| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The FASEB Journal, Vol 11, 308-313, Copyright © 1997 by The Federation of American Societies for Experimental Biology
REVIEWS |
JA Silverman and D Schrenk
AvMax, Inc., Berkeley, California 94710, USA.
The liver is presented with a diverse set of nutrients, endogenous metabolites, and xenobiotics it must process for movement to their correct physiologic destinations. These compounds are transported by specific mechanisms that move their substrates, often against a concentration gradient. Several hepatic transporters have been identified such as the multispecific anion transporter, cMOAT, bile acid transporters, ion-motive ATPases, glutathione transporters, purine transporters, and the multidrug resistance-related protein, MRP. This review focuses on the hepatic regulation of the multidrug resistance genes that encode the P-glycoprotein transporters. P-glycoproteins are ATP-dependent integral membrane proteins that have diverse functions such as conferring resistance toward chemotherapeutic drugs and phospholipid movement. The expression of the multidrug resistance genes is regulated in a tissue-specific pattern and can be induced by exposure to chemotherapeutic drugs as well as cytotoxic xenobiotics. The specific molecular mechanisms that govern expression of these genes in normal and neoplastic cells are currently being unraveled.
This article has been cited by other articles:
|
|
 |
|
  R. Callaghan, E. Crowley, S. Potter, and I. D. Kerr P-glycoprotein: So Many Ways to Turn It On J. Clin. Pharmacol., March 1, 2008; 48(3): 365 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Chang, C. J. Kochansky, and M. Shou The Role of P-glycoprotein in the Bioactivation of Raloxifene Drug Metab. Dispos., December 1, 2006; 34(12): 2073 - 2078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Annaert and K. L. R. Brouwer ASSESSMENT OF DRUG INTERACTIONS IN HEPATOBILIARY TRANSPORT USING RHODAMINE 123 IN SANDWICH-CULTURED RAT HEPATOCYTES Drug Metab. Dispos., March 1, 2005; 33(3): 388 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Albertus and R. Laine Enhanced xenobiotic transporter expression in normal teleost hepatocytes: response to environmental and chemotherapeutic toxins J. Exp. Biol., January 1, 2001; 204(2): 217 - 227. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Ogawa, H. Suzuki, T. Hirohashi, T. Ishikawa, P. J. Meier, K. Hirose, T. Akizawa, M. Yoshioka, and Y. Sugiyama Characterization of inducible nature of MRP3 in rat liver Am J Physiol Gastrointest Liver Physiol, March 1, 2000; 278(3): G438 - G446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Lin, M. Chiba, and T. A. Baillie Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized? Pharmacol. Rev., June 1, 1999; 51(2): 135 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ziemann, A. Burkle, G. F. Kahl, and K. I. Hirsch-Ernst Reactive oxygen species participate in mdr1b mRNA and P-glycoprotein overexpression in primary rat hepatocyte cultures Carcinogenesis, March 1, 1999; 20(3): 407 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Jackson, L. S. Birnbaum, and J. J. Diliberto Effects of Age, Sex, and Pharmacologic Agents on the Biliary Elimination of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in F344 Rats Drug Metab. Dispos., July 1, 1998; 26(7): 714 - 719. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
