FASEB J. Uncover Your Biological Pathway
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dubois, R. N.
Right arrow Articles by Lipsky, P. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dubois, R. N.
Right arrow Articles by Lipsky, P. E.
(The FASEB Journal. 1998;12:1063-1073.)
© 1998 FASEB

Cyclooxygenase in biology and disease

Raymond N. Duboisa,1, Steven B. Abramsonb, Leslie Croffordc, Rajnish A. Guptaa, Lee S. Simond, Leo B. A. Van De Puttee and Peter E. Lipskyf

a Departments of Medicine/GI & Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
b Department of Rheumatology, New York University School of Medicine, Hospital for Joint Diseases, New York, New York 10003, USA
c Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI 48109-0680
d Division of Rheumatology, Harvard Medical School, Beth Israel Deaconness Medical Center, Boston, Massachusetts 02215, USA
e Division of Rheumatology, University Hospital Nijmegen. 6500 HB Nijmegen, The Netherlands
f Rheumatic Diseases Division, Harold C. Simmons Arthritis Research Center, The University of Texas Southwestern Medical Center at Dallas, Texas 75235-8884, USA

Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. In the past decade, however, more progress has been made in understanding the role of cyclooxygenase enzymes in biology and disease than at any other time in history. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Here, we summarize the current understanding of the role of cyclooxygenase-1 and -2 in different physiological situations and disease processes ranging from inflammation to cancer. We have attempted to include all of the most relevant material in the field, but due to the rapid progress in this area of research we apologize that certain recent findings may have been left out.—DuBois, R. N., Abramson, S. B., Crofford, L., Gupta, R. A., Simon, L. S., van de Putte, L. B. A., Lipsky, P. E. Cyclooxygenase in biology and disease. FASEB J. 12, 1063–1073 (1998)


Key Words: Prostaglandins • Inflammation




This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
M. Sahin, E. Sahin, and S. Gumuslu
Cyclooxygenase-2 in Cancer and Angiogenesis
Angiology, April 1, 2009; 60(2): 242 - 253.
[Abstract] [PDF]

Home page
 Biol. Reprod.Home page
H.-Y. Lee, T. J. Acosta, D. J. Skarzynski, and K. Okuda
Prostaglandin F2alpha Stimulates 11Beta-Hydroxysteroid Dehydrogenase 1 Enzyme Bioactivity and Protein Expression in Bovine Endometrial Stromal Cells
Biol Reprod, April 1, 2009; 80(4): 657 - 664.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. L Novak, W. Billich, S. M. Smith, K. B. Sukhija, T. J. McLoughlin, T. A. Hornberger, and T. J. Koh
COX-2 inhibitor reduces skeletal muscle hypertrophy in mice
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1132 - R1139.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
