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A synthetic model of intra-Golgi traffic

^a Laboratory of Molecular Neurobiology, Mario Negri Sud Institute, Chieti, Italy

We present a hypothesis on the mechanisms used by cells to transport cargo through the secretory system. We propose that at least three basic processes coordinately participate in membrane traffic: cisternal maturation–progression, controlled cargo diffusion along transient membrane continuities between different compartments, and a mostly retrograde vesicle-mediated transport. A ‘synthetic’ model based on the combination of these mechanisms can explain both the progression of supramolecular aggregates through the secretory pathway and the fast intra-Golgi transport of conventional cargoes. Analysis of the existing literature shows that the available data are consistent with the proposed model.—Mironov, A., Jr., Luini, A., Mironov, A. A synthetic model of intra-Golgi traffic. FASEB J. 12, 249–252 (1998)

Key Words: intra-Golgi transport • cistern maturation • lateral diffusion • Golgi enzyme recycling

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