FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seeger, M.
Right arrow Articles by Dubiel, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seeger, M.
Right arrow Articles by Dubiel, W.
(The FASEB Journal. 1998;12:469-478.)
© 1998 FASEB

RESEARCH COMMUNICATION

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits

Michael Seegera, Regine Kraftc, Katherine Ferrella, Dawadschargal Bech-Otschira, Renate Dumdeya, Rüdiger Schadeb, Colin Gordond, Michael Naumanne, and Wolfgang Dubiela,1

a Institute of Biochemistry, Humboldt-University, Medical Faculty (Charité), 10117 Berlin, Germany
b Institute of Pharmacology and Toxicology, Humboldt-University, Medical Faculty (Charité), 10117 Berlin, Germany
c Max-Delbrück-Center, 13122 Berlin, Germany
d MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, U.K.
e Max-Planck-Institut für Infektionsbiologie, Abt. Molekulare Biologie, 10117 Berlin, Germany

A novel protein complex has been identified in human cells that has a molecular mass of approximately 450 kDa. It consists of at least eight different subunits including JAB1, the Jun activation-domain binding protein 1, and Trip15, the thyroid hormone receptor-interacting protein 15. The purified complex contains COP9 and COP11 protein homologs and is very similar, if not identical, to the plant COP9 complex involved in light-mediated signal transduction. The isolated JAB1-containing particle has kinase activity that phosphorylates I{kappa}B{alpha}, the carboxy terminus of p105, and Ser63 and/or Ser73 of the amino-terminal activation domain of c-Jun. The phosphorylation of c-Jun requires the carboxy terminus of the protein containing the DNA binding and dimerization domains. Three subunits of the new complex—Sgn3, Sgn5/JAB1, and Sgn6—exhibit sequence similarities to regulatory components of the 26S proteasome, which could indicate the existence of common substrate binding sites. Immunofluorescence staining reveals that the new complex shows a subcellular distribution similar to that of the 26S proteasome. The functional relationship of the two particles in regulating transcriptional activity is discussed. Considering the putative role of the complex in signal transduction and its widespread occurrence, we suggest the name JAB1-containing signalosome.—Seeger, M., Kraft, R., Ferrell, K., Bech-Otschir, D., Dumdey, R., Schade, R., Gordon, C., Naumann, M., Dubiel, W. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB J. 12, 469–478 (1998)


