| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The FASEB Journal, Vol 11, 765-774, Copyright © 1997 by The Federation of American Societies for Experimental Biology
RESEARCH COMMUNICATIONS |
AA Maghazachi, BS Skalhegg, B Rolstad and A Al-Aoukaty
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway.
We show here that interferon-inducible protein-10 (IP-10), an ELR lacking CXC chemokine, and the C chemokine lymphotactin (Ltn) induce the chemotaxis and calcium mobilization in IL2-activated NK (IANK) and CC chemokine-activated NK (CHAK) cells. Cross-desensitization experiments show that IP-10 or Ltn use receptors not shared by other C, CC, or CXC chemokines. The chemotaxis induced by either IP-10 or Ltn for both cell types is inhibited upon pretreatment of these cells with pertussis toxin (PT). Also, Ltn-induced [Ca2+]i in IANK but not in CHAK cells is inhibited upon pretreatment with PT, whereas IP-10-induced [Ca2+]i in IANK and CHAK cells is inhibited upon pretreatment with this toxin. These results suggest important roles for PT-sensitive and - insensitive G-proteins in IP-10-induced and Ltn-induced chemotaxis and calcium fluxes in activated NK cells. This was further implicated after streptolysin O permeabilization of CHAK and IANK cells and after introduction of inhibitory antibodies to the PT-sensitive Gi and Go or the PT-insensitive Gq. Our results suggest that IP-10 and Ltn receptors are coupled to Gi, Go, and Gq in IANK cells and to Gi and Gq in CHAK cells, with a possible low coupling of IP-10, but not of Ltn, receptors to Go in these cells. Together, these results show that IP-10 and Ltn- dependent chemotaxis and calcium mobilization may differentiate at the level of receptor coupling to the heterotrimeric G-proteins.
This article has been cited by other articles:
|
|
 |
|
  G. Shi, S. Partida-Sanchez, R. S. Misra, M. Tighe, M. T. Borchers, J. J. Lee, M. I. Simon, and F. E. Lund Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes J. Exp. Med., October 29, 2007; 204(11): 2705 - 2718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. R. Luttichau, A. H. Johnsen, J. Jurlander, M. M. Rosenkilde, and T. W. Schwartz Kaposi Sarcoma-associated Herpes Virus Targets the Lymphotactin Receptor with Both a Broad Spectrum Antagonist vCCL2 and a Highly Selective and Potent Agonist vCCL3 J. Biol. Chem., June 15, 2007; 282(24): 17794 - 17805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Maghazachi Insights into Seven and Single Transmembrane-Spanning Domain Receptors and Their Signaling Pathways in Human Natural Killer Cells Pharmacol. Rev., September 1, 2005; 57(3): 339 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-J. Li, M. Yao, M. Dueck, J. E. Feugate, V. Parpura, and M. Martins-Green cCXCR1 is a receptor for cIL-8 (9E3/cCAF) and its N- and C-terminal peptides and is also activated by hIL-8 (CXCL8) J. Leukoc. Biol., March 1, 2005; 77(3): 421 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Trifilo, C. Montalto-Morrison, L. N. Stiles, K. R. Hurst, J. L. Hardison, J. E. Manning, P. S. Masters, and T. E. Lane CXC Chemokine Ligand 10 Controls Viral Infection in the Central Nervous System: Evidence for a Role in Innate Immune Response through Recruitment and Activation of Natural Killer Cells J. Virol., January 15, 2004; 78(2): 585 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Inngjerdingen, B. Rolstad, and J. C. Ryan Activating and Inhibitory Ly49 Receptors Modulate NK Cell Chemotaxis to CXC Chemokine Ligand (CXCL) 10 and CXCL12 J. Immunol., September 15, 2003; 171(6): 2889 - 2895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Maghazachi G protein-coupled receptors in natural killer cells J. Leukoc. Biol., July 1, 2003; 74(1): 16 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lasagni, M. Francalanci, F. Annunziato, E. Lazzeri, S. Giannini, L. Cosmi, C. Sagrinati, B. Mazzinghi, C. Orlando, E. Maggi, et al. An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4 J. Exp. Med., June 2, 2003; 197(11): 1537 - 1549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Marti, E. Bertran, M. Llucia, E. Villen, M. Peiro, J. Garcia, and F. Rueda Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8 J. Leukoc. Biol., September 1, 2002; 72(3): 590 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Robertson Role of chemokines in the biology of natural killer cells J. Leukoc. Biol., February 1, 2002; 71(2): 173 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mene, F. Festuccia, R. Polci, F. Pugliese, and