| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
RIIIB (CD16) and CD11b in response to inflammatory microcrystals
a Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUL
b Departments of Medicine and Physiology, Faculty of Medicine, Laval University, Ste-Foy, Québec, G1V 4G2, Canada
The inflammatory reaction associated with the deposition of monosodium urate (MSU) crystals in synovial spaces is known to be due to interactions with polymorphonuclear neutrophils mediated by presently unidentified surface structures. In this study, we have observed that antibodies directed against CD16 (VIFcRIII) and CD11b (VIM12) selectively and potently inhibit the activation of neutrophils by MSU crystals. The responses affected include the stimulation of tyrosine phosphorylation, activation of the tyrosine kinase syk, tyrosine phosphorylation of the proto-oncogene Cbl, mobilization of calcium, and stimulation of the activity of phospholipase D and of the production of superoxide anions. Tyrosine phosphorylation responses to MSU crystals develop during the Me2SO4-induced differentiation of HL-60 cells in parallel with the surface expression of CD16. These data strongly support the hypothesis that inflammatory microcrystals interact opportunistically with CD16 initially, and that the signal transduction pathways activated thereby depend on CD11b. An examination of the relevance of the hypothesis that an uncontrolled activation of CD16/CD11b may play a role in inflammatory reactions associated with a dysregulation of neutrophil function (other than crystal arthropathies) appears warranted on the basis of the present results.—Barabé, F., Gilbert, C., Liao, N., Bourgoin, S. G., Naccache, P. H. Crystal-induced neutrophil activation: involvement of Fc
RIIIB (CD16) in response to inflammatory microcrystals. FASEB J. 12, 209–220 (1998)
Key Words: tyrosine phosphorylation • inflammation • gout • signal transduction • opsonin receptors
This article has been cited by other articles:
|
|
 |
|
  H K Ea, V Monceau, E Camors, M Cohen-Solal, D Charlemagne, and F Liote Annexin 5 overexpression increased articular chondrocyte apoptosis induced by basic calcium phosphate crystals Ann Rheum Dis, November 1, 2008; 67(11): 1617 - 1625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Popa-Nita, E. Rollet-Labelle, N. Thibault, C. Gilbert, S. G. Bourgoin, and P. H. Naccache Crystal-induced neutrophil activation. IX. Syk-dependent activation of class Ia phosphatidylinositol 3-kinase J. Leukoc. Biol., September 1, 2007; 82(3): 763 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Scott, H. Ma, S. Viriyakosol, R. Terkeltaub, and R. Liu-Bryan Engagement of CD14 Mediates the Inflammatory Potential of Monosodium Urate Crystals J. Immunol., November 1, 2006; 177(9): 6370 - 6378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. K. Choi, D. B. Mount, and A. M. Reginato Pathogenesis of Gout Ann Intern Med, October 4, 2005; 143(7): 499 - 516. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Dalbeth and D. O. Haskard Mechanisms of inflammation in gout Rheumatology, September 1, 2005; 44(9): 1090 - 1096. [Full Text] [PDF]
|
|
|
|
|
|
R. Liu-Bryan, K. Pritzker, G. S. Firestein, and R. Terkeltaub TLR2 Signaling in Chondrocytes Drives Calcium Pyrophosphate Dihydrate and Monosodium Urate Crystal-Induced Nitric Oxide Generation J. Immunol., April 15, 2005; 174(8): 5016 - 5023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ryckman, C. Gilbert, R. de Medicis, A. Lussier, K. Vandal, and P. A. Tessier Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils J. Leukoc. Biol., August 1, 2004; 76(2): 433 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ratthe and D. Girard Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15R{alpha} chain J. Leukoc. Biol., July 1, 2004; 76(1): 162 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Barabe, E. Rollet-Labelle, C. Gilbert, M. J. G. Fernandes, S. N. Naccache, and P. H. Naccache Early Events in the Activation of Fc{gamma}RIIA in Human Neutrophils: Stimulated Insolubilization, Translocation to Detergent-Resistant Domains, and Degradation of Fc{gamma}RIIA J. Immunol., April 15, 2002; 168(8): 4042 - 4049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Liu, K. Aupperle, and R. Terkeltaub Src family protein tyrosine kinase signaling mediates monosodium urate crystal-induced IL-8 expression by monocytic THP-1 cells J. Leukoc. Biol., December 1, 2001; 70(6): 961 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Desaulniers, M. Fernandes, C. Gilbert, S. G. Bourgoin, and P. H. Naccache Crystal-induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals J. Leukoc. Biol., October 1, 2001; 70(4): 659 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gilbert, F. Barabe, E. Rollet-Labelle, S. G. Bourgoin, S. R. McColl, B. B. Damaj, and P. H. Naccache Evidence for a Role for SAM68 in the Responses of Human Neutrophils to Ligation of CD32 and to Monosodium Urate Crystals J. Immunol., April 1, 2001; 166(7): 4664 - 4671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. N. Serhan, I. M. Fierro, N. Chiang, and M. Pouliot Cutting Edge: Nociceptin Stimulates Neutrophil Chemotaxis and Recruitment: Inhibition by Aspirin-Triggered-15-Epi-Lipoxin A4 J. Immunol., March 15, 2001; 166(6): 3650 - 3654. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