C. A. Rouzer and L. J. Marnett
Cyclooxygenases: structural and functional insights
J. Lipid Res., April 1, 2009; 50(Supplement): S29 - S34.
[Abstract] [Full Text] [PDF]

Home page
 Acta Biochim Biophys SinHome page
X. Guo, Y. Chen, Z. Xu, Z. Xu, Y. Qian, and X. Yu
Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer
Acta Biochim Biophys Sin, March 1, 2009; 41(3): 217 - 222.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Jiang, X. Yin, M. A. Lill, M. L. Danielson, H. Freiser, and J. Huang
Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases
PNAS, December 23, 2008; 105(51): 20464 - 20469.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Prevention ResearchHome page
N. J. Kang, K. W. Lee, J. Y. Kwon, M. K. Hwang, E. A. Rogozin, Y.-S. Heo, A. M. Bode, H. J. Lee, and Z. Dong
Delphinidin Attenuates Neoplastic Transformation in JB6 Cl41 Mouse Epidermal Cells by Blocking Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling
Cancer Prevention Research, December 1, 2008; 1(7): 522 - 531.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Okamura, Y. Takano, N. Hiramatsu, K. Hayakawa, J. Yao, A. W. Paton, J. C. Paton, and M. Kitamura
Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response
Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1495 - F1503.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
L. Yu, W. K. K. Wu, Z. J. Li, H. P. S. Wong, E. K. K. Tai, H. T. Li, Y. C. Wu, and C. H. Cho
E Series of Prostaglandin Receptor 2-Mediated Activation of Extracellular Signal-Regulated Kinase/Activator Protein-1 Signaling Is Required for the Mitogenic Action of Prostaglandin E2 in Esophageal Squamous-Cell Carcinoma
J. Pharmacol. Exp. Ther., October 1, 2008; 327(1): 258 - 267.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Zhang and C. Chen
Endocannabinoid 2-Arachidonoylglycerol Protects Neurons by Limiting COX-2 Elevation
J. Biol. Chem., August 15, 2008; 283(33): 22601 - 22611.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
C.-C. Ho, Y.-C. Ling, L. W. Chang, H.-T. Tsai, M.-H. Tsai, and P. Lin
17-Beta Estradiol and Hydroxyestradiols Interact via the NF-Kappa B Pathway to Elevate Cyclooxygenase 2 Expression and Prostaglandin E2 Secretion in Human Bronchial Epithelial Cells
Toxicol. Sci., August 1, 2008; 104(2): 294 - 302.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
T. Bryn, S. Yaqub, M. Mahic, K. Henjum, E. M. Aandahl, and K. Tasken
LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism
Int. Immunol., February 1, 2008; 20(2): 235 - 245.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y.-S. Piao, Y.-C. Du, H. Oshima, J.-C. Jin, M. Nomura, T. Yoshimoto, and M. Oshima
Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency
Carcinogenesis, February 1, 2008; 29(2): 440 - 447.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J.-Y. Qian, P. Harding, Y. Liu, E. Shesely, X.-P. Yang, and M. C. LaPointe
Reduced Cardiac Remodeling and Function in Cardiac-Specific EP4 Receptor Knockout Mice With Myocardial Infarction
Hypertension, February 1, 2008; 51(2): 560 - 566.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. K. Sackett, I. Bairati, F. Meyer, E. Jobin, S. Lussier, A. Fortin, M. Gelinas, A. Nabid, F. Brochet, and B. Tetu
Prognostic Significance of Cyclooxygenase-2 Overexpression in Glottic Cancer
Clin. Cancer Res., January 1, 2008; 14(1): 67 - 73.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
H. E. Hollingshead, M. G. Borland, A. N. Billin, T. M. Willson, F. J. Gonzalez, and J. M. Peters
Ligand activation of peroxisome proliferator-activated receptor-{beta}/{delta} (PPAR{beta}/{delta}) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms
Carcinogenesis, January 1, 2008; 29(1): 169 - 176.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Yamashita, T. Shinohara, S. Tsuji, Q. N. Myrvik, A. Nishiyama, R. A. Henriksen, and Y. Shibata
Catalytically Inactive Cyclooxygenase 2 and Absence of Prostaglandin E2 Biosynthesis in Murine Peritoneal Macrophages following In Vivo Phagocytosis of Heat-Killed Mycobacterium bovis Bacillus Calmette-Guerin
J. Immunol., November 15, 2007; 179(10): 7072 - 7078.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. G. Izzo and J. A. Ajani
Thinking In and Out of the Box When It Comes to Gastric Cancer and Cyclooxygenase-2
J. Clin. Oncol., November 1, 2007; 25(31): 4865 - 4867.
[Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J. M. Siegfried, C. T. Gubish, M. E. Rothstein, P. E. Q. de Oliveira, and L. P. Stabile
Signaling Pathways Involved in Cyclooxygenase-2 Induction by Hepatocyte Growth Factor in Non Small-Cell Lung Cancer
Mol. Pharmacol., September 1, 2007; 72(3): 769 - 779.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
W. W. Polk, M. E. Ellis, J. V. Kushleika, P. L. Simmonds, and J. S. Woods
RhoA regulation of NF-{kappa}B activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells
Am J Physiol Cell Physiol, September 1, 2007; 293(3): C1160 - C1170.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. Hasegawa, Y. Yamada, K. Komiyama, M. Hayashi, M. Ishibashi, T. Sunazuka, T. Izuhara, K. Sugahara, K. Tsuruda, M. Masuda, et al.
