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(The FASEB Journal. 1998;12:1027-1034.)
© 1998 FASEB

RESEARCH COMMUNICATION

FGF-2 stimulates migration of Kaposi's sarcoma-like vascular cells by HGF-dependent relocalization of the urokinase receptor

Ugo Cavallaroa,1, Zhihao Wua, Andrea Di Paloa, Roberto Montesanob, Michael S. Pepperb, Jeanette A. M. maierc, and Marco R. Soriaa

a Department of Biological and Technological Research, San Raffaele Scientific Institute, Milano, Italy
b Department of Morphology, University of Geneva Medical Center, Geneva, Switzerland
c Department of Biomedical Sciences and Technologies, University of Milano, Milano, Italy

The spindle-shaped cell line TTB was recently isolated from highly vascularized skin lesions of BKV/HIV-1 tat transgenic mice and shown to possess an autocrine loop for hepatocyte growth factor (HGF). We show that fibroblast growth factor-2 (FGF-2) stimulates TTB cell migration and promotes polarization of uPAR at the leading edge of migrating cells. FGF-stimulated TTB cells presented the typical migratory phenotype, with a triangular cell shape and concomitant breakdown of actin stress fibers and smooth muscle-specific actin isoform. FGF-2-stimulated migration was blocked by antibodies against urokinase-type plasminogen activator (uPA) or uPA receptor (uPAR) and by neutralizing anti-HGF antibodies. The latter also inhibited uPAR relocalization at the cell surface of FGF-2-treated TTB cells. This points to a crosstalk between FGF-2 and HGF that might mediate TTB cell migration by modulating the localization of cell surface uPAR.—Cavallaro, U., Wu, Z., Di Palo, A., Montesano, R., Pepper, M. S., Maier, J. A. M., Soria, M. R. FGF-2 stimulates migration of Kaposi's sarcoma-like vascular cells by HGF-dependent relocalization of the urokinase receptor. FASEB J. 12, 1027–1034 (1998)


Key Words: TTB cell migration • hepatocyte growth factor • FGF • uPAR relocalization




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