FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Loffreda, S.
Right arrow Articles by Diehl, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Loffreda, S.
Right arrow Articles by Diehl, A. M.
(The FASEB Journal. 1998;12:57-65.)
© 1998 FASEB

RESEARCH COMMUNICATION

Leptin regulates proinflammatory immune responses

S. Loffredaa, S. Q. Yanga, H. Z. Lina, C. L. Karpa,b, M. L. Brengmanc, D. J. Wangd, A. S. Kleinc, G. B. Bulkleyc, C. Baoa, P. W. Noblea, M. D. Laned, and A. M. Diehla,1

a Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
b Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland 21205, USA
c Department of Surgery, Johns Hopkins University, Baltimore, Maryland 21205, USA
d Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland 21205, USA

Obesity is associated with an increased incidence of infection, diabetes, and cardiovascular disease, which together account for most obesity-related morbidity and mortality. Decreased expression of leptin or of functional leptin receptors results in hyperphagia, decreased energy expenditure, and obesity. It is unclear, however, whether defective leptin-dependent signal transduction directly promotes any of the conditions that frequently complicate obesity. Abnormalities in tumor necrosis factor {alpha} expression have been noted in each of the above comorbid conditions, so leptin deficiency could promote these complications if leptin had immunoregulatory activity. Studies of rodents with genetic abnormalities in leptin or leptin receptors revealed obesity-related deficits in macrophage phagocytosis and the expression of proinflammatory cytokines both in vivo and in vitro. Exogenous leptin up-regulated both phagocytosis and the production of proinflammatory cytokines. These results identify an important and novel function for leptin: up-regulation of inflammatory immune responses, which may provide a common pathogenetic mechanism that contributes to several of the major complications of obesity.—Loffreda, S., Yang, S. Q., Lin, H. Z., Karp, C. L., Brengman, M. L., Wang, D. J., Klein, A. S., Bulkley, G. B., Bao, C., Noble, P. W., Lane, M. D., Diehl, A. M. Leptin regulates proinflammatory immune responses. FASEB J. 12, 57–65 (1998)


Key Words: obesity • macrophage • cytokine • phagocytic function • TNF • lipopolysaccharide




This article has been cited by other articles:


Home page
 CLIN APPL THROMB HEMOSTHome page
J. Malyszko, J.S. Malyszko, P. Kozminski, K. Pawlak, and M. Mysliwiec
Adipokines, Linking Adipocytes and Vascular Function in Hemodialyzed Patients, May Also Be Possibly Related to CD146, a Novel Adhesion Molecule
Clinical and Applied Thrombosis/Hemostasis, July 1, 2008; 14(3): 338 - 345.
[Abstract] [PDF]