A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-{Delta}12, 14 prostaglandin J2 production
Blood, September 1, 2007; 110(5): 1664 - 1674.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Joo, M. Kwon, R. T. Sadikot, P. J. Kingsley, L. J. Marnett, T. S. Blackwell, R. S. Peebles Jr, Y. Urade, and J. W. Christman
Induction and Function of Lipocalin Prostaglandin D Synthase in Host Immunity
J. Immunol., August 15, 2007; 179(4): 2565 - 2575.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. S.J. Yeoh, R. J. Gibson, E. E.K. Yeoh, J. M. Bowen, A. M. Stringer, K. A. Giam, and D. M.K. Keefe
A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-{kappa}B, COX-1, and COX-2
Mol. Cancer Ther., August 1, 2007; 6(8): 2319 - 2327.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. Donnini, F. Finetti, R. Solito, E. Terzuoli, A. Sacchetti, L. Morbidelli, P. Patrignani, and M. Ziche
EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways
FASEB J, August 1, 2007; 21(10): 2418 - 2430.
[Abstract] [Full Text] [PDF]

Home page
 jvdiHome page
K. M. Rassnick and B. L. Njaa
Cyclooxygenase-2 immunoreactivity in equine ocular squamous-cell carcinoma
J Vet Diagn Invest, July 1, 2007; 19(4): 436 - 439.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
L. W. Chang, Y.-C. Chang, C.-C. Ho, M.-H. Tsai, and P. Lin
Increase of carcinogenic risk via enhancement of cyclooxygenase-2 expression and hydroxyestradiol accumulation in human lung cells as a result of interaction between BaP and 17-beta estradiol
Carcinogenesis, July 1, 2007; 28(7): 1606 - 1612.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Yamashita, S. Tsuji, A. Nishiyama, Q. N. Myrvik, R. A. Henriksen, and Y. Shibata
Differential subcellular localization of COX-2 in macrophages phagocytosing heat-killed Mycobacterium bovis BCG
Am J Physiol Cell Physiol, July 1, 2007; 293(1): C184 - C190.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
L. S. Aroeira, A. Aguilera, J. A. Sanchez-Tomero, M. A. Bajo, G. del Peso, J. A. Jimenez-Heffernan, R. Selgas, and M. Lopez-Cabrera
Epithelial to Mesenchymal Transition and Peritoneal Membrane Failure in Peritoneal Dialysis Patients: Pathologic Significance and Potential Therapeutic Interventions
J. Am. Soc. Nephrol., July 1, 2007; 18(7): 2004 - 2013.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. S. Barbieri and B. B. Weksler
Tobacco smoke cooperates with interleukin-1{beta} to alter {beta}-catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase-2 expression in vitro and in vivo
FASEB J, June 1, 2007; 21(8): 1831 - 1843.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Y. S. Park, J. Kim, Y. Misonou, R. Takamiya, M. Takahashi, M. R. Freeman, and N. Taniguchi
Acrolein Induces Cyclooxygenase-2 and Prostaglandin Production in Human Umbilical Vein Endothelial Cells: Roles of p38 MAP Kinase
Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): 1319 - 1325.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. M. Weinheimer, B. Jemiolo, C. C. Carroll, M. P. Harber, J. M. Haus, N. A. Burd, J. K. LeMoine, S. W. Trappe, and T. A. Trappe
Resistance exercise and cyclooxygenase (COX) expression in human skeletal muscle: implications for COX-inhibiting drugs and protein synthesis
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2241 - R2248.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
O. Fantappie, M. Solazzo, N. Lasagna, F. Platini, L. Tessitore, and R. Mazzanti
P-Glycoprotein Mediates Celecoxib-Induced Apoptosis in Multiple Drug-Resistant Cell Lines
Cancer Res., May 15, 2007; 67(10): 4915 - 4923.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Joo, J. G. Wright, N. N. Hu, R. T. Sadikot, G. Y. Park, T. S. Blackwell, and J. W. Christman
Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1219 - L1226.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. Eligini, S. S. Barbieri, I. Arenaz, E. Tremoli, and S. Colli
Paracrine up-regulation of monocyte cyclooxygenase-2 by platelets: Role of transforming growth factor-{beta}1
Cardiovasc Res, May 1, 2007; 74(2): 270 - 278.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. M. Bock, S. G. Menon, L. L. Sinclair, N. S. Bedford, P. C. Goswami, F. E. Domann, and D. K. Trask
Celecoxib Toxicity Is Cell Cycle Phase Specific
Cancer Res., April 15, 2007; 67(8): 3801 - 3808.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J.-Y. Liou, D. Ghelani, S. Yeh, and K. K. Wu
Nonsteroidal Anti-inflammatory Drugs Induce Colorectal Cancer Cell Apoptosis by Suppressing 14-3-3{varepsilon}
Cancer Res., April 1, 2007; 67(7): 3185 - 3191.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
A. Hosono, U. Yamaguchi, A. Makimoto, M. Endo, A. Watanabe, T. Shimoda, M. Kaya, T. Matsumura, H. Sonobe, T. Kusumi, et al.
Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma
J. Clin. Pathol., April 1, 2007; 60(4): 410 - 414.
[Abstract] [Full Text] [PDF]

Home page
 Clin Med ResHome page
C.K.S. Ong, P. Lirk, C.H. Tan, and R.A. Seymour
An Evidence-Based Update on Nonsteroidal Anti-Inflammatory Drugs
Clin. Med. Res., March 1, 2007; 5(1): 19 - 34.
[Abstract] [Full Text] [PDF]

Home page
 J Bone Joint Surg BrHome page
M. Saudan, P. Saudan, T. Perneger, N. Riand, A. Keller, and P. Hoffmeyer
Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement: A PROSPECTIVE RANDOMISED TRIAL
J Bone Joint Surg Br, February 1, 2007; 89-B(2): 155 - 159.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
L.C. Gerstenfeld, M. Al-Ghawas, Y.M. Alkhiary, D.M. Cullinane, E.A. Krall, J.L. Fitch, E.G. Webb, M.A. Thiede, and T.A. Einhorn
Selective and Nonselective Cyclooxygenase-2 Inhibitors and Experimental Fracture-Healing. Reversibility of Effects After Short-Term Treatment
J. Bone Joint Surg. Am., January 1, 2007; 89(1): 114 - 125.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Xu, C. Han, and T. Wu
A Novel Positive Feedback Loop between Peroxisome Proliferator-activated Receptor-{delta} and Prostaglandin E2 Signaling Pathways for Human Cholangiocarcinoma Cell Growth
J. Biol. Chem., November 10, 2006; 281(45): 33982 - 33996.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
E B. Y. Konuk, O. Konuk, M. Misirlioglu, A. Menevse, and M. Unal
Expression of cyclooxygenase-2 in orbital fibroadipose connective tissues of Graves' ophthalmopathy patients.
Eur. J. Endocrinol., November 1, 2006; 155(5): 681 - 685.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
F. Cianchi, C. Cortesini, L. Magnelli, E. Fanti, L. Papucci, N. Schiavone, L. Messerini, A. Vannacci, S. Capaccioli, F. Perna, et al.
Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells.
Mol. Cancer Ther., November 1, 2006; 5(11): 2716 - 2726.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Tong, Y. Ding, and H.-H. Tai
Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells
Carcinogenesis, November 1, 2006; 27(11): 2170 - 2179.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. R. Hill, A. Papafili, H. Booth, P. Lawson, M. Hubner, H. Beynon, C. Read, G. Lindahl, R. P. Marshall, R. J. McAnulty, et al.
Functional Prostaglandin-Endoperoxide Synthase 2 Polymorphism Predicts Poor Outcome in Sarcoidosis
Am. J. Respir. Crit. Care Med., October 15, 2006; 174(8): 915 - 922.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
S. Odau, C. Gabler, C. Holder, and R. Einspanier
Differential expression of cyclooxygenase 1 and cyclooxygenase 2 in the bovine oviduct.
