleolin • ribosome biogenesis • phosphorylation • proteolysis • binding proteins • ligands • apoptosis • cell cycle
This article has been cited by other articles:
|
|
 |
|
  V. Stepanova, T. Lebedeva, A. Kuo, S. Yarovoi, S. Tkachuk, S. Zaitsev, K. Bdeir, I. Dumler, M. S. Marks, Y. Parfyonova, et al. Nuclear translocation of urokinase-type plasminogen activator Blood, July 1, 2008; 112(1): 100 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Calle, I. Ugrinova, A. L. Epstein, P. Bouvet, J.-J. Diaz, and A. Greco Nucleolin Is Required for an Efficient Herpes Simplex Virus Type 1 Infection J. Virol., May 15, 2008; 82(10): 4762 - 4773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Soundararajan, W. Chen, E. K. Spicer, N. Courtenay-Luck, and D. J. Fernandes The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells Cancer Res., April 1, 2008; 68(7): 2358 - 2365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, G. Tsaprailis, and G. T. Bowden Nucleolin Stabilizes Bcl-XL Messenger RNA in Response to UVA Irradiation Cancer Res., February 15, 2008; 68(4): 1046 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Tsou, K.-Y. Chang, W.-C. Wang, J. T. Tseng, W.-C. Su, L.-Y. Hung, W.-C. Chang, and B.-K. Chen Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2{alpha} in phorbol ester-treated non-small cell lung cancer A549 cells Nucleic Acids Res., January 17, 2008; 36(1): 217 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-T. Lee, P.-C. Liao, W.-C. Chang, and J. T. Tseng Epidermal Growth Factor Increases the Interaction between Nucleolin and Heterogeneous Nuclear Ribonucleoprotein K/Poly(C) Binding Protein 1 Complex to Regulate the Gastrin mRNA Turnover Mol. Biol. Cell, December 1, 2007; 18(12): 5004 - 5013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Teng, A. C. Girvan, L. K. Casson, W. M. Pierce Jr., M. Qian, S. D. Thomas, and P. J. Bates AS1411 Alters the Localization of a Complex Containing Protein Arginine Methyltransferase 5 and Nucleolin Cancer Res., November 1, 2007; 67(21): 10491 - 10500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shi, Y. Huang, H. Zhou, X. Song, S. Yuan, Y. Fu, and Y. Luo Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin Blood, October 15, 2007; 110(8): 2899 - 2906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Xie, I. Kobayashi, T. Kiyoshima, H. Yamaza, J.-y. Honda, K. Takahashi, N. Enoki, A. Akamine, and H. Sakai Functional Implication of Nucleolin in the Mouse First Molar Development J. Biol. Chem., August 10, 2007; 282(32): 23275 - 23283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ma, S. Matsunaga, H. Takata, R. Ono-Maniwa, S. Uchiyama, and K. Fukui Nucleolin functions in nucleolus formation and chromosome congression J. Cell Sci., June 15, 2007; 120(12): 2091 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kusakawa, T. Shimakami, S. Kaneko, K. Yoshioka, and S. Murakami Functional Interaction of Hepatitis C Virus NS5B with Nucleolin GAR Domain J. Biochem., June 1, 2007; 141(6): 917 - 927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Grinstein, Y. Du, S. Santourlidis, J. Christ, M. Uhrberg, and P. Wernet Nucleolin Regulates Gene Expression in CD34-positive Hematopoietic Cells J. Biol. Chem., April 27, 2007; 282(17): 12439 - 12449. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rickards, S. J. Flint, M. D. Cole, and G. LeRoy Nucleolin Is Required for RNA Polymerase I Transcription In Vivo Mol. Cell. Biol., February 1, 2007; 27(3): 937 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pontvianne, I. Matia, J. Douet, S. Tourmente, F. J. Medina, M. Echeverria, and J. Saez-Vasquez Characterization of AtNUC-L1 Reveals a Central Role of Nucleolin in Nucleolus Organization and Silencing of AtNUC-L2 Gene in Arabidopsis Mol. Biol. Cell, February 1, 2007; 18(2): 369 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Ireson and L. R. Kelland Discovery and development of anticancer aptamers Mol. Cancer Ther., December 1, 2006; 5(12): 2957 - 2962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fahling, R. Mrowka, A. Steege, G. Nebrich, A. Perlewitz, P. B. Persson, and B. J. Thiele Translational Control of Collagen Prolyl 4-Hydroxylase-{alpha}(I) Gene Expression under Hypoxia J. Biol. Chem., September 8, 2006; 281(36): 26089 - 26101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lou, N. Fatima, Z. Xiao, S. Stauffer, G. Smythers, P. Greenwald, and I. U. Ali Proteomic profiling identifies cyclooxygenase-2-independent global proteomic changes by celecoxib in colorectal cancer cells. Cancer Epidemiol. Biomarkers Prev., September 1, 2006; 15(9): 1598 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Grinstein, Y. Shan, L. Karawajew, P. J. F. Snijders, C. J. L. M. Meijer, H.