Home page
 CirculationHome page
K. K. Koh, S. M. Park, and M. J. Quon
Leptin and Cardiovascular Disease: Response to Therapeutic Interventions
Circulation, June 24, 2008; 117(25): 3238 - 3249.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. A. Johnston, T. A. Theman, F. L. Lu, R. D. Terry, E. S. Williams, and S. A. Shore
Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation
J Appl Physiol, June 1, 2008; 104(6): 1727 - 1735.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Sasaki, N. Suzuki, R. Kent Jr., N. Kawashima, J. Takeda, and P. Stashenko
T Cell Response Mediated by Myeloid Cell-Derived IL-12 Is Responsible for Porphyromonas gingivalis-Induced Periodontitis in IL-10-Deficient Mice
J. Immunol., May 1, 2008; 180(9): 6193 - 6198.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. R. Kabyemela, M. Fried, J. D. Kurtis, T. K. Mutabingwa, and P. E. Duffy
Fetal Responses during Placental Malaria Modify the Risk of Low Birth Weight
Infect. Immun., April 1, 2008; 76(4): 1527 - 1534.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
Z. Veleva, A. Tiitinen, S. Vilska, C. Hyden-Granskog, C. Tomas, H. Martikainen, and J. S. Tapanainen
High and low BMI increase the risk of miscarriage after IVF/ICSI and FET
Hum. Reprod., April 1, 2008; 23(4): 878 - 884.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. K. Surmi, R. D. Atkinson, M. L. Gruen, K. R. Coenen, and A. H. Hasty
The role of macrophage leptin receptor in aortic root lesion formation
Am J Physiol Endocrinol Metab, March 1, 2008; 294(3): E488 - E495.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
E. F. M. Wouters, K. H. Groenewegen, M. A. Dentener, and J. H. J. Vernooy
Systemic Inflammation in Chronic Obstructive Pulmonary Disease: The Role of Exacerbations
Proceedings of the ATS, December 1, 2007; 4(8): 626 - 634.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. L. K. Lam, B.-J. Zheng, D.-Y. Jin, X. Cao, and L. Lu
Leptin Induces CD40 Expression through the Activation of Akt in Murine Dendritic Cells
J. Biol. Chem., September 21, 2007; 282(38): 27587 - 27597.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. Yang and L. A. Barouch
Leptin Signaling and Obesity: Cardiovascular Consequences
Circ. Res., September 14, 2007; 101(6): 545 - 559.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. Muniyappa, M. Montagnani, K. K. Koh, and M. J. Quon
Cardiovascular Actions of Insulin
Endocr. Rev., August 1, 2007; 28(5): 463 - 491.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-H. Tang, D.-Y. Lu, R.-S. Yang, H.-Y. Tsai, M.-C. Kao, W.-M. Fu, and Y.-F. Chen
Leptin-Induced IL-6 Production Is Mediated by Leptin Receptor, Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, Akt, NF-{kappa}B, and p300 Pathway in Microglia
J. Immunol., July 15, 2007; 179(2): 1292 - 1302.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Katagiri, T. Yamada, and Y. Oka
Adiposity and Cardiovascular Disorders: Disturbance of the Regulatory System Consisting of Humoral and Neuronal Signals
Circ. Res., July 6, 2007; 101(1): 27 - 39.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. D. Knudson, G. M. Dick, and J. D. Tune
Adipokines and Coronary Vasomotor Dysfunction
Experimental Biology and Medicine, June 1, 2007; 232(6): 727 - 736.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. W. Franks, R. J. F. Loos, S. Brage, S. O'Rahilly, N. J. Wareham, and U. Ekelund
Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity
J Appl Physiol, May 1, 2007; 102(5): 1921 - 1926.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. G. Smith, P. A. Sheridan, J. B. Harp, and M. A. Beck
Diet-Induced Obese Mice Have Increased Mortality and Altered Immune Responses When Infected with Influenza Virus
J. Nutr., May 1, 2007; 137(5): 1236 - 1243.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bellmeyer, J. M. Martino, N. S. Chandel, G. R. Scott Budinger, D. A. Dean, and G. M. Mutlu
Leptin Resistance Protects Mice from Hyperoxia-induced Acute Lung Injury
Am. J. Respir. Crit. Care Med., March 15, 2007; 175(6): 587 - 594.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
D. Teta, M. Maillard, A. Tedjani, J. Passlick-Deetjen, and M. Burnier
The effect of pH-neutral peritoneal dialysis fluids on adipokine secretion from cultured adipocytes
Nephrol. Dial. Transplant., March 1, 2007; 22(3): 862 - 869.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. S. Desruisseaux, Nagajyothi, M. E. Trujillo, H. B. Tanowitz, and P. E. Scherer
Adipocyte, Adipose Tissue, and Infectious Disease
Infect. Immun., March 1, 2007; 75(3): 1066 - 1078.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Skurk, C. Alberti-Huber, C. Herder, and H. Hauner
Relationship between Adipocyte Size and Adipokine Expression and Secretion
J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 1023 - 1033.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. A. Shore
Obesity and asthma: lessons from animal models
J Appl Physiol, February 1, 2007; 102(2): 516 - 528.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. A. Johnston, T. A. Theman, R. D. Terry, E. S. Williams, and S. A. Shore
Pulmonary responses to acute ozone exposure in fasted mice: effect of leptin administration
J Appl Physiol, January 1, 2007; 102(1): 149 - 156.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. E. Pontiroli, P. Pizzocri, R. Paroni, and F. Folli