G. A. Cinotti Transmembrane signalling in human monocyte/mesangial cell co-cultures: role of cytosolic Ca2+ Nephrol. Dial. Transplant., January 1, 2002; 17(1): 42 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawakami, Y. Kinjo, K. Uezu, S. Yara, K. Miyagi, Y. Koguchi, T. Nakayama, M. Taniguchi, and A. Saito Monocyte Chemoattractant Protein-1-Dependent Increase of V{alpha}14 NKT Cells in Lungs and Their Roles in Th1 Response and Host Defense in Cryptococcal Infection J. Immunol., December 1, 2001; 167(11): 6525 - 6532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Middel, P. Thelen, S. Blaschke, F. Polzien, K. Reich, V. Blaschke, A. Wrede, K. M. Hummel, B. Gunawan, and H.-J. Radzun Expression of the T-Cell Chemoattractant Chemokine Lymphotactin in Crohn's Disease Am. J. Pathol., November 1, 2001; 159(5): 1751 - 1761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cerdan, E. Devilard, L. Xerri, and D. Olive The C-class chemokine lymphotactin costimulates the apoptosis of human CD4+ T cells Blood, April 15, 2001; 97(8): 2205 - 2212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Qiu, K. A. Frait, F. Reich, E. Komuniecki, and S. W. Chensue Chemokine Expression Dynamics in Mycobacterial (Type-1) and Schistosomal (Type-2) Antigen-Elicited Pulmonary Granuloma Formation Am. J. Pathol., April 1, 2001; 158(4): 1503 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Romagnani, F. Annunziato, E. Lazzeri, L. Cosmi, C. Beltrame, L. Lasagni, G. Galli, M. Francalanci, R. Manetti, F. Marra, et al. Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) {alpha}{beta}+CD8+ single-positive T cells, TCR{gamma}{delta}+ T cells, and natural killer-type cells in human thymus Blood, February 1, 2001; 97(3): 601 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inngjerdingen, B. Damaj, and A. A. Maghazachi Expression and regulation of chemokine receptors in human natural killer cells Blood, January 15, 2001; 97(2): 367 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cerdan, E. Serfling, and D. Olive The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4+ T cells Blood, July 15, 2000; 96(2): 420 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inngjerdingen, B. Damaj, and A. A. Maghazachi Human NK Cells Express CC Chemokine Receptors 4 and 8 and Respond to Thymus and Activation-Regulated Chemokine, Macrophage-Derived Chemokine, and I-309 J. Immunol., April 15, 2000; 164(8): 4048 - 4054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sasayama, M. Okada, and A. Matsumori Chemokines and cardiovascular diseases Cardiovasc Res, January 14, 2000; 45(2): 267 - 269. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Vester, K. Muller, W. Solbach, and T. Laskay Early Gene Expression of NK Cell-Activating Chemokines in Mice Resistant to Leishmania major Infect. Immun., June 1, 1999; 67(6): 3155 - 3159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Al-Aoukaty, B. Rolstad, and A. A. Maghazachi Recruitment of Pleckstrin and Phosphoinositide 3-Kinase {gamma} into the Cell Membranes, and Their Association with G{beta}{gamma} After Activation of NK Cells with Chemokines J. Immunol., March 15, 1999; 162(6): 3249 - 3255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mahalingam, J. M. Farber, and G. Karupiah The Interferon-Inducible Chemokines MuMig and Crg-2 Exhibit Antiviral Activity In Vivo J. Virol., February 1, 1999; 73(2): 1479 - 1491. [Abstract] [Full Text]
|
|
|
|
|
|
E. Geras-Raaka, A. Varma, H. Ho, I. Clark-Lewis, and M. C. Gershengorn Human Interferon-gamma -inducible Protein 10 (IP-10) Inhibits Constitutive Signaling of Kaposi's Sarcoma-associated Herpesvirus G Protein-coupled Receptor J. Exp. Med., July 20, 1998; 188(2): 405 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yoshida, T. Imai, M. Kakizaki, M. Nishimura, S. Takagi, and O. Yoshie Identification of Single C Motif-1/Lymphotactin Receptor XCR1 J. Biol. Chem., June 26, 1998; 273(26): 16551 - 16554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Gangur, F. E. R. Simons, and K. T. Hayglass Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-{gamma} over IL-4 responses FASEB J, June 1, 1998; 12(9): 705 - 713. [Abstract] [Full Text]
|
|
|
|
|
|
A. Al-Aoukaty, B. Rolstad, and A. A. Maghazachi Functional Coupling of NKR-P1 Receptors to Various Heterotrimeric G Proteins in Rat Interleukin-2-activated Natural Killer Cells J. Biol. Chem., December 12, 1997; 272(50): 31604 - 31608. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
