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The FASEB Journal, Vol 11, 118-124, Copyright © 1997 by The Federation of American Societies for Experimental Biology


REVIEWS

An essential role for free radicals and derived species in signal transduction

HM Lander
Department of Biochemistry, Cornell University Medical College, New York 10021, USA.

It is well accepted that extracellular ligands trigger nuclear signals through a cascade of protein-protein interactions. Many of these pathways have been carefully defined and provide an important framework by which we can understand and intervene in the processes they initiate. Recent data in the literature indicate that many extracellular ligands generate and/or require reactive free radicals or derived species to successfully transmit their signals to the nucleus. Thus, a novel signaling mechanism akin to one solely dependent on protein-protein interactions may exist. Here, we review this information, identify both the sources and targets of free radicals generated by various growth factors and cytokines, discuss how specificity can be achieved, and explore the pathophysiological implications.


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Home page
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Home page
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Home page
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Home page
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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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F. Esposito, G. Chirico, N. M. Gesualdi, I. Posadas, R. Ammendola, T. Russo, G. Cirino, and F. Cimino
Protein Kinase B Activation by Reactive Oxygen Species Is Independent of Tyrosine Kinase Receptor Phosphorylation and Requires Src Activity
J. Biol. Chem., May 30, 2003; 278(23): 20828 - 20834.
[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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Increased Nox2 expression in human cardiomyocytes after acute myocardial infarction
J. Clin. Pathol., March 1, 2003; 56(3): 194 - 199.
[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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Home page
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Home page
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Home page
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Home page
J. Immunol.Home page
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[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
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Home page
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Home page
J. Biol. Chem.Home page
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J. Biol. Chem., June 21, 2002; 277(26): 23949 - 23957.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
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J. Biol. Chem., May 24, 2002; 277(22): 19585 - 19593.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
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Home page
J. Immunol.Home page
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J. Immunol., March 1, 2002; 168(5): 2560 - 2567.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
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Mol. Pharmacol., February 1, 2002; 61(2): 260 - 268.
[Abstract] [Full Text] [PDF]


Home page
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J. Exp. Med., January 7, 2002; 195(1): 59 - 70.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
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Free Radicals in the Physiological Control of Cell Function
Physiol Rev, January 1, 2002; 82(1): 47 - 95.
[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
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Home page
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Home page
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Home page
Eur Respir JHome page
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Home page
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Home page
Exp. Biol. Med.Home page
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Home page
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Home page
Circ. Res.Home page
C. Patterson, G. A. Stouffer, N. Madamanchi, and M. S. Runge
New Tricks for Old Dogs : Nonthrombotic Effects of Thrombin in Vessel Wall Biology
Circ. Res., May 25, 2001; 88(10): 987 - 997.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
S. R. Thomas, H. Salahifar, R. Mashima, N. H. Hunt, D. R. Richardson, and R. Stocker
Antioxidants Inhibit Indoleamine 2,3-Dioxygenase in IFN-{{gamma}}-Activated Human Macrophages: Posttranslational Regulation by Pyrrolidine Dithiocarbamate
J. Immunol., May 15, 2001; 166(10): 6332 - 6340.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Cell Physiol.Home page
H. Lum and K. A. Roebuck
Oxidant stress and endothelial cell dysfunction
Am J Physiol Cell Physiol, April 1, 2001; 280(4): C719 - C741.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Ischiropoulos
Reactive species and signal transduction
Am J Physiol Lung Cell Mol Physiol, April 1, 2001; 280(4): L583 - L584.
[Full Text] [PDF]


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Cancer Res.Home page
A. Kamsler, D. Daily, A. Hochman, N. Stern, Y. Shiloh, G. Rotman, and A. Barzilai
Increased Oxidative Stress in Ataxia Telangiectasia Evidenced by Alterations in Redox State of Brains from Atm-deficient Mice
Cancer Res., March 1, 2001; 61(5): 1849 - 1854.
[Abstract] [Full Text]


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Cancer Res.Home page
R. Koren, I. Hadari-Naor, E. Zuck, C. Rotem, U. A. Liberman, and A. Ravid
Vitamin D Is a Prooxidant in Breast Cancer Cells
Cancer Res., February 1, 2001; 61(4): 1439 - 1444.
[Abstract] [Full Text]