-D. Royer, and P. Wernet Cell Cycle-controlled Interaction of Nucleolin with the Retinoblastoma Protein and Cancerous Cell Transformation J. Biol. Chem., August 4, 2006; 281(31): 22223 - 22235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. J. Becherel, N. Gueven, G. W. Birrell, V. Schreiber, A. Suraweera, B. Jakob, G. Taucher-Scholz, and M. F. Lavin Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription Hum. Mol. Genet., July 15, 2006; 15(14): 2239 - 2249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Girvan, Y. Teng, L. K. Casson, S. D. Thomas, S. Juliger, M. W. Ball, J. B. Klein, W. M. Pierce Jr., S. S. Barve, and P. J. Bates AGRO100 inhibits activation of nuclear factor-{kappa}B (NF-{kappa}B) by forming a complex with NF-{kappa}B essential modulator (NEMO) and nucleolin. Mol. Cancer Ther., July 1, 2006; 5(7): 1790 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Huddleson, N. Ahmad, and J. B. Lingrel Up-regulation of the KLF2 Transcription Factor by Fluid Shear Stress Requires Nucleolin J. Biol. Chem., June 2, 2006; 281(22): 15121 - 15128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Huang, H. Shi, H. Zhou, X. Song, S. Yuan, and Y. Luo The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin Blood, May 1, 2006; 107(9): 3564 - 3571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimakami, M. Honda, T. Kusakawa, T. Murata, K. Shimotohno, S. Kaneko, and S. Murakami Effect of Hepatitis C Virus (HCV) NS5B-Nucleolin Interaction on HCV Replication with HCV Subgenomic Replicon. J. Virol., April 1, 2006; 80(7): 3332 - 3340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, D. Bhatia, H. Xia, V. Castranova, X. Shi, and F. Chen Nucleolin links to arsenic-induced stabilization of GADD45{alpha} mRNA Nucleic Acids Res., January 18, 2006; 34(2): 485 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hirano, Y. Miki, Y. Hirai, R. Sato, T. Itoh, A. Hayashi, M. Yamanaka, S. Eda, and M. Beppu A Multifunctional Shuttling Protein Nucleolin Is a Macrophage Receptor for Apoptotic Cells J. Biol. Chem., November 25, 2005; 280(47): 39284 - 39293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Austin, R. J. Leary, and A. Shimamura The Shwachman-Diamond SBDS protein localizes to the nucleolus Blood, August 15, 2005; 106(4): 1253 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Joo, G. B. ten Dam, T. H. van Kuppevelt, T. Toida, R. J. Linhardt, and Y. S. Kim Nucleolin: acharan sulfate-binding protein on the surface of cancer cells Glycobiology, January 1, 2005; 15(1): 1 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Otake, T. K. Sengupta, S. Bandyopadhyay, E. K. Spicer, and D. J. Fernandes Retinoid-Induced Apoptosis in HL-60 Cells Is Associated with Nucleolin Down-Regulation and Destabilization of Bcl-2 mRNA Mol. Pharmacol., January 1, 2005; 67(1): 319 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Khurts, K. Masutomi, L. Delgermaa, K. Arai, N. Oishi, H. Mizuno, N. Hayashi, W. C. Hahn, and S. Murakami Nucleolin Interacts with Telomerase J. Biol. Chem., December 3, 2004; 279(49): 51508 - 51515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kahlina, I. Goren, J. Pfeilschifter, and S. Frank p68 DEAD Box RNA Helicase Expression in Keratinocytes: REGULATION, NUCLEOLAR LOCALIZATION, AND FUNCTIONAL CONNECTION TO PROLIFERATION AND VASCULAR ENDOTHELIAL GROWTH FACTOR GENE EXPRESSION J. Biol. Chem., October 22, 2004; 279(43): 44872 - 44882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Sheng, J. A. Lewis, and W. J. Chirico Nuclear and Nucleolar Localization of 18-kDa Fibroblast Growth Factor-2 Is Controlled by C-terminal Signals J. Biol. Chem., September 17, 2004; 