FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Crist, G. H.
Right arrow Articles by Lang, C. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Crist, G. H.
Right arrow Articles by Lang, C. H.
(The FASEB Journal. 1998;12:1301-1308.)
© 1998 FASEB

RESEARCH COMMUNICATION

Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats

George H. Crista, Baiyang Xua, Kathryn F. Lanouea, and Charles H. Langa,1

a Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033–0850, USA

Previous studies have shown that treatment of obese Zucker rats with the adenosine receptor antagonist 1,3-dipropyl-8-(p-acrylic) phenyl xanthine (BWA1433) improves intraperitoneal glucose tolerance. In this study, a euglycemic hyperinsulinemic clamp was performed on obese (fa/fa) and lean (Fa/fa) Zucker rats that had been treated orally with BWA1433 or vehicle for 1 wk. A constant infusion of [3H]glucose was initiated in fasted animals to measure basal whole body glucose kinetics. No differences in glucose concentration or rates of glucose production/disappearance were observed between lean or obese animals with or without BWA1433. During the euglycemic hyperinsulinemic clamp, whole body glucose disposal in obese Zucker rats was only 22% of that observed in lean animals. BWA1433 treatment increased glucose disposal by 88% in obese Zucker rats. At the end of the clamp, [14C]-2-deoxyglucose was injected to determine tissue-specific differences in glucose uptake. Gastrocnemius, soleus, heart, and liver of untreated obese animals had significantly lower glucose uptake than lean controls under hyperinsulinemic conditions. BWA1433 treatment of obese animals increased glucose uptake in gastrocnemius and soleus muscles by 44 and 47%, respectively. Conversely, BWA1433 treatment decreased glucose uptake in adipose tissue by 54 and 49% in obese and lean Zucker rats, respectively. In summary, BWA1433 improves glucose tolerance by increasing glucose uptake in skeletal muscle while decreasing glucose uptake by adipose tissue. This study suggests that insulin resistance in obese Zucker rats is tissue specific and that signaling from adenosine receptors may be a factor contributing to tissue-specific insulin resistance.—Crist, G. H., Xu, B., LaNoue, K. F., Lang, C. H. Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats. FASEB J. 12, 1301–1308 (1998)


Key Words: obesity • euglycemic hyperinsulinemic clamp • 2-deoxyglucose • glucose disposal • insulin resistance • muscle • adipose tissue




This article has been cited by other articles:


Home page
 Diabetes CareHome page
J. D. Lane, M. N. Feinglos, and R. S. Surwit
Caffeine Increases Ambulatory Glucose and Postprandial Responses in Coffee Drinkers With Type 2 Diabetes
Diabetes Care, February 1, 2008; 31(2): 221 - 222.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. Battram, J. Bugaresti, J. Gusba, and T. E. Graham
Acute caffeine ingestion does not impair glucose tolerance in persons with tetraplegia
J Appl Physiol, January 1, 2007; 102(1): 374 - 381.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. S. Battram, T. E. Graham, E. A. Richter, and F. Dela
The effect of caffeine on glucose kinetics in humans - influence of adrenaline
J. Physiol., November 15, 2005; 569(1): 347 - 355.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. Battram, J. Shearer, D. Robinson, and T. E. Graham
Caffeine ingestion does not impede the resynthesis of proglycogen and macroglycogen after prolonged exercise and carbohydrate supplementation in humans
J Appl Physiol, March 1, 2004; 96(3): 943 - 950.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. G. Wallis, C. M. Wheatley, S. Rattigan, E. J. Barrett, A. D.H. Clark, and M. G. Clark
Insulin-Mediated Hemodynamic Changes Are Impaired in Muscle of Zucker Obese Rats
Diabetes, December 1, 2002; 51(12): 3492 - 3498.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
G. B. Keijzers, B. E. De Galan, C. J. Tack, and P. Smits
Caffeine Can Decrease Insulin Sensitivity in Humans
Diabetes Care, February 1, 2002; 25(2): 364 - 369.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
F. Greer, R. Hudson, R. Ross, and T. Graham
Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans
Diabetes, October 1, 2001; 50(10): 2349 - 2354.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
G. FRUHBECK, J. GOMEZ-AMBROSI, and J. SALVADOR
Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes
FASEB J, February 1, 2001; 15(2): 333 - 340.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by The Federation of American Societies for Experimental Biology.