Key Words: protein kinase complex • phosphorylation • signalosome




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
M.-C. Hsu, C.-C. Huang, H.-C. Chang, T.-H. Hu, and W.-C. Hung
Overexpression of Jab1 in Hepatocellular Carcinoma and Its Inhibition by Peroxisome Proliferator-Activated Receptor{gamma} Ligands In vitro and In vivo
Clin. Cancer Res., July 1, 2008; 14(13): 4045 - 4052.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. M. N. Dohmann, M. P. Levesque, L. De Veylder, I. Reichardt, G. Jurgens, M. Schmid, and C. Schwechheimer
The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability
Development, June 1, 2008; 135(11): 2013 - 2022.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
M.-C. Hsu, H.-C. Chang, and W.-C. Hung
HER-2/neu transcriptionally activates Jab1 expression via the AKT/{beta}-catenin pathway in breast cancer cells
Endocr. Relat. Cancer, September 1, 2007; 14(3): 655 - 667.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Flaster, J. Bernhagen, T. Calandra, and R. Bucala
The Macrophage Migration Inhibitory Factor-Glucocorticoid Dyad: Regulation of Inflammation and Immunity
Mol. Endocrinol., June 1, 2007; 21(6): 1267 - 1280.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. d. S. Correia, Y. Miranda, N. Leonard, and R. J. Ulevitch
The Subunit CSN6 of the COP9 Signalosome Is Cleaved during Apoptosis
J. Biol. Chem., April 27, 2007; 282(17): 12557 - 12565.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
O. Harari-Steinberg, R. Cantera, S. Denti, E. Bianchi, E. Oron, D. Segal, and D. A Chamovitz
COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis.
Genes Cells, February 1, 2007; 12(2): 183 - 195.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
G. Gusmaroli, P. Figueroa, G. Serino, and X. W. Deng
Role of the MPN Subunits in COP9 Signalosome Assembly and Activity, and Their Regulatory Interaction with Arabidopsis Cullin3-Based E3 Ligases
PLANT CELL, February 1, 2007; 19(2): 564 - 581.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Denti, M. E. Fernandez-Sanchez, L. Rogge, and E. Bianchi
The COP9 Signalosome Regulates Skp2 Levels and Proliferation of Human Cells
J. Biol. Chem., October 27, 2006; 281(43): 32188 - 32196.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Bornstein, D. Ganoth, and A. Hershko
Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate
PNAS, August 1, 2006; 103(31): 11515 - 11520.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Luo, Y. Wang, T. Hanck, R. Stricker, and G. Reiser
Jab1, a Novel Protease-activated Receptor-2 (PAR-2)-interacting Protein, Is Involved in PAR-2-induced Activation of Activator Protein-1
J. Biol. Chem., March 24, 2006; 281(12): 7927 - 7936.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
K. S. Richardson and W. Zundel
The Emerging Role of the COP9 Signalosome in Cancer
Mol. Cancer Res., December 1, 2005; 3(12): 645 - 653.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Verbsky and P. W. Majerus
Increased Levels of Inositol Hexakisphosphate (InsP6) Protect HEK293 Cells from Tumor Necrosis Factor {alpha}- and Fas-induced Apoptosis
J. Biol. Chem., August 12, 2005; 280(32): 29263 - 29268.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
E. M.N. Dohmann, C. Kuhnle, and C. Schwechheimer
Loss of the CONSTITUTIVE PHOTOMORPHOGENIC9 Signalosome Subunit 5 Is Sufficient to Cause the cop/det/fus Mutant Phenotype in Arabidopsis
PLANT CELL, July 1, 2005; 17(7): 1967 - 1978.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. K. Banda, C. Guthridge, D. Sheppard, K. S. Cairns, M. Muggli, D. Bech-Otschir, W. Dubiel, and W. P. Arend
Intracellular IL-1 Receptor Antagonist Type 1 Inhibits IL-1-Induced Cytokine Production in Keratinocytes through Binding to the Third Component of the COP9 Signalosome
J. Immunol., March 15, 2005; 174(6): 3608 - 3616.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Tomoda, J.-y. Kato, E. Tatsumi, T. Takahashi, Y. Matsuo, and N. Yoneda-Kato
The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression
Blood, January 15, 2005; 105(2): 775 - 783.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Dong, L. Sui, Y. Watanabe, F. Yamaguchi, N. Hatano, and M. Tokuda
Prognostic Significance of Jab1 Expression in Laryngeal Squamous Cell Carcinomas
Clin. Cancer Res., January 1, 2005; 11(1): 259 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
G. Gusmaroli, S. Feng, and X. W. Deng
The Arabidopsis CSN5A and CSN5B Subunits Are Present in Distinct COP9 Signalosome Complexes, and Mutations in Their JAMM Domains Exhibit Differential Dominant Negative Effects on Development
PLANT CELL, November 1, 2004; 16(11): 2984 - 3001.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. May, S. E. Larsen, J. H. Shim, L. A. Madge, and S. Ghosh
A Novel Ubiquitin-like Domain in I{kappa}B Kinase {beta} Is Required for Functional Activity of the Kinase
J. Biol. Chem., October 29, 2004; 279(44): 45528 - 45539.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Tomoda, N. Yoneda-Kato, A. Fukumoto, S. Yamanaka, and J.-y. Kato
Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice
J. Biol. Chem., October 8, 2004; 279(41): 43013 - 43018.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Yun, A. Tomida, T. Andoh, and T. Tsuruo
Interaction between Glucose-regulated Destruction Domain of DNA Topoisomerase II{alpha} and MPN Domain of Jab1/CSN5
J. Biol. Chem., July 23, 2004; 279(30): 31296 - 31303.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Bondar, A. Ponomarev, and P. Raychaudhuri