279(38): 40153 - 40160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Sinclair and A. D. O'Brien Intimin Types {alpha}, {beta}, and {gamma} Bind to Nucleolin with Equivalent Affinity but Lower Avidity than to the Translocated Intimin Receptor J. Biol. Chem., August 6, 2004; 279(32): 33751 - 33758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bose, M. Basu, and A. K. Banerjee Role of Nucleolin in Human Parainfluenza Virus Type 3 Infection of Human Lung Epithelial Cells J. Virol., August 1, 2004; 78(15): 8146 - 8158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Singh, J. Laughlin, P. A. Kosinski, and L. R. Covey Nucleolin Is a Second Component of the CD154 mRNA Stability Complex That Regulates mRNA Turnover in Activated T Cells J. Immunol., July 15, 2004; 173(2): 976 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Mitra, S. L. Shaw, and S. R. Long Six nonnodulating plant mutants defective for Nod factor-induced transcriptional changes associated with the legume-rhizobia symbiosis PNAS, July 6, 2004; 101(27): 10217 - 10222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. K. Sengupta, S. Bandyopadhyay, D. J. Fernandes, and E. K. Spicer Identification of Nucleolin as an AU-rich Element Binding Protein Involved in bcl-2 mRNA Stabilization J. Biol. Chem., March 19, 2004; 279(12): 10855 - 10863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sakaguchi, M. Miyazaki, M. Takaishi, Y. Sakaguchi, E. Makino, N. Kataoka, H. Yamada, M. Namba, and N.-h. Huh S100C/A11 is a key mediator of Ca2+-induced growth inhibition of human epidermal keratinocytes J. Cell Biol., November 24, 2003; 163(4): 825 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Christian, J. Pilch, M. E. Akerman, K. Porkka, P. Laakkonen, and E. Ruoslahti Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels J. Cell Biol., November 24, 2003; 163(4): 871 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. D. Finger, L. Trantirek, C. Johansson, and J. Feigon Solution structures of stem-loop RNAs that bind to the two N-terminal RNA-binding domains of nucleolin Nucleic Acids Res., November 15, 2003; 31(22): 6461 - 6472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yoo, S. K. Wootton, G. Li, C. Song, and R. R. Rowland Colocalization and Interaction of the Porcine Arterivirus Nucleocapsid Protein with the Small Nucleolar RNA-Associated Protein Fibrillarin J. Virol., November 15, 2003; 77(22): 12173 - 12183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Yang, Y. Nie, Q. Zhao, Y. Su, M. Pypaert, H. Su, and R. Rabinovici Intracellular Localization of Differentially Regulated RNA-specific Adenosine Deaminase Isoforms in Inflammation J. Biol. Chem., November 14, 2003; 278(46): 45833 - 45842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Re Implications of intracrine hormone action for physiology and medicine Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H751 - H757. [Full Text] [PDF]
|
|
|
|
|
|
Y. Mi, S. D. Thomas, X. Xu, L. K. Casson, D. M. Miller, and P. J. Bates Apoptosis in Leukemia Cells Is Accompanied by Alterations in the Levels and Localization of Nucleolin J. Biol. Chem., February 28, 2003; 278(10): 8572 - 8579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hirano, S. Kaneko, T. Yamashita, H. Luo, W. Qin, Y. Shirota, T. Nomura, K. Kobayashi, and S. Murakami Direct Interaction between Nucleolin and Hepatitis C Virus NS5B J. Biol. Chem., February 7, 2003; 278(7): 5109 - 5115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Vallejo, E. Bryl, K. Klarskov, S. Naylor, C. M. Weyand, and J. J. Goronzy Molecular Basis for the Loss of CD28 Expression in Senescent T Cells J. Biol. Chem., November 27, 2002; 277(49): 46940 - 46949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Grinstein, P. Wernet, P. J.F. Snijders, F. Rosl, I. Weinert, W. Jia, R. Kraft, C. Schewe, M. Schwabe, S. Hauptmann, et al. Nucleolin as Activator of Human Papillomavirus Type 18 Oncogene Transcription in Cervical Cancer J. Exp. Med., October 21, 2002; 196(8): 1067 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Said, B. Krust, S. Nisole, J. Svab, J.