J. Endocrinol., October 1, 2006; 191(1): 263 - 274.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
N. Sang and C. Chen
Lipid Signaling and Synaptic Plasticity
Neuroscientist, October 1, 2006; 12(5): 425 - 434.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
H. Oshima, M. M. Taketo, and M. Oshima
Destruction of Pancreatic beta-Cells by Transgenic Induction of Prostaglandin E2 in the Islets
J. Biol. Chem., September 29, 2006; 281(39): 29330 - 29336.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. F. G. van Helden, D. J. E. B. Krooshoop, K. C. M. Broers, R. A. P. Raymakers, C. G. Figdor, and F. N. van Leeuwen
A Critical Role for Prostaglandin E2 in Podosome Dissolution and Induction of High-Speed Migration during Dendritic Cell Maturation
J. Immunol., August 1, 2006; 177(3): 1567 - 1574.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
R. A. Davies, B. Knight, Y. W. Tian, G. C.T. Yeoh, and J. K. Olynyk
Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor
Carcinogenesis, August 1, 2006; 27(8): 1607 - 1616.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
N. Sharma-Walia, H. Raghu, S. Sadagopan, R. Sivakumar, M. V. Veettil, P. P. Naranatt, M. M. Smith, and B. Chandran
Cyclooxygenase 2 Induced by Kaposi's Sarcoma-Associated Herpesvirus Early during In Vitro Infection of Target Cells Plays a Role in the Maintenance of Latent Viral Gene Expression.
J. Virol., July 1, 2006; 80(13): 6534 - 6552.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
R. Martin-Venegas, S. Roig-Perez, R. Ferrer, and J. J. Moreno
Arachidonic acid cascade and epithelial barrier function during Caco-2 cell differentiation
J. Lipid Res., July 1, 2006; 47(7): 1416 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. R. Mann, M. G. Backlund, F. G. Buchanan, T. Daikoku, V. R. Holla, D. W. Rosenberg, S. K. Dey, and R. N. DuBois
Repression of Prostaglandin Dehydrogenase by Epidermal Growth Factor and Snail Increases Prostaglandin E2 and Promotes Cancer Progression.
Cancer Res., July 1, 2006; 66(13): 6649 - 6656.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. Abdelrahim, C. H. Baker, J. L. Abbruzzese, and S. Safe
Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation.
J Natl Cancer Inst, June 21, 2006; 98(12): 855 - 868.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
J Mrena, J-P Wiksten, S Nordling, A Kokkola, A Ristimaki, and C Haglund
MMP-2 but not MMP-9 associated with COX-2 and survival in gastric cancer.
J. Clin. Pathol., June 1, 2006; 59(6): 618 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
T. G. Neilan, D. S. Jassal, M. F. Scully, G. Chen, C. Deflandre, H. McAllister, E. Kay, S. C. Austin, E. F. Halpern, J. H. Harmey, et al.
Iloprost attenuates doxorubicin-induced cardiac injury in a murine model without compromising tumour suppression
Eur. Heart J., May 2, 2006; 27(10): 1251 - 1256.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
K. P. Choe, J. Havird, R. Rose, K. Hyndman, P. Piermarini, and D. H. Evans
COX2 in a euryhaline teleost, Fundulus heteroclitus: primary sequence, distribution, localization, and potential function in gills during salinity acclimation
J. Exp. Biol., May 1, 2006; 209(9): 1696 - 1708.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
B. A. Narayanan, N. K. Narayanan, L. Davis, and D. Nargi
RNA interference-mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor
Mol. Cancer Ther., May 1, 2006; 5(5): 1117 - 1125.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
D. Wang, H. Wang, J. Brown, T. Daikoku, W. Ning, Q. Shi, A. Richmond, R. Strieter, S. K. Dey, and R. N. DuBois
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
J. Exp. Med., April 17, 2006; 203(4): 941 - 951.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Huh, A. Liepins, J. Zielonka, C. Andrekopoulos, B. Kalyanaraman, and A. Sorokin
Cyclooxygenase 2 Rescues LNCaP Prostate Cancer Cells from Sanguinarine-Induced Apoptosis by a Mechanism Involving Inhibition of Nitric Oxide Synthase Activity.
Cancer Res., April 1, 2006; 66(7): 3726 - 3736.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
B. Miller, V. A. Patel, and A. Sorokin
Cyclooxygenase-2 Rescues Rat Mesangial Cells from Apoptosis Induced by Adriamycin via Upregulation of Multidrug Resistance Protein 1 (P-Glycoprotein)
J. Am. Soc. Nephrol., April 1, 2006; 17(4): 977 - 985.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Castells, A. Paya, C. Alenda, F. Rodriguez-Moranta, R. Agrelo, M. Andreu, V. Pinol, S. Castellvi-Bel, R. Jover, X. Llor, et al.
Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency.
Clin. Cancer Res., March 15, 2006; 12(6): 1686 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Chen, H. Hwang, M. E. Rose, R. G. Nines, and G. D. Stoner
Chemopreventive Properties of Black Raspberries in N-Nitrosomethylbenzylamine-Induced Rat Esophageal Tumorigenesis: Down-regulation of Cyclooxygenase-2, Inducible Nitric Oxide Synthase, and c-Jun.
Cancer Res., March 1, 2006; 66(5): 2853 - 2859.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
R. Suzuki, H. Kohno, M. Suzui, N. Yoshimi, H. Tsuda, K. Wakabayashi, and T. Tanaka
An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies
Carcinogenesis, March 1, 2006; 27(3): 619 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. J. Tyson-Capper and G. N. Europe-Finner
Novel Targeting of Cyclooxygenase-2 (COX-2) Pre-mRNA Using Antisense Morpholino Oligonucleotides Directed to the 3' Acceptor and 5' Donor Splice Sites of Exon 4: Suppression of COX-2 Activity in Human Amnion-Derived WISH and Myometrial Cells
Mol. Pharmacol., March 1, 2006; 69(3): 796 - 804.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. D'Orazi, M. G. Sciulli, V. Di Stefano, S. Riccioni, M. Frattini, R. Falcioni, L. Bertario, A. Sacchi, and P. Patrignani
Homeodomain-Interacting Protein Kinase-2 Restrains Cytosolic Phospholipase A2-Dependent Prostaglandin E2 Generation in Human Colorectal Cancer Cells
Clin. Cancer Res., February 1, 2006; 12(3): 735 - 741.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
V. R. Babaev, L. Ding, J. Reese, J. D. Morrow, M. D. Breyer, S. K. Dey, S. Fazio, and M. F. Linton
Cyclooxygenase-1 Deficiency in Bone Marrow Cells Increases Early Atherosclerosis in Apolipoprotein E- and Low-Density Lipoprotein Receptor-Null Mice
Circulation, January 3, 2006; 113(1): 108 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. Csiki, K. Yanagisawa, N. Haruki, S. Nadaf, J. D. Morrow, D. H. Johnson, and D. P. Carbone
Thioredoxin-1 Modulates Transcription of Cyclooxygenase-2 via Hypoxia-Inducible Factor-1{alpha} in Non-Small Cell Lung Cancer
Cancer Res., January 1, 2006; 66(1): 143 - 150.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
D Wang and R N DuBois
PROSTAGLANDINS AND CANCER
Gut, January 1, 2006; 55(1): 115 - 122.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Martin, D. C. Phillips, K. Szekely-Szucs, L. Elghazi, F. Desmots, and J. A. Houghton
Cyclooxygenase-2 Inhibition Sensitizes Human Colon Carcinoma Cells to TRAIL-Induced Apoptosis through Clustering of DR5 and Concentrating Death-Inducing Signaling Complex Components into Ceramide-Enriched Caveolae
Cancer Res., December 15, 2005; 65(24): 11447 - 11458.