Ddb1 Is Required for the Proteolysis of the Schizosaccharomyces pombe Replication Inhibitor Spd1 during S Phase and after DNA Damage
J. Biol. Chem., March 12, 2004; 279(11): 9937 - 9943.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Chen, Y. Li, K. Wei, L. Li, W. Liu, Y. Zhu, Z. Qiu, and F. He
The Potentiation Role of Hepatopoietin on Activator Protein-1 Is Dependent on Its Sulfhydryl Oxidase Activity
J. Biol. Chem., December 5, 2003; 278(49): 49022 - 49030.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Lykke-Andersen, L. Schaefer, S. Menon, X.-W. Deng, J. B. Miller, and N. Wei
Disruption of the COP9 Signalosome Csn2 Subunit in Mice Causes Deficient Cell Proliferation, Accumulation of p53 and Cyclin E, and Early Embryonic Death
Mol. Cell. Biol., October 1, 2003; 23(19): 6790 - 6797.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Yan, K. Walz, H. Nakamura, S. Carattini-Rivera, Q. Zhao, H. Vogel, N. Wei, M. J. Justice, A. Bradley, and J. R. Lupski
COP9 Signalosome Subunit 3 Is Essential for Maintenance of Cell Proliferation in the Mouse Embryonic Epiblast
Mol. Cell. Biol., October 1, 2003; 23(19): 6798 - 6808.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
V. Marsaud, A. Gougelet, S. Maillard, and J.-M. Renoir
Various Phosphorylation Pathways, Depending on Agonist and Antagonist Binding to Endogenous Estrogen Receptor {alpha} (ER{alpha}), Differentially Affect ER{alpha} Extractability, Proteasome-Mediated Stability, and Transcriptional Activity in Human Breast Cancer Cells
Mol. Endocrinol., October 1, 2003; 17(10): 2013 - 2027.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. A. Kouvaraki, G. Z. Rassidakis, L. Tian, R. Kumar, C. Kittas, and F.-X. Claret
Jun Activation Domain-binding Protein 1 Expression in Breast Cancer Inversely Correlates with the Cell Cycle Inhibitor p27Kip1
Cancer Res., June 1, 2003; 63(11): 2977 - 2981.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
K. Sudre, C. Leroux, G. Pietu, I. Cassar-Malek, E. Petit, A. Listrat, C. Auffray, B. Picard, P. Martin, and J.-F. Hocquette
Transcriptome Analysis of Two Bovine Muscles during Ontogenesis
J. Biochem., June 1, 2003; 133(6): 745 - 756.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Bianchi, S. Denti, R. Catena, G. Rossetti, S. Polo, S. Gasparian, S. Putignano, L. Rogge, and R. Pardi
Characterization of Human Constitutive Photomorphogenesis Protein 1, a RING Finger Ubiquitin Ligase That Interacts with Jun Transcription Factors and Modulates Their Transcriptional Activity
J. Biol. Chem., May 23, 2003; 278(22): 19682 - 19690.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. Liu, K. A. Powell, K. Mundt, L. Wu, A. M. Carr, and T. Caspari
Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms
Genes & Dev., May 1, 2003; 17(9): 1130 - 1140.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
S. Feng, L. Ma, X. Wang, D. Xie, S. P. Dinesh-Kumar, N. Wei, and X. W. Deng
The COP9 Signalosome Interacts Physically with SCFCOI1 and Modulates Jasmonate Responses
PLANT CELL, May 1, 2003; 15(5): 1083 - 1094.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
E. D. Emberley, Y. Niu, E. Leygue, L. Tomes, R. D. Gietz, L. C. Murphy, and P. H. Watson
Psoriasin Interacts with Jab1 and Influences Breast Cancer Progression
Cancer Res., April 15, 2003; 63(8): 1954 - 1961.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Akiyama, N. Fujisawa, Y. Tashiro, N. Takanabe, A. Sugiyama, and F. Tashiro
The Role of Transcriptional Corepressor Nif3l1 in Early Stage of Neural Differentiation via Cooperation with Trip15/CSN2
J. Biol. Chem., March 14, 2003; 278(12): 10752 - 10762.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
N. A. Eckardt
Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome
PLANT CELL, March 1, 2003; 15(3): 580 - 581.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Sun, M. P. Wilson, and P. W. Majerus
Inositol 1,3,4-Trisphosphate 5/6-Kinase Associates with the COP9 Signalosome by Binding to CSN1
J. Biol. Chem., November 22, 2002; 277(48): 45759 - 45764.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Korbonits, H. S. Chahal, G. Kaltsas, S. Jordan, Y. Urmanova, Z. Khalimova, P. E. Harris, W. E. Farrell, F.-X. Claret, and A. B. Grossman
Expression of Phosphorylated p27Kip1 Protein and Jun Activation Domain-Binding Protein 1 in Human Pituitary Tumors
J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2635 - 2643.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. H. Glickman and A. Ciechanover
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
Physiol Rev, April 1, 2002; 82(2): 373 - 428.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Dawson, S. Apcher, M. Mee, H. Higashitsuji, R. Baker, S. Uhle, W. Dubiel, J. Fujita, and R. J. Mayer
Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome
J. Biol. Chem., March 22, 2002; 277(13): 10893 - 10902.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Doronkin, I. Djagaeva, and S. K. Beckendorf
CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint
Development, January 11, 2002; 129(21): 5053 - 5064.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-K. Bae, M.-Y. Ahn, J.-W. Jeong, M.-H. Bae, Y. M. Lee, S.-K. Bae, J.-W. Park, K.-R. Kim, and K.-W. Kim
Jab1 Interacts Directly with HIF-1alpha and Regulates Its Stability
J. Biol. Chem., January 4, 2002; 277(1): 9 - 12.
[Abstract] [Full Text]