-P. Briand, and A. G. Hovanessian The Anti-HIV Cytokine Midkine Binds the Cell Surface-expressed Nucleolin as a Low Affinity Receptor J. Biol. Chem., September 27, 2002; 277(40): 37492 - 37502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Morimoto, H. Okamura, and T. Haneji Interaction of Protein Phosphatase 1 Delta with Nucleolin in Human Osteoblastic Cells J. Histochem. Cytochem., September 1, 2002; 50(9): 1187 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Okuwaki, M. Tsujimoto, and K. Nagata The RNA Binding Activity of a Ribosome Biogenesis Factor, Nucleophosmin/B23, Is Modulated by Phosphorylation with a Cell Cycle-dependent Kinase and by Association with Its Subtype Mol. Biol. Cell, June 1, 2002; 13(6): 2016 - 2030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nisole, E. A. Said, C. Mische, M.-C. Prevost, B. Krust, P. Bouvet, A. Bianco, J.-P. Briand, and A. G. Hovanessian The Anti-HIV Pentameric Pseudopeptide HB-19 Binds the C-terminal End of Nucleolin and Prevents Anchorage of Virus Particles in the Plasma Membrane of Target Cells J. Biol. Chem., May 31, 2002; 277(23): 20877 - 20886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Yang, D. A. Maiguel, and F. Carrier Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins Nucleic Acids Res., May 15, 2002; 30(10): 2251 - 2260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lefebvre, P. Burlet, L. Viollet, S. Bertrandy, C. Huber, C. Belser, and A. Munnich A novel association of the SMN protein with two major non-ribosomal nucleolar proteins and its implication in spinal muscular atrophy Hum. Mol. Genet., May 1, 2002; 11(9): 1017 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Paiardini, D. Galati, B. Cervasi, G. Cannavo, L. Galluzzi, M. Montroni, D. Guetard, M. Magnani, G. Piedimonte, and G. Silvestri Exogenous Interleukin-2 Administration Corrects the Cell Cycle Perturbation of Lymphocytes from Human Immunodeficiency Virus-Infected Individuals J. Virol., November 15, 2001; 75(22): 10843 - 10855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Xu, F. Hamhouyia, S. D. Thomas, T. J. Burke, A. C. Girvan, W. G. McGregor, J. O. Trent, D. M. Miller, and P. J. Bates Inhibition of DNA Replication and Induction of S Phase Cell Cycle Arrest by G-rich Oligonucleotides J. Biol. Chem., November 9, 2001; 276(46): 43221 - 43230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Krust, R. Vienet, A. Cardona, C. Rougeot, E. Jacotot, C. Callebaut, G. Guichard, J. P. Briand, J. M. Grognet, A. G. Hovanessian, et al. The anti-HIV pentameric pseudopeptide HB-19 is preferentially taken up in vivo by lymphoid organs where it forms a complex with nucleolin PNAS, October 31, 2001; (2001) 221467298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rothenburg, F. Koch-Nolte, A. Rich, and F. Haag A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity PNAS, July 5, 2001; (2001) 121176998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cannavo', M. Paiardini, D. Galati, B. Cervasi, M. Montroni, G. De Vico, D. Guetard, M. L. Bocchino, I. Picerno, M. Magnani, et al. Abnormal intracellular kinetics of cell-cycle-dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: a novel biologic link between immune activation, accelerated T-cell turnover, and high levels of apoptosis Blood, March 15, 2001; 97(6): 1756 - 1764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Barel, M. Le Romancer, and R. Frade Activation of the EBV/C3d Receptor (CR2, CD21) on Human B Lymphocyte Surface Triggers Tyrosine Phosphorylation of the 95-kDa Nucleolin and Its Interaction with Phosphatidylinositol 3 Kinase J. Immunol., March 1, 2001; 166(5): 3167 - 3173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Juan and C. Cordon-Cardo Intranuclear Compartmentalization of Cyclin E during the Cell Cycle: Disruption of the Nucleoplasm-Nucleolar Shuttling of Cyclin E in Bladder Cancer Cancer Res., February 1, 2001; 61(3): 1220 - 1226. [Abstract] [Full Text]
|
|
|
|
|
|
H. Ginisty, G. Serin, L. Ghisolfi-Nieto, B. Roger, V. Libante, F. Amalric, and P. Bouvet Interaction of Nucleolin with an Evolutionarily Conserved Pre-ribosomal RNA Sequence Is Required for the Assembly of the Primary Processing Complex J. Biol. Chem., June 16, 2000; 275(25): 18845 - 18850. [Abstract] [Full Text] [PDF]
|
