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(The FASEB Journal. 1998;12:243-248.)
© 1998 FASEB

Nutrient–gene interactions determine mitochondrial function: effect of dietary fat

Moon-Jeong Chang Kim1,a and Carolyn D. Berdaniera,2

a Department of Foods and Nutrition, University of Georgia, Athens, Georgia 30602–3622, USA

The effect on mitochondrial respiration of feeding hydrogenated coconut oil, corn oil, or menhaden oil (MO) to diabetes-prone BHE/cdb rats and normal Sprague Dawley (SD) rats was studied. Both fat source and strain affected the temperature dependence of succinate-supported respiration. The transition temperature was greater in BHE/cdb rats than in the SD rats. The efficiency of ATP synthesis as reflected by the ADP:O ratio was decreased in the BHE/cdb rats compared to SD rats, with the exception of the comparison made at 37°C with the MO-fed rats; at this temperature, the ADP:O ratios were similar. The diet and strain differences suggest a dietary lipid–gene interaction with respect to the mobility of subunit 6 of the F1F0ATPase. This subunit has two errors in its gene: one that affects the proton channel and another that likely affects its mobility within the inner mitochondrial membrane.—Kim, M.-J. C., Berdanier, C. D. Nutrient–gene interactions determine mitochondrial function: effect of dietary fat. FASEB J. 12, 243–248 (1998)


Key Words: dietary fat saturation • Arrhenius plot • mitochondrial respiration • BHE/cdb rats




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