Home page
 J. Cell Sci.Home page
D. Bech-Otschir, M. Seeger, and W. Dubiel
The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis
J. Cell Sci., January 2, 2002; 115(3): 467 - 473.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Pollmann, X. Huang, J. Mall, D. Bech-Otschir, M. Naumann, and W. Dubiel
The Constitutive Photomorphogenesis 9 Signalosome Directs Vascular Endothelial Growth Factor Production in Tumor Cells
Cancer Res., December 1, 2001; 61(23): 8416 - 8421.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Sui, Y. Dong, M. Ohno, Y. Watanabe, K. Sugimoto, Y. Tai, and M. Tokuda
Jab1 Expression Is Associated with Inverse Expression of p27kip1 and Poor Prognosis in Epithelial Ovarian Tumors
Clin. Cancer Res., December 1, 2001; 7(12): 4130 - 4135.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Z. Peng, G. Serino, and X.-W. Deng
A role of Arabidopsis COP9 signalosome in multifaceted developmental processes revealed by the characterization of its subunit 3
Development, November 1, 2001; 128(21): 4277 - 4288.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
Z. Peng, G. Serino, and X.-W. Deng
Molecular Characterization of Subunit 6 of the COP9 Signalosome and Its Role in Multifaceted Developmental Processes in Arabidopsis
PLANT CELL, November 1, 2001; 13(11): 2393 - 2407.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Z. Peng, J. M. Staub, G. Serino, S. F. Kwok, J. Kurepa, B. D. Bruce, R. D. Vierstra, N. Wei, and X.-W. Deng
The Cellular Level of PR500, a Protein Complex Related to the 19S Regulatory Particle of the Proteasome, Is Regulated in Response to Stresses in Plants
Mol. Biol. Cell, February 1, 2001; 12(2): 383 - 392.
[Abstract] [Full Text]

