The FASEB Journal, Vol 11, 271-275, Copyright © 1997 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Retinoic aid increases arrestin mRNA levels in the mouse retina

E Wagner, P McCaffery, J Mey, F Farhangfar, ML Applebury and UC Drager
E. Kennedy Shriver Center, Waltham, Massachusetts 02254, USA.

Arrestin, which plays a role in the termination of the visual transduction cascade, is one of several photoreceptor proteins whose mRNA levels are increased by light. Retinoic acid, a by-product of photoreceptor signaling and a potent modulator of hormonal transcription control, is one candidate for regulating the arrestin mRNA levels. Here we show that retinoic acid, injected intraperitoneally into dark-adapted mice, increases the arrestin mRNA levels and mimics the effect of light. Injection of 1 mumol of retinoic acid produces a maximal increase in arrestin mRNA levels. The mRNA level reaches a maximum 3 h after injection and slowly declines thereafter. The observations suggest that retinoic acid may mediate the increase in arrestin mRNA produced by light.

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