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Am. J. Respir. Cell Mol. Bio.Home page
J. Girón-Calle and H. J. Forman
Phospholipase D and Priming of the Respiratory Burst by H2O2 in NR8383 Alveolar Macrophages
Am. J. Respir. Cell Mol. Biol., December 1, 2000; 23(6): 748 - 754.
[Abstract] [Full Text]


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J. Neurosci.Home page
E. Thiels, N. N. Urban, G. R. Gonzalez-Burgos, B. I. Kanterewicz, G. Barrionuevo, C. T. Chu, T. D. Oury, and E. Klann
Impairment of Long-term Potentiation and Associative Memory in Mice That Overexpress Extracellular Superoxide Dismutase
J. Neurosci., October 15, 2000; 20(20): 7631 - 7639.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
S. P. Hehner, R. Breitkreutz, G. Shubinsky, H. Unsoeld, K. Schulze-Osthoff, M. L. Schmitz, and W. Droge
Enhancement of T Cell Receptor Signaling by a Mild Oxidative Shift in the Intracellular Thiol Pool
J. Immunol., October 15, 2000; 165(8): 4319 - 4328.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
S. Nemoto, K. Takeda, Z.-X. Yu, V. J. Ferrans, and T. Finkel
Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism
Mol. Cell. Biol., October 1, 2000; 20(19): 7311 - 7318.
[Abstract] [Full Text]


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FASEB J.Home page
V. J. THANNICKAL, R. M. DAY, S. G. KLINZ, M. C. BASTIEN, J. M. LARIOS, and B. L. FANBURG
Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-{beta}1
FASEB J, September 1, 2000; 14(12): 1741 - 1748.
[Abstract] [Full Text]


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Nephrol Dial TransplantHome page
W. Gwinner and H.-J. Grone
Role of reactive oxygen species in glomerulonephritis
Nephrol. Dial. Transplant., August 1, 2000; 15(8): 1127 - 1132.
[Full Text] [PDF]


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FASEB J.Home page
A. GÖRLACH, R. P. BRANDES, S. BASSUS, N. KRONEMANN, C. M. KIRCHMAIER, R. BUSSE, and V. B. SCHINI-KERTH
Oxidative stress and expression of p22phox are involved in the up-regulation of tissue factor in vascular smooth muscle cells in response to activated platelets
FASEB J, August 1, 2000; 14(11): 1518 - 1528.
[Abstract] [Full Text]


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Am. J. Physiol. Heart Circ. Physiol.Home page
S. Meloche, J. Landry, J. Huot, F. Houle, F. Marceau, and E. Giasson
p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle
Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H741 - H751.
[Abstract] [Full Text] [PDF]


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Circ. Res.Home page
A. Gorlach, R. P. Brandes, K. Nguyen, M. Amidi, F. Dehghani, and R. Busse
A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall
Circ. Res., July 7, 2000; 87(1): 26 - 32.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Cell Physiol.Home page
C. G. Kevil, T. Oshima, B. Alexander, L. L. Coe, and J. S. Alexander
H2O2-mediated permeability: role of MAPK and occludin
Am J Physiol Cell Physiol, July 1, 2000; 279(1): C21 - C30.
[Abstract] [Full Text] [PDF]


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Arterioscler. Thromb. Vasc. Bio.Home page
J. Ruef, S.-Q. Liu, C. Bode, M. Tocchi, S. Srivastava, M. S. Runge, and A. Bhatnagar
Involvement of Aldose Reductase in Vascular Smooth Muscle Cell Growth and Lesion Formation After Arterial Injury
Arterioscler Thromb Vasc Biol, July 1, 2000; 20(7): 1745 - 1752.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
M.-C. Broillet
A Single Intracellular Cysteine Residue Is Responsible for the Activation of the Olfactory Cyclic Nucleotide-gated Channel by NO
J. Biol. Chem., May 12, 2000; 275(20): 15135 - 15141.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
L. Cominacini, A. F. Pasini, U. Garbin, A. Davoli, M. L. Tosetti, M. Campagnola, A. Rigoni, A. M. Pastorino, V. Lo Cascio, and T. Sawamura
Oxidized Low Density Lipoprotein (ox-LDL) Binding to ox-LDL Receptor-1 in Endothelial Cells Induces the Activation of NF-kappa B through an Increased Production of Intracellular Reactive Oxygen Species
J. Biol. Chem., April 21, 2000; 275(17): 12633 - 12638.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
M. Stanciu, Y. Wang, R. Kentor, N. Burke, S. Watkins, G. Kress, I. Reynolds, E. Klann, M. R. Angiolieri, J. W. Johnson, et al.
Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures
J. Biol. Chem., April 14, 2000; 275(16): 12200 - 12206.
[Abstract] [Full Text] [PDF]