[Abstract] [Full Text] [PDF]

Home page
 Journal of the American Animal Hospital AssociationHome page
G. L. Carroll and S. M. Simonson
Recent Developments in Nonsteroidal Antiinflammatory Drugs in Cats
J. Am. Anim. Hosp. Assoc., November 1, 2005; 41(6): 347 - 354.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S.-p. Zhao, P. Deng, H.-g. Huang, Z.-m. Xu, H.-y. Dai, S.-c. Hong, J. Yang, and H.-n. Zhou
Expression of COX-2 mRNA in Peripheral Blood Monocytes from Patients with Acute Myocardial Infarction and Its Significance
Clin. Chem., November 1, 2005; 51(11): 2170 - 2173.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Dalwadi, K. Krysan, N. Heuze-Vourc'h, M. Dohadwala, D. Elashoff, S. Sharma, N. Cacalano, A. Lichtenstein, and S. Dubinett
Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non-Small Cell Lung Cancer
Clin. Cancer Res., November 1, 2005; 11(21): 7674 - 7682.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Sang, J. Zhang, V. Marcheselli, N. G. Bazan, and C. Chen
Postsynaptically Synthesized Prostaglandin E2 (PGE2) Modulates Hippocampal Synaptic Transmission via a Presynaptic PGE2 EP2 Receptor
J. Neurosci., October 26, 2005; 25(43): 9858 - 9870.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Ferrario, A. M. Fisher, N. Rucker, and C. J. Gomer
Celecoxib and NS-398 Enhance Photodynamic Therapy by Increasing In vitro Apoptosis and Decreasing In vivo Inflammatory and Angiogenic Factors
Cancer Res., October 15, 2005; 65(20): 9473 - 9478.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Lu and L. M. Wahl
Oxidative Stress Augments the Production of Matrix Metalloproteinase-1, Cyclooxygenase-2, and Prostaglandin E2 through Enhancement of NF-{kappa}B Activity in Lipopolysaccharide-Activated Human Primary Monocytes
J. Immunol., October 15, 2005; 175(8): 5423 - 5429.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Mrena, J.-P. Wiksten, A. Thiel, A. Kokkola, L. Pohjola, J. Lundin, S. Nordling, A. Ristimaki, and C. Haglund
Cyclooxygenase-2 Is an Independent Prognostic Factor in Gastric Cancer and Its Expression Is Regulated by the Messenger RNA Stability Factor HuR
Clin. Cancer Res., October 15, 2005; 11(20): 7362 - 7368.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
K. P. Townsend and D. Pratico
Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs
FASEB J, October 1, 2005; 19(12): 1592 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. J. Sales, T. List, S. C. Boddy, A. R.W. Williams, R. A. Anderson, Z. Naor, and H. N. Jabbour
A Novel Angiogenic Role for Prostaglandin F2{alpha}-FP Receptor Interaction in Human Endometrial Adenocarcinomas
Cancer Res., September 1, 2005; 65(17): 7707 - 7716.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Moreno, A. V. Krishnan, S. Swami, L. Nonn, D. M. Peehl, and D. Feldman
Regulation of Prostaglandin Metabolism by Calcitriol Attenuates Growth Stimulation in Prostate Cancer Cells
Cancer Res., September 1, 2005; 65(17): 7917 - 7925.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. I. Abdalla, I. R. Sanderson, and R. C. Fitzgerald
Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells
Carcinogenesis, September 1, 2005; 26(9): 1627 - 1633.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-G. Hwang, S.-S. Yu, H. Poo, and J.-S. Chun
c-Jun/Activator Protein-1 Mediates Interleukin-1{beta}-induced Dedifferentiation but Not Cyclooxygenase-2 Expression in Articular Chondrocytes
J. Biol. Chem., August 19, 2005; 280(33): 29780 - 29787.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. Pratico and J.-M. Dogne
Selective Cyclooxygenase-2 Inhibitors Development in Cardiovascular Medicine
Circulation, August 16, 2005; 112(7): 1073 - 1079.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Shi, N. L. A. Misso, D. L. Duffy, B. Bradley, R. Beard, P. J. Thompson, and M-A. Kedda
Cyclooxygenase-1 gene polymorphisms in patients with different asthma phenotypes and atopy
Eur. Respir. J., August 1, 2005; 26(2): 249 - 256.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Lantz, T. Vondrichova, H. Parikh, C. Frenander, M. Ridderstrale, P. Asman, M. Aberg, L. Groop, and B. Hallengren
Overexpression of Immediate Early Genes in Active Graves' Ophthalmopathy
J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4784 - 4791.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Krysan, K. L. Reckamp, H. Dalwadi, S. Sharma, E. Rozengurt, M. Dohadwala, and S. M. Dubinett
Prostaglandin E2 Activates Mitogen-Activated Protein Kinase/Erk Pathway Signaling and Cell Proliferation in Non-Small Cell Lung Cancer Cells in an Epidermal Growth Factor Receptor-Independent Manner
Cancer Res., July 15, 2005; 65(14): 6275 - 6281.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. B. Kilunga, T. Inoue, Y. Okano, Z. Kabututu, S. K. Martin, M. Lazarus, M. Duszenko, Y. Sumii, Y. Kusakari, H. Matsumura, et al.