Sympathetic Overactivity, Endothelial Dysfunction, Inflammation, and Metabolic Abnormalities Cluster in Grade III (World Health Organization) Obesity: Reversal through sustained weight loss obtained with laparoscopic adjustable gastric banding
Diabetes Care, December 1, 2006; 29(12): 2735 - 2738.
[Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
N. Stefanou, M. Satra, V. Papanikolaou, F. Kalala, N. Gatselis, A. Germenis, G. N. Dalekos, and A. Tsezou
Leptin receptor isoforms mRNA expression in peripheral blood mononuclear cells from patients with chronic viral hepatitis.
Experimental Biology and Medicine, November 1, 2006; 231(10): 1653 - 1663.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Margalit, Z. Shalev, O. Pappo, M. Sklair-Levy, R. Alper, M. Gomori, D. Engelhardt, E. Rabbani, and Y. Ilan
Glucocerebroside Ameliorates the Metabolic Syndrome in OB/OB Mice
J. Pharmacol. Exp. Ther., October 1, 2006; 319(1): 105 - 110.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. W. Hick, A. L. Gruver, M. S. Ventevogel, B. F. Haynes, and G. D. Sempowski
Leptin Selectively Augments Thymopoiesis in Leptin Deficiency and Lipopolysaccharide-Induced Thymic Atrophy
J. Immunol., July 1, 2006; 177(1): 169 - 176.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Papathanassoglou, K. El-Haschimi, X. C. Li, G. Matarese, T. Strom, and C. Mantzoros
Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice.
J. Immunol., June 15, 2006; 176(12): 7745 - 7752.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
F. L. Lu, R. A. Johnston, L. Flynt, T. A. Theman, R. D. Terry, I. N. Schwartzman, A. Lee, and S. A. Shore
Increased pulmonary responses to acute ozone exposure in obese db/db mice
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L856 - L865.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Tedgui and Z. Mallat
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Physiol Rev, April 1, 2006; 86(2): 515 - 581.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. Plaisancie, R. Ducroc, M. E. Homsi, A. Tsocas, S. Guilmeau, S. Zoghbi, O. Thibaudeau, and A. Bado
Luminal leptin activates mucin-secreting goblet cells in the large bowel
Am J Physiol Gastrointest Liver Physiol, April 1, 2006; 290(4): G805 - G812.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A Sood, E S Ford, and C A Camargo Jr
Association between leptin and asthma in adults
Thorax, April 1, 2006; 61(4): 300 - 305.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Peters-Golden, A. Swern, S. S. Bird, C. M. Hustad, E. Grant, and J. M. Edelman
Influence of body mass index on the response to asthma controller agents.
Eur. Respir. J., March 1, 2006; 27(3): 495 - 503.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
M G Gnanalingham, A Mostyn, D S Gardner, T Stephenson, and M E Symonds
Developmental regulation of the lung in preparation for life after birth: hormonal and nutritional manipulation of local glucocorticoid action and uncoupling protein-2.
J. Endocrinol., March 1, 2006; 188(3): 375 - 386.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. A. Oral, E. D. Javor, L. Ding, G. Uzel, E. K. Cochran, J. R. Young, A. M. DePaoli, S. M. Holland, and P. Gorden
Leptin Replacement Therapy Modulates Circulating Lymphocyte Subsets and Cytokine Responsiveness in Severe Lipodystrophy
J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 621 - 628.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. G. Neels, M. Pandey, G. S. Hotamisligil, and F. Samad
Autoamplification of Tumor Necrosis Factor-{alpha}: A Potential Mechanism for the Maintenance of Elevated Tumor Necrosis Factor-{alpha} in Male but Not Female Obese Mice
Am. J. Pathol., February 1, 2006; 168(2): 435 - 444.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Varastehpour, T. Radaelli, J. Minium, H. Ortega, E. Herrera, P. Catalano, and S. Hauguel-de Mouzon
Activation of Phospholipase A2 Is Associated with Generation of Placental Lipid Signals and Fetal Obesity
J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 248 - 255.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C.-H. Lee, Y.-G. Chen, J. Chen, P. C. Reifsnyder, D. V. Serreze, M. Clare-Salzler, M. Rodriguez, C. Wasserfall, M. A. Atkinson, and E. H. Leiter
Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis
Diabetes, January 1, 2006; 55(1): 171 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. D. Knudson, U. D. Dincer, G. M. Dick, H. Shibata, R. Akahane, M. Saito, and J. D. Tune
Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction
Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1038 - H1046.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Lappas, M. Permezel, and G. E. Rice
Leptin and Adiponectin Stimulate the Release of Proinflammatory Cytokines and Prostaglandins from Human Placenta and Maternal Adipose Tissue via Nuclear Factor-{kappa}B, Peroxisomal Proliferator-Activated Receptor-{gamma} and Extracellularly Regulated Kinase 1/2
Endocrinology, August 1, 2005; 146(8): 3334 - 3342.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
C Popa, M G Netea, T R D S Radstake, P L van Riel, P Barrera, and J W M van der Meer
Markers of inflammation are negatively correlated with serum leptin in rheumatoid arthritis
