Proteins that specifically recognize cisplatin-damaged DNA: a clue to anticancer activity of cisplatin

^a Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331–7305, USA
^b Institute of Genetics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
^c Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

Cisplatin, but not its trans geometric isomer, is a potent anticancer drug whose biological activity is a consequence of the formation of covalent adducts between the platinum compound and certain bases in DNA. Two classes of proteins have recently been identified that bind preferentially to damaged sites: proteins that specifically recognize those sites as a first step in their repair, and those that bind to such sites by virtue of structural similarity between the modified DNA and their own natural binding sites. Both classes of proteins may be involved, perhaps in opposing ways, in the cytotoxic effect of the drug.—Zlatanova, J., Yaneva, J., Leuba, S. H. Proteins that specifically recognize cisplatin-damaged DNA: a clue to anticancer activity of cisplatin. FASEB J. 12, 791–799 (1998)

Key Words: anticancer drugs • DNA adducts • DDP • transplatin

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