The FASEB Journal, Vol 11, 118-124, Copyright © 1997 by The Federation of American Societies for Experimental Biology

REVIEWS

An essential role for free radicals and derived species in signal transduction

HM Lander
Department of Biochemistry, Cornell University Medical College, New York 10021, USA.

It is well accepted that extracellular ligands trigger nuclear signals through a cascade of protein-protein interactions. Many of these pathways have been carefully defined and provide an important framework by which we can understand and intervene in the processes they initiate. Recent data in the literature indicate that many extracellular ligands generate and/or require reactive free radicals or derived species to successfully transmit their signals to the nucleus. Thus, a novel signaling mechanism akin to one solely dependent on protein-protein interactions may exist. Here, we review this information, identify both the sources and targets of free radicals generated by various growth factors and cytokines, discuss how specificity can be achieved, and explore the pathophysiological implications.

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				A. Gorlach, R. P. Brandes, K. Nguyen, M. Amidi, F. Dehghani, and R. Busse A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall Circ. Res., July 7, 2000; 87(1): 26 - 32. [Abstract] [Full Text] [PDF]

				C. G. Kevil, T. Oshima, B. Alexander, L. L. Coe, and J. S. Alexander H2O2-mediated permeability: role of MAPK and occludin Am J Physiol Cell Physiol, July 1, 2000; 279(1): C21 - C30. [Abstract] [Full Text] [PDF]

				J. Ruef, S.-Q. Liu, C. Bode, M. Tocchi, S. Srivastava, M. S. Runge, and A. Bhatnagar Involvement of Aldose Reductase in Vascular Smooth Muscle Cell Growth and Lesion Formation After Arterial Injury Arterioscler Thromb Vasc Biol, July 1, 2000; 20(7): 1745 - 1752. [Abstract] [Full Text] [PDF]

				M.-C. Broillet A Single Intracellular Cysteine Residue Is Responsible for the Activation of the Olfactory Cyclic Nucleotide-gated Channel by NO J. Biol. Chem., May 12, 2000; 275(20): 15135 - 15141. [Abstract] [Full Text] [PDF]

				L. Cominacini, A. F. Pasini, U. Garbin, A. Davoli, M. L. Tosetti, M. Campagnola, A. Rigoni, A. M. Pastorino, V. Lo Cascio, and T. Sawamura Oxidized Low Density Lipoprotein (ox-LDL) Binding to ox-LDL Receptor-1 in Endothelial Cells Induces the Activation of NF-kappa B through an Increased Production of Intracellular Reactive Oxygen Species J. Biol. Chem., April 21, 2000; 275(17): 12633 - 12638. [Abstract] [Full Text] [PDF]

				M. Stanciu, Y. Wang, R. Kentor, N. Burke, S. Watkins, G. Kress, I. Reynolds, E. Klann, M. R. Angiolieri, J. W. Johnson, et al. Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures J. Biol. Chem., April 14, 2000; 275(16): 12200 - 12206. [Abstract] [Full Text] [PDF]

				D. Bellincampi, N. Dipierro, G. Salvi, F. Cervone, and G. De Lorenzo Extracellular H2O2 Induced by Oligogalacturonides Is Not Involved in the Inhibition of the Auxin-Regulated rolB Gene Expression in Tobacco Leaf Explants Plant Physiology, April 1, 2000; 122(4): 1379 - 1386. [Abstract] [Full Text]

				K. Takeyama, K. Dabbagh, J. Jeong Shim, T. Dao-Pick, I. F. Ueki, and J. A. Nadel Oxidative Stress Causes Mucin Synthesis Via Transactivation of Epidermal Growth Factor Receptor: Role of Neutrophils J. Immunol., February 1, 2000; 164(3): 1546 - 1552. [Abstract] [Full Text] [PDF]

				E Maellaro, S Dominici, B Del Bello, M. Valentini, L Pieri, P Perego, R Supino, F Zunino, E Lorenzini, A Paolicchi, et al. Membrane gamma-glutamyl transpeptidase activity of melanoma cells: effects on cellular H(2)O(2) production, cell surface protein thiol oxidation and NF-kappa B activation status J. Cell Sci., January 8, 2000; 113(15): 2671 - 2678. [Abstract] [PDF]

				M. A. Cunningham, P. Romas, P. Hutchinson, S. R. Holdsworth, and P. G. Tipping Tissue Factor and Factor VIIa Receptor/Ligand Interactions Induce Proinflammatory Effects in Macrophages Blood, November 15, 1999; 94(10): 3413 - 3420. [Abstract] [Full Text] [PDF]

				A. Ishida, T. Sasaguri, Y. Miwa, C. Kosaka, Y. Taba, and T. Abumiya Tumor Suppressor p53 But Not cGMP Mediates NO-Induced Expression of p21Waf1/Cip1/Sdi1 in Vascular Smooth Muscle Cells Mol. Pharmacol., November 1, 1999; 56(5): 938 - 946. [Abstract] [Full Text]

				Z. Wei, K. Costa, A. B. Al-Mehdi, C. Dodia, V. Muzykantov, and A. B. Fisher Simulated Ischemia in Flow-Adapted Endothelial Cells Leads to Generation of Reactive Oxygen Species and Cell Signaling Circ. Res., October 15, 1999; 85(8): 682 - 689. [Abstract] [Full Text] [PDF]

				M. Usui, K. Egashira, S. Kitamoto, M. Koyanagi, M. Katoh, C. Kataoka, H. Shimokawa, and A. Takeshita Pathogenic Role of Oxidative Stress in Vascular Angiotensin-Converting Enzyme Activation in Long-Term Blockade of Nitric Oxide Synthesis in Rats Hypertension, October 1, 1999; 34(4): 546 - 551. [Abstract] [Full Text] [PDF]

				A. von Knethen, D. Callsen, and B. Brune Superoxide Attenuates Macrophage Apoptosis by NF-{kappa}B and AP-1 Activation That Promotes Cyclooxygenase-2 Expression J. Immunol., September 1, 1999; 163(5): 2858 - 2866. [Abstract] [Full Text] [PDF]

				B. Zech, M. Wilm, R. van Eldik, and B. Brune Mass Spectrometric Analysis of Nitric Oxide-modified Caspase-3 J. Biol. Chem., July 23, 1999; 274(30): 20931 - 20936. [Abstract] [Full Text] [PDF]

				S. Glockzin, A. von Knethen, M. Scheffner, and B. Brune Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome J. Biol. Chem., July 9, 1999; 274(28): 19581 - 19586. [Abstract] [Full Text] [PDF]