Ann Rheum Dis, August 1, 2005; 64(8): 1195 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. D. Knudson, U. D. Dincer, C. Zhang, A. N. Swafford Jr., R. Koshida, A. Picchi, M. Focardi, G. M. Dick, and J. D. Tune
Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction
Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H48 - H56.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Bruno, S. Conus, I. Schmid, and H.-U. Simon
Apoptotic Pathways Are Inhibited by Leptin Receptor Activation in Neutrophils
J. Immunol., June 15, 2005; 174(12): 8090 - 8096.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Mattioli, E. Straface, M. G. Quaranta, L. Giordani, and M. Viora
Leptin Promotes Differentiation and Survival of Human Dendritic Cells and Licenses Them for Th1 Priming
J. Immunol., June 1, 2005; 174(11): 6820 - 6828.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. C. W. Lau, B. Dhillon, H. Yan, P. E. Szmitko, and S. Verma
Adipokines: molecular links between obesity and atheroslcerosis
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2031 - H2041.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
E. F. M. Wouters
Local and Systemic Inflammation in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, April 1, 2005; 2(1): 26 - 33.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. A. Tataranni and E. Ortega
A Burning Question: Does an Adipokine-Induced Activation of the Immune System Mediate the Effect of Overnutrition on Type 2 Diabetes?
Diabetes, April 1, 2005; 54(4): 917 - 927.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Matarese, S. Moschos, and C. S. Mantzoros
Leptin in Immunology
J. Immunol., March 15, 2005; 174(6): 3137 - 3142.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. G. Sulit, A. Storfer-Isser, C. L. Rosen, H. L. Kirchner, and S. Redline
Associations of Obesity, Sleep-disordered Breathing, and Wheezing in Children
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 659 - 664.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J. T Smith, P. J Mark, and B. J Waddell
Developmental increases in plasma leptin binding activity and tissue Ob-Re mRNA expression in the rat
J. Endocrinol., March 1, 2005; 184(3): 535 - 541.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. C. Patel, N. P. Nunez, S. N. Perkins, J. C. Barrett, and S. D. Hursting
Effects of Energy Balance on Cancer in Genetically Altered Mice
J. Nutr., December 1, 2004; 134(12): 3394S - 3398S.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Sachot, S. Poole, and G. N Luheshi
Circulating leptin mediates lipopolysaccharide-induced anorexia and fever in rats
J. Physiol., November 15, 2004; 561(1): 263 - 272.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
B. Siegmund, J. A. Sennello, H. A. Lehr, A. Batra, I. Fedke, M. Zeitz, and G. Fantuzzi
Development of intestinal inflammation in double IL-10- and leptin-deficient mice
J. Leukoc. Biol., October 1, 2004; 76(4): 782 - 786.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Peelman, K. Van Beneden, L. Zabeau, H. Iserentant, P. Ulrichts, D. Defeau, A. Verhee, D. Catteeuw, D. Elewaut, and J. Tavernier
Mapping of the Leptin Binding Sites and Design of a Leptin Antagonist
J. Biol. Chem., September 24, 2004; 279(39): 41038 - 41046.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
L. Ottonello, P. Gnerre, M. Bertolotto, M. Mancini, P. Dapino, R. Russo, G. Garibotto, T. Barreca, and F. Dallegri
Leptin as a Uremic Toxin Interferes with Neutrophil Chemotaxis
J. Am. Soc. Nephrol., September 1, 2004; 15(9): 2366 - 2372.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. D. Hursting, J. A. Lavigne, D. Berrigan, L. A. Donehower, B. J. Davis, J. M. Phang, J. C. Barrett, and S. N. Perkins
Diet-Gene Interactions in p53-Deficient Mice: Insulin-like Growth Factor-1 as a Mechanistic Target
J. Nutr., September 1, 2004; 134(9): 2482S - 2486S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. Mancuso, C. Canetti, A. Gottschalk, P. K. Tithof, and M. Peters-Golden
Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2{gamma}) protein expression
Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L497 - L502.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. M. H. van Dielen, W. A. Buurman, M. Hadfoune, J. Nijhuis, and J. W. Greve
Macrophage Inhibitory Factor, Plasminogen Activator Inhibitor-1, Other Acute Phase Proteins, and Inflammatory Mediators Normalize as a Result of Weight Loss in Morbidly Obese Subjects Treated with Gastric Restrictive Surgery
J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 4062 - 4068.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
J. Medina, L. I. Fernandez-Salazar, L. Garcia-Buey, and R. Moreno-Otero
Approach to the Pathogenesis and Treatment of Nonalcoholic Steatohepatitis
Diabetes Care, August 1, 2004; 27(8): 2057 - 2066.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. S.M. Shamsuzzaman, M. Winnicki, R. Wolk, A. Svatikova, B. G. Phillips, D. E. Davison, P. B. Berger, and V. K. Somers
Independent Association Between Plasma Leptin and C-Reactive Protein in Healthy Humans
Circulation, May 11, 2004; 109(18): 2181 - 2185.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. A. Curat, A. Miranville, C. Sengenes, M. Diehl, C. Tonus, R. Busse, and A. Bouloumie
From Blood Monocytes to Adipose Tissue-Resident Macrophages: Induction of Diapedesis by Human Mature Adipocytes
Diabetes, May 1, 2004; 53(5