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a Frank Porter Graham Child Development Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-8180, USA
b Department of Medical Oncology, City of Hope Medical Center, Duarte, California 91010, USA
c Institute of Chemical Toxicology, Wayne State University, Detroit, Michigan 48201, USA
Glutathione peroxidase 1 (GPX-1) is a selenium-dependent enzyme with antioxidant properties. Previous investigations determined that mice deficient in selenium developed myocarditis when infected with a benign strain of coxsackievirus B3 (CVB3/0). To determine whether this effect was mediated by GPX-1, mice with a disrupted Gpx1 gene (Gpx1-/-) were infected with CVB3/0. Gpx1-/- mice developed myocarditis after CVB3/0 infection, whereas infected wild-type mice (Gpx1+/+) were resistant. Sequencing of viruses recovered from Gpx1-/--infected mice demonstrated seven nucleotide changes in the viral genome, of which three occurred at the G residue, the most easily oxidized base. No changes were found in virus isolated from Gpx1+/+ mice. These results demonstrate that GPX-1 provides protection against viral-induced damage in vivo due to mutations in the viral genome of a benign virus.—Beck, M. A., Esworthy, R. S., Ho, Y.-S., Chu, F.-F. Glutathione peroxidase protects mice from viral-induced myocarditis. FASEB J. 12, 1143–1149 (1998)
Key Words: selenium • GPX-1 • malondialdehyde • virus titer • cardiac pathology
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