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Plant Physiol.Home page
D. Bellincampi, N. Dipierro, G. Salvi, F. Cervone, and G. De Lorenzo
Extracellular H2O2 Induced by Oligogalacturonides Is Not Involved in the Inhibition of the Auxin-Regulated rolB Gene Expression in Tobacco Leaf Explants
Plant Physiology, April 1, 2000; 122(4): 1379 - 1386.
[Abstract] [Full Text]


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J. Immunol.Home page
K. Takeyama, K. Dabbagh, J. Jeong Shim, T. Dao-Pick, I. F. Ueki, and J. A. Nadel
Oxidative Stress Causes Mucin Synthesis Via Transactivation of Epidermal Growth Factor Receptor: Role of Neutrophils
J. Immunol., February 1, 2000; 164(3): 1546 - 1552.
[Abstract] [Full Text] [PDF]


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J. Cell Sci.Home page
E Maellaro, S Dominici, B Del Bello, M. Valentini, L Pieri, P Perego, R Supino, F Zunino, E Lorenzini, A Paolicchi, et al.
Membrane gamma-glutamyl transpeptidase activity of melanoma cells: effects on cellular H(2)O(2) production, cell surface protein thiol oxidation and NF-kappa B activation status
J. Cell Sci., January 8, 2000; 113(15): 2671 - 2678.
[Abstract] [PDF]


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BloodHome page
M. A. Cunningham, P. Romas, P. Hutchinson, S. R. Holdsworth, and P. G. Tipping
Tissue Factor and Factor VIIa Receptor/Ligand Interactions Induce Proinflammatory Effects in Macrophages
Blood, November 15, 1999; 94(10): 3413 - 3420.
[Abstract] [Full Text] [PDF]


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Mol. Pharmacol.Home page
A. Ishida, T. Sasaguri, Y. Miwa, C. Kosaka, Y. Taba, and T. Abumiya
Tumor Suppressor p53 But Not cGMP Mediates NO-Induced Expression of p21Waf1/Cip1/Sdi1 in Vascular Smooth Muscle Cells
Mol. Pharmacol., November 1, 1999; 56(5): 938 - 946.
[Abstract] [Full Text]


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Circ. Res.Home page
Z. Wei, K. Costa, A. B. Al-Mehdi, C. Dodia, V. Muzykantov, and A. B. Fisher
Simulated Ischemia in Flow-Adapted Endothelial Cells Leads to Generation of Reactive Oxygen Species and Cell Signaling
Circ. Res., October 15, 1999; 85(8): 682 - 689.
[Abstract] [Full Text] [PDF]


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HypertensionHome page
M. Usui, K. Egashira, S. Kitamoto, M. Koyanagi, M. Katoh, C. Kataoka, H. Shimokawa, and A. Takeshita
Pathogenic Role of Oxidative Stress in Vascular Angiotensin-Converting Enzyme Activation in Long-Term Blockade of Nitric Oxide Synthesis in Rats
Hypertension, October 1, 1999; 34(4): 546 - 551.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
A. von Knethen, D. Callsen, and B. Brune
Superoxide Attenuates Macrophage Apoptosis by NF-{kappa}B and AP-1 Activation That Promotes Cyclooxygenase-2 Expression
J. Immunol., September 1, 1999; 163(5): 2858 - 2866.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
B. Zech, M. Wilm, R. van Eldik, and B. Brune
Mass Spectrometric Analysis of Nitric Oxide-modified Caspase-3
J. Biol. Chem., July 23, 1999; 274(30): 20931 - 20936.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
S. Glockzin, A. von Knethen, M. Scheffner, and B. Brune
Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome
J. Biol. Chem., July 9, 1999; 274(28): 19581 - 19586.
[Abstract] [Full Text] [PDF]




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