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B the sensor of oxidative stress?
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0636, USA
1Correspondence: Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0636, USA. E-mail: karinoffice{at}ucsd.edu
NF-
B is a dimeric transcription factor that is involved in the
regulation of a large number of genes that control various aspects of
the immune and inflammatory response. It is activated by a variety of
stimuli ranging from cytokines, to various forms of radiation, to
oxidative stress (such as exposure to H2O2).
Recent studies have advanced our understanding of the signal
transduction pathway leading to NF-B activation by cytokines and
will provide insights for the mechanism by which NF-B is regulated
by oxidative stress. An important question that is yet to be answered
is whether reactive oxygen species play a physiological role in NF-B
activation.—Li, N., Karin, M. Is NF-B the sensor of oxidative
stress?
Key Words: IB degradation • IKK • reactive oxygen species • tumor necrosis factor • GSH
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