Home page
 Plant Physiol.Home page
C. S. Hardtke and X.-W. Deng
The Cell Biology of the COP/DET/FUS Proteins. Regulating Proteolysis in Photomorphogenesis and Beyond?
Plant Physiology, December 1, 2000; 124(4): 1548 - 1557.
[Full Text]

Home page
 Plant CellHome page
J. A. Sullivan and J. C. Gray
The Pea light-independent photomorphogenesis1 Mutant Results from Partial Duplication of COP1 Generating an Internal Promoter and Producing Two Distinct Transcripts
PLANT CELL, October 1, 2000; 12(10): 1927 - 1938.
[Abstract] [Full Text]

Home page
 J. Cell Biol.Home page
M. V. Gonzalez, B. Jimenez, M. T. Berciano, J. M. Gonzalez-Sancho, C. Caelles, M. Lafarga, and A. Munoz
Glucocorticoids Antagonize AP-1 by Inhibiting the Activation/Phosphorylation of JNK Without Affecting its Subcellular Distribution
J. Cell Biol., September 5, 2000; 150(5): 1199 - 1208.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Li, X. Liu, and M. Ascoli
p38JAB1 Binds to the Intracellular Precursor of the Lutropin/Choriogonadotropin Receptor and Promotes Its Degradation
J. Biol. Chem., April 28, 2000; 275(18): 13386 - 13393.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Chauchereau, M. Georgiakaki, M. Perrin-Wolff, E. Milgrom, and H. Loosfelt
JAB1 Interacts with Both the Progesterone Receptor and SRC-1
J. Biol. Chem., March 17, 2000; 275(12): 8540 - 8548.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Gorbea, D. Taillandier, and M. Rechsteiner
Mapping Subunit Contacts in the Regulatory Complex of the 26 S Proteasome. S2 AND S5b FORM A TETRAMER WITH ATPase SUBUNITS S4 and S7
J. Biol. Chem., January 14, 2000; 275(2): 875 - 882.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Naumann, D. Bech-Otschir, X. Huang, K. Ferrell, and W. Dubiel
COP9 Signalosome-directed c-Jun Activation/Stabilization Is Independent of JNK
J. Biol. Chem., December 10, 1999; 274(50): 35297 - 35300.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
G. Serino, T. Tsuge, S. Kwok, M. Matsui, N. Wei, and X.-W. Deng
Arabidopsis cop8 and fus4 Mutations Define the Same Gene That Encodes Subunit 4 of the COP9 Signalosome
PLANT CELL, October 1, 1999; 11(10): 1967 - 1980.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
P. Zwickl, D. Ng, K. M. Woo, H.-P. Klenk, and A. L. Goldberg
An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes
J. Biol. Chem., September 10, 1999; 274(37): 26008 - 26014.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
B. Karniol, P. Malec, and D. A. Chamovitz
Arabidopsis FUSCA5 Encodes a Novel Phosphoprotein That Is a Component of the COP9 Complex
PLANT CELL, May 1, 1999; 11(5): 839 - 848.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. Sakurai, H. Miyoshi, W. Toriumi, and T. Sugita
Functional Interactions of Transforming Growth Factor beta -activated Kinase 1 with Ikappa B Kinases to Stimulate NF-kappa B Activation
J. Biol. Chem., April 9, 1999; 274(15): 10641 - 10648.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
M. G. Stacey, S. N. Hicks, and A. G. von Arnim
Discrete Domains Mediate the Light-Responsive Nuclear and Cytoplasmic Localization of Arabidopsis COP1
PLANT CELL, March 1, 1999; 11(3): 349 - 364.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C Morris-Desbois, V Bochard, C Reynaud, and P Jalinot
Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies
J. Cell Sci., January 10, 1999; 112(19): 3331 - 3342.
[Abstract] [PDF]

Home page
 Plant CellHome page
S. F. Kwok, R. Solano, T. Tsuge, D. A. Chamovitz, J. R. Ecker, M. Matsui, and X.-W. Deng
Arabidopsis Homologs of a c-Jun Coactivator Are Present Both in Monomeric Form and in the COP9 Complex, and Their Abundance Is Differentially Affected by the Pleiotropic cop/det/fus Mutations
PLANT CELL, November 1, 1998; 10(11): 1779 - 1790.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Penney, C. Wilkinson, M. Wallace, J.-P. Javerzat, K. Ferrell, M. Seeger, W. Dubiel, S. McKay, R. Allshire, and C. Gordon
The pad1+ Gene Encodes a Subunit of the 26 S Proteasome in Fission Yeast
J. Biol. Chem., September 11, 1998; 273(37): 23938 - 23945.
[Abstract] [Full Text] [PDF]
<