Structural and Mutational Analysis of Trypanosoma brucei Prostaglandin H2 Reductase Provides Insight into the Catalytic Mechanism of Aldo-ketoreductases
J. Biol. Chem., July 15, 2005; 280(28): 26371 - 26382.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. Y. Fukuda, S. P. Lad, D. P. Mikolon, M. Iacobelli-Martinez, and E. Li
Activation of Lipid Metabolism Contributes to Interleukin-8 Production during Chlamydia trachomatis Infection of Cervical Epithelial Cells
Infect. Immun., July 1, 2005; 73(7): 4017 - 4024.
[Abstract] [Full Text] [PDF]

Home page
 J Clin PharmacolHome page
P. A. Konstantinopoulos and D. F. Lehmann
The Cardiovascular Toxicity of Selective and Nonselective Cyclooxygenase Inhibitors: Comparisons, Contrasts, and Aspirin Confounding
J. Clin. Pharmacol., July 1, 2005; 45(7): 742 - 750.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Parent and M. A. Fortier
Expression and Contribution of Three Different Isoforms of Prostaglandin E Synthase in the Bovine Endometrium
Biol Reprod, July 1, 2005; 73(1): 36 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. Dou, S. Thompson-Jaeger, S. J. F. Laulederkind, J. W. Becker, J. Montgomery, E. Ruiz-Bustos, D. L. Hasty, L. R. Ballou, P. S. Eastman, B. Srichai, et al.
Defective expression of Tamm-Horsfall protein/uromodulin in COX-2-deficient mice increases their susceptibility to urinary tract infections
Am J Physiol Renal Physiol, July 1, 2005; 289(1): F49 - F60.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Joo, Y. S. Hahn, M. Kwon, R. T. Sadikot, T. S. Blackwell, and J. W. Christman
Hepatitis C Virus Core Protein Suppresses NF-{kappa}B Activation and Cyclooxygenase-2 Expression by Direct Interaction with I{kappa}B Kinase {beta}
J. Virol., June 15, 2005; 79(12): 7648 - 7657.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Kim, S. H. Rhee, E. Kokkotou, X. Na, T. Savidge, M. P. Moyer, C. Pothoulakis, and J. T. LaMont
Clostridium difficile Toxin A Regulates Inducible Cyclooxygenase-2 and Prostaglandin E2 Synthesis in Colonocytes via Reactive Oxygen Species and Activation of p38 MAPK
J. Biol. Chem., June 3, 2005; 280(22): 21237 - 21245.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
X. Zhang and A. H. Neufeld
Activation of the Epidermal Growth Factor Receptor in Optic Nerve Astrocytes Leads to Early and Transient Induction of Cyclooxygenase-2
Invest. Ophthalmol. Vis. Sci., June 1, 2005; 46(6): 2035 - 2041.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
E. M. Sievers, R. D. Bart, L. M. Backhus, Y. Lin, M. Starnes, R. Castanos, V. A. Starnes, and Ross. M. Bremner
Evaluation of cyclooxygenase-2 inhibition in an orthotopic murine model of lung cancer for dose-dependent effect
J. Thorac. Cardiovasc. Surg., June 1, 2005; 129(6): 1242 - 1249.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
Y. Denkins, D. Kempf, M. Ferniz, S. Nileshwar, and D. Marchetti
Role of {omega}-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma
J. Lipid Res., June 1, 2005; 46(6): 1278 - 1284.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
V. Mollace, C. Muscoli, E. Masini, S. Cuzzocrea, and D. Salvemini
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Pharmacol. Rev., June 1, 2005; 57(2): 217 - 252.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
M Fornai, C Blandizzi, R Colucci, L Antonioli, N Bernardini, C Segnani, B Baragatti, S Barogi, P Berti, R Spisni, et al.
Role of cyclooxygenases 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice
Gut, May 1, 2005; 54(5): 608 - 616.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by The Federation of American Societies for Experimental Biology.